scholarly journals Study Indicates Role of Alternate-Day Aspirin for Colorectal Cancer Prevention in Women

2013 ◽  
Vol 9 (5) ◽  
pp. 425-429
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prevention ◽  
Colorectal Cancer Prevention

Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: A clinical review and update

2008 ◽  
Vol 14 (2) ◽  
pp. 265-274 ◽  
Author(s):  
David T. Rubin ◽  
Marcia R. Cruz-Correa ◽  
Christoph Gasche ◽  
Jeremy R. Jass ◽  
Gary R. Lichtenstein ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Cancer Prevention ◽  
Clinical Review ◽  
Bowel Disease ◽  
Aminosalicylic Acid ◽  
Inflammatory Bowel ◽  
Colorectal Cancer Prevention

scholarly journals Potential role of probiotics on colorectal cancer prevention

BMC Surgery ◽  
2012 ◽  
Vol 12 (Suppl 1) ◽  
pp. S35 ◽  
Author(s):  
Mario Uccello ◽  
Giulia Malaguarnera ◽  
Francesco Basile ◽  
Velia D’agata ◽  
Michele Malaguarnera ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prevention ◽  
Potential Role ◽  
Colorectal Cancer Prevention

scholarly journals Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention

2013 ◽  
Vol 57 (11) ◽  
pp. 1908-1917 ◽  
Author(s):  
Soyoung Lim ◽  
Jianteng Xu ◽  
Jaeyong Kim ◽  
Tzu-Yu Chen ◽  
Xiaoyu Su ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prevention ◽  
Sweet Potato ◽  
Colorectal Cancer Prevention

Colorectal cancer prevention: screening and the role of aspirin

2013 ◽  
Vol 2 (5) ◽  
pp. 429-439 ◽  
Author(s):  
Peter C Elwood ◽  
William P Steward ◽  
Julieta Galante
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prevention ◽  
Colorectal Cancer Prevention

The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention

1995 ◽  
Vol 31 (7-8) ◽  
pp. 1071-1076 ◽  
Author(s):  
F.M Giardiello ◽  
G.J.A Offerhaus ◽  
R.N DuBois
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prevention ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Colorectal Cancer Prevention

scholarly journals Mechanisms of Colorectal Cancer Prevention by Aspirin—A Literature Review and Perspective on the Role of COX-Dependent and -Independent Pathways

2020 ◽  
Vol 21 (23) ◽  
pp. 9018
Author(s):  
Ranjini Sankaranarayanan ◽  
D. Ramesh Kumar ◽  
Meric A. Altinoz ◽  
G. Jayarama Bhat
Keyword(s):  
Salicylic Acid ◽  
Cancer Prevention ◽  
Protective Actions ◽  
Direct Exposure ◽  
Anti Cancer ◽  
Chemopreventive Effect ◽  
Colorectal Cancer Prevention ◽  
Preclinical And Clinical Studies ◽  
Shed Light

Aspirin, synthesized and marketed in 1897 by Bayer, is one of the most widely used drugs in the world. It has a well-recognized role in decreasing inflammation, pain and fever, and in the prevention of thrombotic cardiovascular diseases. Its anti-inflammatory and cardio-protective actions have been well studied and occur through inhibition of cyclooxygenases (COX). Interestingly, a vast amount of epidemiological, preclinical and clinical studies have revealed aspirin as a promising chemopreventive agent, particularly against colorectal cancers (CRC); however, the primary mechanism by which it decreases the occurrences of CRC has still not been established. Numerous mechanisms have been proposed for aspirin’s chemopreventive properties among which the inhibition of COX enzymes has been widely discussed. Despite the wide attention COX-inhibition has received as the most probable mechanism of cancer prevention by aspirin, it is clear that aspirin targets many other proteins and pathways, suggesting that these extra-COX targets may also be equally important in preventing CRC. In this review, we discuss the COX-dependent and -independent pathways described in literature for aspirin’s anti-cancer effects and highlight the strengths and limitations of the proposed mechanisms. Additionally, we emphasize the potential role of the metabolites of aspirin and salicylic acid (generated in the gut through microbial biotransformation) in contributing to aspirin’s chemopreventive actions. We suggest that the preferential chemopreventive effect of aspirin against CRC may be related to direct exposure of aspirin/salicylic acid or its metabolites to the colorectal tissues. Future investigations should shed light on the role of aspirin, its metabolites and the role of the gut microbiota in cancer prevention against CRC.

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