scholarly journals Platelet-activating factor receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Rebecca Hills ◽  
Satoshi Ishii ◽  
Sonia Jancar ◽  
Thomas McIntyre ◽  
Ewa Ninio ◽  
...  
Keyword(s):  
Platelet Activating Factor ◽  
Bacterial Lipopolysaccharide ◽  
Ether Phospholipid ◽  
Endogenous Ligands ◽  
Oxidized Phosphatidylcholine ◽  
Paf Receptor ◽  
Platelet Activating Factor Receptor

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles. The PAF receptor (provisional nomenclature recommended by NC-IUPHAR [37]) is activated by PAF and other suggested endogenous ligands are oxidized phosphatidylcholine [73] and lysophosphatidylcholine [96]. It may also be activated by bacterial lipopolysaccharide [89].

scholarly journals Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nathália Vieira Batista ◽  
Roberta Cristelli Fonseca ◽  
Denise Perez ◽  
Rafaela Vaz Sousa Pereira ◽  
Juliana de Lima Alves ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Food Allergy ◽  
Inflammatory Process ◽  
Platelet Activating Factor ◽  
Oral Challenge ◽  
Tissue Loss ◽  
Lack Of Information ◽  
Paf Receptor ◽  
Rolling Leukocytes

Platelet-activating factor (PAF) is known to be an important mediator of anaphylaxis. However, there is a lack of information in the literature about the role of PAF in food allergy. The aim of this work was to elucidate the participation of PAF during food allergy development and the consequent adipose tissue inflammation along with its alterations. Our data demonstrated that, both before oral challenge and after 7 days receiving ovalbumin (OVA) diet, OVA-sensitized mice lacking the PAF receptor (PAFR) showed a decreased level of anti-OVA IgE associated with attenuated allergic markers in comparison to wild type (WT) mice. Moreover, there was less body weight and adipose tissue loss in PAFR-deficient mice. However, some features of inflamed adipose tissue presented by sensitized PAFR-deficient and WT mice after oral challenge were similar, such as a higher rate of rolling leukocytes in this tissue and lower circulating levels of adipokines (resistin and adiponectin) in comparison to nonsensitized mice. Therefore, PAF signaling through PAFR is important for the allergic response to OVA but not for the adipokine alterations caused by this inflammatory process. Our work clarifies some effects of PAF during food allergy along with its role on the metabolic consequences of this inflammatory process.

Platelet-Activating Factor Receptor Signals in Rat Osteoblasts during Spaceflight

2004 ◽  
Vol 1030 (1) ◽  
pp. 116-120 ◽  
Author(s):  
YASUHIRO KUMEI ◽  
SADAO MORITA ◽  
HIROSHI NAKAMURA ◽  
HIDEO AKIYAMA ◽  
HISAKO KATANO ◽  
...  
Keyword(s):  
Platelet Activating Factor ◽  
Platelet Activating Factor Receptor ◽  
Rat Osteoblasts

Thrombin-Treated Endothelium Primes Neutrophil Functions: Inhibition by Platelet-Activating Factor Receptor Antagonists

1989 ◽  
Vol 45 (6) ◽  
pp. 483-490 ◽  
Author(s):  
G.M. Vercellotti ◽  
N.W.R. Wickham ◽  
K.S. Gustafson ◽  
H.Q. Yin ◽  
Mary Hebert ◽  
...  
Keyword(s):  
Platelet Activating Factor ◽  
Receptor Antagonists ◽  
Platelet Activating Factor Receptor
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