EVALUACIÓN DE LA GENOTOXICIDAD DE UNA SOPA INSTANTÁNEA COMERCIAL UTILIZANDO LA PRUEBA DE MICRONUCLEOS EN VICIA FABA Y RATÓN CD-1

2014 ◽  
Vol 7 ◽  
Author(s):  
Saúl Flores-Maya ◽  
Raul Ríos Torres ◽  
Sandra Gómez-Arroyo ◽  
Arturo Rosas Cipriano ◽  
Norberto Alarcón Herrera ◽  
...  
Keyword(s):  
Vicia Faba ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Statistical Significance ◽  
Chemical Compounds ◽  
Food Product ◽  
Peripheral Blood Cells ◽  
Market Demand ◽  
Root Cells ◽  
Mutagenic Effects

Due to the high market demand that instant soup has among the Mexican population, the question arose whether it may cause any mutagenic effects after its consumption. The aim of this study was to analyze the cyto-genotoxic effects caused after the exposure of this food product compounds to meristemal root cells of Vicia faba and to peripheral blood cells of CD-1 mice. To determine this effect, it was performed both analysis of micronuclei as well as toxicity degree by using these two biological models. The interpretation of our statistical significance tests (ANOVA and Dunnett’s multiple comparison p<0.05), allowed us to conclude that nor the soup chemical compounds neither the packaging induce clastogenic damage but they cause a slight delay on cell division to V. faba; nevertheless the compounds can cause clastogenic damage and cytotoxicity to peripheral blood cells of CD-1 mice.

Receptor Mediated Binding of the Fibrinolytic Components, Plasminogen and Urokinase, to Peripheral Blood Cells

1987 ◽  
Vol 58 (03) ◽  
pp. 936-942 ◽  
Author(s):  
Lindsey A Miles ◽  
Edward F Plow
Keyword(s):  
T Cells ◽  
B Cell ◽  
Peripheral Blood ◽  
Binding Sites ◽  
Blood Cells ◽  
High Capacity ◽  
Red Cells ◽  
Peripheral Blood Cells ◽  
Cellular Functions ◽  
Fibrinolytic Proteins

SummaryGlu-plasminogen binds to platelets; the monocytoid line, U937, and the human fetal fibroblast line, GM1380 bind both plasminogen and its activator, urokinase. This study assesses the interaction of these fibrinolytic proteins with circulating human blood cells. Plasminogen bound minimally to red cells but bound saturably and reversibly to monocytes, granulocytes and lymphocytes with apparent Kd values of 0.9-1.4 μM. The interactions were of high capacity with 1.6 to 49 × 105 sites/cell and involved the lysine binding sites of plasminogen. Both T cells and non-rosetting lymphocytes and two B cell lines saturably bound plasminogen. Urokinase bound saturably to gianulocytes, monocytes, non-rosetting lymphocytes and a B cell line, but minimally to T cells, platelets and red cells. Therefore, plasminogen binding sites of high capacity, of similar affinities, and with common recognition specificities are expressed by many peripheral blood cells. Urokinase receptors are also widely distributed, but less so than plasminogen binding sites. The binding ol plasminogen and/ or urokinase to these cells may lead to generation of cell- associated proteolytic activity which contributes to a variety of cellular functions.

scholarly journals RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease

2020 ◽  
Vol 11 ◽  
Author(s):  
Miguel A. Andrade-Navarro ◽  
Katja Mühlenberg ◽  
Eike J. Spruth ◽  
Nancy Mah ◽  
Adrián González-López ◽  
...  
Keyword(s):  
Gene Expression ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Trinucleotide Repeat ◽  
Neurodegenerative Disorder ◽  
Gene Expression Signature ◽  
Interferon Response ◽  
Peripheral Blood Cells

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the Huntingtin gene. As disease-modifying therapies for HD are being developed, peripheral blood cells may be used to indicate disease progression and to monitor treatment response. In order to investigate whether gene expression changes can be found in the blood of individuals with HD that distinguish them from healthy controls, we performed transcriptome analysis by next-generation sequencing (RNA-seq). We detected a gene expression signature consistent with dysregulation of immune-related functions and inflammatory response in peripheral blood from HD cases vs. controls, including induction of the interferon response genes, IFITM3, IFI6 and IRF7. Our results suggest that it is possible to detect gene expression changes in blood samples from individuals with HD, which may reflect the immune pathology associated with the disease.

Transplantation of Bone Marrow as Compared with Peripheral-Blood Cells from HLA-Identical Relatives in Patients with Hematologic Cancers

2001 ◽  
Vol 344 (3) ◽  
pp. 175-181 ◽  
Author(s):  
William I. Bensinger ◽  
Paul J. Martin ◽  
Barry Storer ◽  
Reginald Clift ◽  
Steven J. Forman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells

scholarly journals Differentiation potential of human suspension mononucleated peripheral blood cells

2011 ◽  
Vol 10 (52) ◽  
pp. 10756-10764 ◽  
Author(s):  
Ab Kadir Ruzanna ◽  
Hisham Zainal Ariffin Shahrul ◽  
Megat Abdul Wahab Rohaya ◽  
Senafi Sahidan ◽  
Zaman Huyop Fahrul
Keyword(s):  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Differentiation Potential
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