scholarly journals Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review

2021 ◽  
Author(s):  
Vinoo Subramaniam Ramachandran ◽  
Mensudar Rathakrishnan ◽  
Malathy Balaraman Ravindrran ◽  
Alargarsamy Venkatesh ◽  
Vidhya Shankari Shanmugasundaram ◽  
...  
Keyword(s):  
Cell Wall ◽  
Immune Surveillance ◽  
Lipoteichoic Acid ◽  
The Body ◽  
Gram Positive ◽  
Gram Negative ◽  
Cell Wall Components ◽  
Root Canals ◽  
Endodontic Infection ◽  
Wall Components

Bacteria and its by-products are found to be the main cause of pulpal and periapical infection of tooth. Infected root canals of tooth harbours a wide variation of microbial flora that includes both Gram-positive and Gram-negative microorganisms. Bacterial components such as Lipopolysaccharide (LPS) of gram negative bacteria and Lipoteichoic Acid (LTA) of gram positive bacteria have the potential to enter the peri-apical tissue of tooth and initiate the inflammatory process. After microbial death that occurs either due to body’s defence cells or by antibiotic action, bacterial cell wall components such as LTA are released which can persist inside macrophages for prolonged periods causing chronic inflammation. Once these cell-wall components are recognized by the body immune surveillance cells, numerous inflammatory mediators are released leading to inflammation and subsequent pathological consequences. The purpose of this review is intend to summarize the role of gram positive bacterial component LTA in causing endodontic infection and use of potential therapeutic agents against LTA.

scholarly journals Characteristics of Surfactant Protein A and D Binding to Lipoteichoic Acid and Peptidoglycan, 2 Major Cell Wall Components of Gram‐Positive Bacteria

2001 ◽  
Vol 184 (9) ◽  
pp. 1143-1151 ◽  
Author(s):  
J. Koenraad van de Wetering ◽  
Martin van Eijk ◽  
Lambert M. G. van Golde ◽  
Thomas Hartung ◽  
Jos A. G. van Strijp ◽  
...  
Keyword(s):  
Cell Wall ◽  
Protein A ◽  
Lipoteichoic Acid ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Gram Positive ◽  
Cell Wall Components ◽  
Gram Positive Bacteria ◽  
Wall Components

scholarly journals Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Immunity ◽  
1999 ◽  
Vol 11 (4) ◽  
pp. 443-451 ◽  
Author(s):  
Osamu Takeuchi ◽  
Katsuaki Hoshino ◽  
Taro Kawai ◽  
Hideki Sanjo ◽  
Haruhiko Takada ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Gram Positive ◽  
Gram Negative ◽  
Cell Wall Components ◽  
Wall Components

scholarly journals Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tsukasa Tominari ◽  
Ayumi Sanada ◽  
Ryota Ichimaru ◽  
Chiho Matsumoto ◽  
Michiko Hirata ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Osteoclast Differentiation ◽  
Lipoteichoic Acid ◽  
Alveolar Bone Loss ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

AbstractPeriodontitis is an inflammatory disease associated with severe alveolar bone loss and is dominantly induced by lipopolysaccharide from Gram-negative bacteria; however, the role of Gram-positive bacteria in periodontal bone resorption remains unclear. In this study, we examined the effects of lipoteichoic acid (LTA), a major cell-wall factor of Gram-positive bacteria, on the progression of inflammatory alveolar bone loss in a model of periodontitis. In coculture of mouse primary osteoblasts and bone marrow cells, LTA induced osteoclast differentiation in a dose-dependent manner. LTA enhanced the production of PGE2 accompanying the upregulation of the mRNA expression of mPGES-1, COX-2 and RANKL in osteoblasts. The addition of indomethacin effectively blocked the LTA-induced osteoclast differentiation by suppressing the production of PGE2. Using ex vivo organ cultures of mouse alveolar bone, we found that LTA induced alveolar bone resorption and that this was suppressed by indomethacin. In an experimental model of periodontitis, LTA was locally injected into the mouse lower gingiva, and we clearly detected alveolar bone destruction using 3D-μCT. We herein demonstrate a new concept indicating that Gram-positive bacteria in addition to Gram-negative bacteria are associated with the progression of periodontal bone loss.

Sign in / Sign up

Export Citation Format

Share Document