scholarly journals Preparation and Evaluation of Beta sitosterol Nanogel: A Carrier Design for Targeted Drug Delivery system

2018 ◽  
Vol 6 (3) ◽  
pp. 81-87
Author(s):  
Yashashri Mohan Inamdar ◽  
Bhushan Rane ◽  
Ashish Jain
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Drug Loading ◽  
Drug Formulation ◽  
Gelling Agent ◽  
Therapeutic Effects ◽  
Transdermal Drug Delivery System

Transdermal drug delivery system is promising but challenging system available for local as well as systemic effect of the drug. The prolonged residence of drug formulation in the skin is important for transdermal drug delivery. Nanogel drug delivery has remained as one of the most challenging task. The objective of the investigation was to develop a nanogel with reduced particle size in order to improve the bioavailability of the hydrophobic drug. The objective of the controlled and sustained delivery is to provide and maintained adequate concentration of drugs at the site of action. Nanogels based materials have high drug loading capacity, biocompatibility and biodegradability which are key points to design the drug delivery system effectively. Drug molecules loaded into the nanogel need to be retained and not to be transported out or leak prematurely while circulating in order to provide maximum therapeutic effects and minimum toxicity or side effects. The present study is to formulate nanosizes dispersion of Beta sitosterol by nanoprecipitation method and incorporating it into the gelling agent to produce nanogel by dispersion method. 1% of carbopol 934 shows better in-vitro drug release than the other concentrations of carbopol 934.

scholarly journals FORMULATION AND DEVELOPMENT OF TRANSDERMAL DRUG DELIVERY SYSTEM OF ETHINYLESTRADIOL AND TESTOSTERONE: IN VITRO EVALUATION

2019 ◽  
Vol 11 (1) ◽  
pp. 55
Author(s):  
Shikha Baghel Chauhan ◽  
Tanveer Naved ◽  
Nayyar Parvez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Physical Parameters ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
In Vitro Skin Permeation

Objective: The combination therapy of ethinylestradiol and testosterone in post-menopausal females has shown improved sexual response and libido. The present studies were designed to develop a suitable matrix-type transdermal drug delivery system (TDDS) of ethinylestradiol and testosterone using the polymer chitosan.Methods: Five formulations (ET1 to ET5) were developed by varying the concentration of polymer and keeping the drug load constant. Physical parameters and drug excipient interaction studies were evaluated in all the formulations. In vitro skin permeation profiles of ethinylestradiol and testosterone from various formulations were simultaneously characterized in a thermostatically controlled modified Franz Diffusion cell using HPLC. Based on the physical parameters and in vitro skin permeation profile formulation ET3 containing 30 mg/ml of chitosan was found to be the best and chosen for further studies. Optimized formulation was subjected to in vivo pharmacokinetic analysis in rats using ELISA.Results: Stability profile of patch formulation ET3 depicted stability up to 3 mo. One week skin irritation evaluation in rats indicated that formulation ET3 was nonirritating. Combination transdermal patch across rat skin showed a maximum release of 92.936 and 95.03 % in 60 h with a flux of 2.088 and 21.398 µg/cm2h for ethinylestradiol and testosterone respectively.Conclusion: The net result of this study is the formulation of a stable, non-irritating transdermal patch of ethinylestradiol and testosterone, with good bioavailability and can be used as Estrogen Replacement Therapy (ERT) in postmenopausal women.

Formulation and in vitro evaluation of transdermal drug delivery system for donepezil

2012 ◽  
Vol 42 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Robhash Kusam Subedi ◽  
Je-Phil Ryoo ◽  
Cheol Moon ◽  
Myung-Kwan Chun ◽  
Hoo-Kyun Choi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
In Vitro Evaluation

scholarly journals IMPROVING TRANSDERMAL DRUG DELIVERY SYSTEM FOR MEDROXYPROGESTERONE ACETATE BY OLIVE OIL AND DIMETHYLSULFOXIDE (DMSO) AS PENETRATION ENHANCERS: IN VITRO PENETRATION STUDY

2020 ◽  
pp. 12-15
Author(s):  
CAMELIA DWI PUTRI MASRIJAL ◽  
HARMITA HARMITA ◽  
ISKANDARSYAH ISKANDARSYAH
Keyword(s):  
Drug Delivery ◽  
Olive Oil ◽  
Drug Delivery System ◽  
Delivery System ◽  
Medroxyprogesterone Acetate ◽  
Transdermal Drug Delivery ◽  
Penetration Enhancers ◽  
Penetration Test ◽  
Transdermal Drug Delivery System

Objective: Medroxyprogesterone Acetate (MPA) using a transdermal drug delivery system for contraception by passive diffusion is limited by the skin barrier properties. Penetration enhancers such as olive oil (fatty acid permeation enhancer) and DMSO (chemical enhancer) can be used. The objective of this study was to overcome MPA penetration problem by using olive oil and DMSO. Methods: An in vitro penetration study using the Franz diffusion cells was performed. The first penetration study used MPA in olive oil (O) and MPA in coconut oil (C) with the concentration 100 μg/ml to each sample and MPA suspension as a control with the same concentration. The second study used MPA in olive oil with the concentration 200.0 μg/ml (A), MPA in olive oil with 0.5% DMSO with the concentration 200.0 μg/ml (B), and MPA in olive oil with 1% DMSO with the concentration 200 μg/ml (C). Results: MPA penetration test for olive oil+0.5% DMSO had flux value 4.24±0.074 μg/cm2. hr and it was not significantly different (t-test, P>0.05) with olive oil+1% DMSO. While the MPA penetration test in only Olive oil had flux value 0.90±0.0087 μg/cm2. hr. Conclusion: This research concluded that olive oil and 0.5% DMSO could improve the penetration of MPA into skin membrane by 4.5 times more than olive oil alone.

Niosomes as transdermal drug delivery system for celecoxib: in vitro and in vivo studies

2015 ◽  
Vol 73 (5) ◽  
pp. 1229-1245 ◽  
Author(s):  
Sayed H. Auda ◽  
Dina Fathalla ◽  
Gihan Fetih ◽  
Mahmoud El-Badry ◽  
Faiyaz Shakeel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
In Vivo Studies ◽  
Transdermal Drug Delivery System

Formulation and evaluation of Clopidogrel bisulfate loaded transdermal patches for anti-platelet activity

2018 ◽  
Vol 9 (1) ◽  
pp. 25
Author(s):  
Subramanian S ◽  
Senith SK
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
In Vitro Drug Release ◽  
Clopidogrel Bisulfate ◽  
Transdermal Patches

Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Orally clopidogrel bisulfate has a short elimination half-life (7-8 h), low oral bioavailability (50 %) undergoes extensive first pass metabolism (85 %) and frequent high doses (75 mg) are required to maintain the therapeutic level as a result. The purpose of this research was formulation and evaluation of transdermal drug delivery system of clopidogrel bisulfate using various polymers such as HPMC and EC by solvent casting technique for improvement of bioavailability of drug and reducing toxic effects. The developed transdermal patches may increase the therapeutic efficacy and reduce toxic effect of clopidogrel bisulfate. The prepared transdermal drug delivery system of clopidogrel bisulfate using different polymers such as HPMC and EC had shown good & promising results for all the evaluated parameters. Based on the in vitro drug release, drug content, weight variation, tensile strength, thickness and folding endurance results formulation F2 was concluded as an optimized formulation which shows its higher percentage of drug release. Keyword: Clopidogrel bisulfate; Transdermal patch; TDDS; Solvent evaporation; In vitro drug release

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