scholarly journals Modulation of long-term potentiation by the glycine site of N-methyl-D-aspartate receptor in rat hippocampal CA1 pyramidal cells

2004 ◽  
Author(s):  
Nicholas Krasteniakov
Keyword(s):  
Pyramidal Cells ◽  
Long Term Potentiation ◽  
Glycine Site ◽  
Ca1 Pyramidal Cells ◽  
Aspartate Receptor ◽  
Term Potentiation ◽  
Hippocampal Ca1

scholarly journals Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells.

1996 ◽  
Vol 93 (16) ◽  
pp. 8710-8715 ◽  
Author(s):  
J. T. Isaac ◽  
G. O. Hjelmstad ◽  
R. A. Nicoll ◽  
R. C. Malenka
Keyword(s):  
Pyramidal Cells ◽  
Long Term Potentiation ◽  
Single Fiber ◽  
Ca1 Pyramidal Cells ◽  
Term Potentiation ◽  
Hippocampal Ca1

scholarly journals Selective Induction of LTP and LTD by Postsynaptic [Ca2+]i Elevation

1999 ◽  
Vol 81 (2) ◽  
pp. 781-787 ◽  
Author(s):  
Shao-Nian Yang ◽  
Yun-Gui Tang ◽  
Robert S. Zucker
Keyword(s):  
Calcium Concentration ◽  
Pyramidal Cells ◽  
Long Term Potentiation ◽  
Biological Information ◽  
Synaptic Modulation ◽  
Ca1 Pyramidal Cells ◽  
Caged Calcium ◽  
Term Potentiation ◽  
Calcium Compound

Selective Induction of LTP and LTD by Postsynaptic [Ca2+]i Elevation. Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca2+]i). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(β-aminoethyl ether)- N, N, N′, N′-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca2+]i elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca2+]i with relatively high magnitude, which mimics the [Ca2+]i rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca2+]i reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information.

scholarly journals (2S,6S)- and (2R,6R)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice

2020 ◽  
Vol 4 ◽  
pp. 239821282095784
Author(s):  
Heather Kang ◽  
Pojeong Park ◽  
Muchun Han ◽  
Patrick Tidball ◽  
John Georgiou ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Long Term Potentiation ◽  
Aspartate Receptor ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Mouse Hippocampus ◽  
Site Of Action ◽  
A Site

The ketamine metabolite (2 R,6 R)-hydroxynorketamine has been proposed to have rapid and persistent antidepressant actions in rodents, but its mechanism of action is controversial. We have compared the ability of ( R,S)-ketamine with the (2 S,6 S)- and (2 R,6 R)-isomers of hydroxynorketamine to affect the induction of N-methyl-d-aspartate receptor–dependent long-term potentiation in the mouse hippocampus. Following pre-incubation of these compounds, we observed a concentration-dependent (1–10 μM) inhibition of long-term potentiation by ketamine and a similar effect of (2 S,6 S)-hydroxynorketamine. At a concentration of 10 μM, (2 R,6 R)-hydroxynorketamine also inhibited the induction of long-term potentiation. These findings raise the possibility that inhibition of N-methyl-d-aspartate receptor–mediated synaptic plasticity is a site of action of the hydroxynorketamine metabolites with respect to their rapid and long-lasting antidepressant-like effects.

Dietary Prenatal Choline Supplementation Alters Postnatal Hippocampal Structure and Function

2004 ◽  
Vol 91 (4) ◽  
pp. 1545-1555 ◽  
Author(s):  
Qiang Li ◽  
Shirley Guo-Ross ◽  
Darrell V. Lewis ◽  
Dennis Turner ◽  
Aaron M. White ◽  
...  
Keyword(s):  
Pyramidal Cells ◽  
Long Term Potentiation ◽  
Prenatal Development ◽  
Structure And Function ◽  
Cellular Mechanisms ◽  
Ca1 Pyramidal Cells ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Essential Nutrient ◽  
And Function

Choline, a compound present in many foods, has recently been classified as an essential nutrient for humans. Studies with animal models indicate that the availability of choline during the prenatal period influences neural and cognitive development. Specifically, prenatal choline supplementation has been shown to enhance working memory and hippocampal long-term potentiation (LTP) in adult offspring. However, the cellular mechanisms underlying these effects remain unclear. Here we report that choline supplementation, during a 6-day gestational period, results in greater excitatory responsiveness, reduced slow afterhyperpolarizations (sAHPs), enhanced afterdepolarizing potentials (ADPs), larger somata, and greater basal dendritic arborization among hippocampal CA1 pyramidal cells studied postnatally in juvenile rats (20–25 days of age). These data indicate that dietary supplementation with a single nutrient, choline, during a brief, critical period of prenatal development, alters the structure and function of hippocampal pyramidal cells.

Long-term potentiation at the apical and basal dendritic synapses of CA1 after local stimulation in behaving rats

1995 ◽  
Vol 73 (5) ◽  
pp. 1938-1946 ◽  
Author(s):  
L. S. Leung ◽  
B. Shen
Keyword(s):  
High Frequency ◽  
Pyramidal Cells ◽  
Long Term Potentiation ◽  
Ca1 Pyramidal Cells ◽  
Stratum Oriens ◽  
Term Potentiation ◽  
Theta Frequency ◽  
Freely Behaving ◽  
Local Stimulation

1. We recorded the extracellular excitatory postsynaptic potentials (EPSPs) in CA1 in the freely behaving rats after stimulation of the apical dendritic and basal dendritic afferents. The apical dendritic population EPSP was negative at the apical dendritic layers and positive at stratum oriens and alveus. The basal dendritic population EPSP was negative at basal dendritic layer (stratum oriens) and positive at the cell body and apical dendritic layers. 2. We delivered various tetanic stimulus patterns in an attempt to elicit long-term potentiation (LTP) at the apical dendritic synapse of CA1 pyramidal cells. A 200-Hz high-frequency train (HF) 1 s in duration was more successful than theta-frequency primed bursts (PBs; 1 or 4 priming pulses followed by 10 or 4 pulses at 100 Hz) in eliciting LTP of the apical dendritic population EPSP, recorded either ipsilaterally or contralaterally. 3. Tetanus applied to the apical dendritic afferents occasionally elicited long-term depression (LTD) at an intensity lower than the LTP threshold. LTD persisted to > or = 1 day after a tetanus. 4. High-intensity tetanic stimulations often elicited hippocampal afterdischarges (ADs). If the AD duration was brief (< 15 s), apical dendritic LTP could follow the AD. However, if the AD duration was long, no apical dendritic LTP was observed. Tetanus that evoked an apical dendritic LTP typically evoked a short hippocampal AD < 15 s in duration. 5. LTP of the basal dendritic population EPSP was readily elicited either after an HF or a PB tetanus of low (1.5-2 times threshold) stimulus intensity.(ABSTRACT TRUNCATED AT 250 WORDS)

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