scholarly journals Multi-omics analysis based on integrated genomics, epigenomics and transcriptomics in pancreatic cancer

Epigenomics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 507-524 ◽  
Author(s):  
Lingming Kong ◽  
Peng Liu ◽  
Mingjun Zheng ◽  
Busheng Xue ◽  
Keke Liang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Copy Number Variation ◽  
Copy Number ◽  
Integrated Analysis ◽  
Molecular Subgroups ◽  
Dna Copy Number ◽  
Dna Copy Number Variation ◽  
New Genes ◽  
Omics Analysis ◽  
Number Variation

Aim: Integrated analysis of genomics, epigenomics, transcriptomics and clinical information contributes to identify specific molecular subgroups and find novel biomarkers for pancreatic cancer. Materials & methods: The DNA copy number variation, the simple nucleotide variation, methylation and mRNA data of pancreatic cancer patients were obtained from The Cancer Genome Atlas. Four molecular subgroups (iC1, iC2, iC3 and iC4) of pancreatic cancer were identified by integrating analysis. Results: The iC1 subgroup harbors better prognosis, higher immune score, lesser DNA copy number variation mutations and better genomic stability compared with iC2, iC3 and iC4 subgroups. Three new genes ( GRAP2, ICAM3 and A2ML1) correlated with prognosis were identified. Conclusion: Integrated multi-omics analysis provides fresh insight into molecular classification of pancreatic cancer, which may help discover new prognostic biomarkers and reveal the underlying mechanism of pancreatic cancer.

DNA copy number variation screening in familial hypercholesterolemia-related genes

2018 ◽  
Vol 275 ◽  
pp. e79
Author(s):  
M. Iacocca ◽  
J. Wang ◽  
J. Dron ◽  
H. Cao ◽  
J. Robinson ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Familial Hypercholesterolemia ◽  
Copy Number ◽  
Dna Copy Number ◽  
Dna Copy Number Variation ◽  
Number Variation

DNA Copy Number Variation and Gene Expression Analyses Reveal the Implication of Specific Oncogenes and Genes in GBM

2009 ◽  
Vol 27 (5) ◽  
pp. 541-548 ◽  
Author(s):  
Javier Margareto ◽  
Olatz Leis ◽  
Eider Larrarte ◽  
Iñigo C. Pomposo ◽  
Jesús María Garibi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copy Number Variation ◽  
Copy Number ◽  
Dna Copy Number ◽  
Dna Copy Number Variation ◽  
Gene Expression Analyses ◽  
Number Variation

scholarly journals Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer

2016 ◽  
Vol 186 (8) ◽  
pp. 2055-2067 ◽  
Author(s):  
Kazunori Kawaguchi ◽  
Masao Honda ◽  
Taro Yamashita ◽  
Hikari Okada ◽  
Takayoshi Shirasaki ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Copy Number Variation ◽  
Copy Number ◽  
Dna Copy Number ◽  
Dna Copy Number Variation ◽  
Poor Outcome ◽  
Number Variation

Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays

10.1038/14385 ◽  
1999 ◽  
Vol 23 (S3) ◽  
pp. 69-69 ◽  
Author(s):  
Jonathan R. Pollack ◽  
Charles M. Perou ◽  
Therese Sorlie ◽  
Ash A. Alizadeh ◽  
Christian Rees ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Copy Number Variation ◽  
Copy Number ◽  
Dna Microarrays ◽  
Dna Copy Number ◽  
Genome Wide Analysis ◽  
Dna Copy Number Variation ◽  
Genome Wide ◽  
Number Variation
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