Ask the Experts: What do we know (and not know) about prescription opioid misuse in the context of chronic pain management?

2011 ◽  
Vol 1 (5) ◽  
pp. 395-398
Author(s):  
James Zacny
Keyword(s):  
Chronic Pain ◽  
Pain Management ◽  
Prescription Opioid ◽  
Chronic Pain Management ◽  
Opioid Misuse ◽  
Prescription Opioid Misuse

scholarly journals Social Media as an Emerging Tool for Reducing Prescription Opioid Misuse Risk Factors (Preprint)

2018 ◽  
Author(s):  
Sean Young ◽  
Sung-Jae Lee ◽  
Hendry Perez ◽  
Navkiran Gill ◽  
Lillian Gelberg ◽  
...  
Keyword(s):  
Social Media ◽  
Chronic Pain ◽  
Online Community ◽  
Prescription Opioid ◽  
Control Group ◽  
Opioid Misuse ◽  
Opioid Use ◽  
Online Behavior ◽  
Prescription Opioid Misuse

BACKGROUND Interventions are urgently needed to reduce prescription opioid misuse risk factors, including anxiety and concomitant use of sedatives. However, only 5 randomized controlled opioid intervention trials have been conducted, with none showing improvements in anxiety. OBJECTIVE We sought to determine the feasibility of using an online behavior change community, compared to a control Facebook group, to reduce anxiety and opioid misuse among chronic pain patients. METHODS 51 high-risk non-cancer chronic pain patients were randomly assigned to either a Harnessing Online Peer Education (HOPE) peer-led online behavior change intervention or a control group (no peer leaders) on Facebook for 12 weeks. Inclusion criteria were: 18 years or older, a UCLA Health System patient, prescribed an opioid for non-cancer chronic pain between 3 and 12 months ago, and a score of ≥ 9 on the Current Opioid Misuse Measure (COMM) and/or concomitant use of benzodiazepines. Participation in the online community was voluntary. Patients completed baseline and follow-up assessments on Generalized Anxiety Disorder screener (GAD-7), COMM, and frequency of social media discussions about pain and opioid use. RESULTS Compared to control group participants, intervention participants showed a baseline-to-follow-up decrease in anxiety, and more frequently used social media to discuss pain, prescription opioid use, coping strategies, places to seek help, and alternative therapies for pain. Both groups showed a baseline to follow-up decrease in COMM score. CONCLUSIONS Results support the feasibility of using an online community interventions as a low-cost tool to decrease risk for prescription opioid misuse and its complications. CLINICALTRIAL ClinicalTrials.gov: NCT02735785

scholarly journals The Association Between Negative Affect and Prescription Opioid Misuse in Patients With Chronic Pain: The Mediating Role of Opioid Craving

2014 ◽  
Vol 15 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Marc O. Martel ◽  
Andrew J. Dolman ◽  
Robert R. Edwards ◽  
Robert N. Jamison ◽  
Ajay D. Wasan
Keyword(s):  
Chronic Pain ◽  
Negative Affect ◽  
Prescription Opioid ◽  
Opioid Misuse ◽  
Mediating Role ◽  
Prescription Opioid Misuse

scholarly journals Distress Intolerance and Prescription Opioid Misuse Among Patients With Chronic Pain

2016 ◽  
Vol 17 (7) ◽  
pp. 806-814 ◽  
Author(s):  
R. Kathryn McHugh ◽  
Roger D. Weiss ◽  
Marise Cornelius ◽  
Marc O. Martel ◽  
Robert N. Jamison ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Prescription Opioid ◽  
Opioid Misuse ◽  
Distress Intolerance ◽  
Prescription Opioid Misuse

Training internal medicine residents to manage chronic pain and prescription opioid misuse

2017 ◽  
Vol 38 (2) ◽  
pp. 200-204 ◽  
Author(s):  
Allison L. Ruff ◽  
Daniel P. Alford ◽  
Robert Butler ◽  
J. Henry Isaacson
Keyword(s):  
Internal Medicine ◽  
Chronic Pain ◽  
Prescription Opioid ◽  
Opioid Misuse ◽  
Internal Medicine Residents ◽  
Prescription Opioid Misuse

scholarly journals The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways

2013 ◽  
Vol 37 (10) ◽  
pp. 2597-2607 ◽  
Author(s):  
Eric L. Garland ◽  
Brett Froeliger ◽  
Fadel Zeidan ◽  
Kaitlyn Partin ◽  
Matthew O. Howard
Keyword(s):  
Chronic Pain ◽  
Prescription Opioid ◽  
Opioid Misuse ◽  
Downward Spiral ◽  
Prescription Opioid Misuse

scholarly journals Establishing the content validity of the Prescription Opioid Misuse and Abuse Questionnaire (POMAQ) among chronic pain patients

2020 ◽  
pp. 1-1
Author(s):  
Karin S. Coyne ◽  
Alexandra I. Barsdorf ◽  
Anne Brooks ◽  
Jean-Yves Mazèire ◽  
Renee F. Pierson ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Content Validity ◽  
Prescription Opioid ◽  
Opioid Misuse ◽  
Chronic Pain Patients ◽  
Prescription Opioid Misuse ◽  
Pain Patients

scholarly journals Epigenetic Alterations in Prescription Opioid Misuse: New Strategies for Precision Pain Management

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1226
Author(s):  
Maria Carla Gerra ◽  
Cristina Dallabona ◽  
Lars Arendt-Nielsen
Keyword(s):  
Chronic Pain ◽  
Pain Management ◽  
Human Subjects ◽  
Prescription Opioid ◽  
Term Therapy ◽  
Epigenetic Alterations ◽  
Opioid Prescription ◽  
Peripheral Tissues ◽  
Prescription Opioid Misuse ◽  
Chronic Pain Conditions

Prescription opioids are used for some chronic pain conditions. However, generally, long-term therapy has unwanted side effects which may trigger addiction, overdose, and eventually cause deaths. Opioid addiction and chronic pain conditions have both been associated with evidence of genetic and epigenetic alterations. Despite intense research interest, many questions about the contribution of epigenetic changes to this typology of addiction vulnerability and development remain unanswered. The aim of this review was to summarize the epigenetic modifications detected in specific tissues or brain areas and associated with opioid prescription and misuse in patients who have initiated prescribed opioid management for chronic non-cancer pain. The review considers the effects of opioid exposure on the epigenome in central and peripheral tissues in animal models and human subjects and highlights the mechanisms in which opioid epigenetics may be involved. This will improve our current understanding, provide the basis for targeted, personalized pain management, and thus balance opioid risks and benefits in managing chronic pain.

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