scholarly journals Pharmacological evaluation of Chloroxylonswietenia DC bark extract on alloxan induced Diabetic nephropathy in Wistar rats

2019 ◽  
Vol 7 (2) ◽  
pp. 15-22
Author(s):  
Manpreet Kaur ◽  
Amit Sharma ◽  
Madan Kaushik
Keyword(s):  
Diabetic Nephropathy ◽  
Wistar Rats ◽  
Bark Extract ◽  
Pharmacological Evaluation

Diabetes is now a days consider as common problem with serious issues. Diabetes cause various other dysfunctions and issues in various organs and parts of bodies, so it should be cured and treated. Chloroxylonswietenia DC bark extract proved to be helpful in treating diabetic problems. It is highly available and can cure various other problems caused by diabetes in bodies. In present study we have studied various properties, functions, effects, of extracts of Chloroxylonswietenia DC bark extracton alloxan induced Diabetic nephropathy in Wistar rats.

scholarly journals PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ANTI- AMNESIC EFFECT OF MORUS ALBA LINN IN WISTAR RATS

2018 ◽  
Author(s):  
HemanthKumar B ◽  
Prathibha R ◽  
Manohari R ◽  
Aswini S ◽  
Sai priya R ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Morus Alba ◽  
Amnesic Effect ◽  
Pharmacological Evaluation

scholarly journals Ameliorating effects of Cissus populnea aqueous stem bark extract on some parameters in diabetic Wistar rats

2021 ◽  
Vol 3 (2) ◽  
pp. 107
Author(s):  
Aondoaseer Kasar ◽  
Ndubisi A Chidi ◽  
Adilieje Chioma M ◽  
Ibegbu Madu D
Keyword(s):  
Wistar Rats ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract

Neuroprotective Effects of the Anthocleista Schweinfurthii Gilg. (Loganiaceae) Stem Bark Extract in Postmenopause-Like Model of Ovariectomized Wistar Rats

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Ngoungoure Madeleine Chantal ◽  
Dzeufiet Djomeni Paul Désiré ◽  
Bilanda Danielle Caude ◽  
Mengue Ngandena Yolande Sandrine ◽  
Mbolang Nguegang Lohik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plant Extract ◽  
Total Protein ◽  
Wistar Rats ◽  
Stem Bark ◽  
Bark Extract ◽  
Estradiol Valerate ◽  
Neuroprotective Effects ◽  
Protein Levels ◽  
Stem Bark Extract

Abstract Background Estrogen deficiency in postmenopausal period causes severe neuroendocrine changes in brain which influences memory and other nervous functions. Anthocleista schweinfurthii is used traditionally to treat female infertility and menopause related symptoms. This study was performed to investigate the potential neuroprotective effects of aqueous extract of Anthocleista schweinfurthii on brain in a postmenopause-like model of ovariectomized Wistar rats. Methods Thirty animals were sham-operated or ovariectomized (Ovx) 84 days after surgery, six groups of five rats each were daily treated orally during 28 days with: distilled water for groups 1 (sham-operated) and 2 (Ovx), estradiol valerate (group 3) and the three doses of extracts {groups 4, 5 and 6 (Ovx)}. Biochemical and histological evaluations focused on brain. Results Compared to sham-operated control, ovariectomy decreased total protein levels in brain (p<0.01) which was increased by plant extract at the dose of 300 mg/kg (p<0.05), underlying its anabolic properties. Ovariectomy significantly decreased magnesium levels in brain (p<0.001). Anthocleista schweinfurthii increased significantly magnesium levels (p<0.01), showing its capacity to act on synaptic conduction. Ovariectomy induced oxidative stress by increasing malondialdehyde levels (p<0.05) and decreasing reduced glutathione levels (p<0.05) in brain. The plant extract exhibited antioxidative activity by reducing malondialdehyde levels and increasing glutathione levels in brain. Damage in brain structure which was caused by ovariectomy disappeared following the treatment. Conclusions Results suggest that Anthocleista schweinfurthii may have neuroprotective effects in Ovx Wistar rats by increasing total protein, magnesium levels and reducing oxidative stress in brain.

scholarly journals Reduction of podocytes number in late diabetic alloxan nephropathy: prevention by glycemic control

2007 ◽  
Vol 22 (5) ◽  
pp. 337-341 ◽  
Author(s):  
Célia Sperandéo Macedo ◽  
Mauro Masson Lerco ◽  
Sônia Maria Capelletti ◽  
Reinaldo José Silva ◽  
Daniela de Oliveira Pinheiro ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Diabetic Nephropathy ◽  
Glycemic Control ◽  
Wistar Rats ◽  
Treated Group ◽  
Renal Tissue ◽  
Diabetic Rats ◽  
Gbm Thickening ◽  
Diabetes Induction

PURPOSE: To determine podocyte number and GBM thickness in diabetic rats either under glycemic control or without glycemic control at 6 and 12 months after diabetes induction. METHODS: 100 wistar rats weighing 200-300g were divided into 6 groups: Normal group (N6 and N12- 25 rats); Diabetic group (D6 and D12- 25 rats), diabetic treated group ( DT 6 and DT 12- 25 rats) on insulin 1,8- 3,0 IU/Kg associated with acarbose (50mg to 100g of food) daily mixed in chow. Alloxan was injected intravenously in a dose of 42 mg/Kg of weight. Body weight, waterintake, 24-h diuresis, glycemia and glucosuria were determined before induction, 7 and 14 days after induction and monthly thereafter. Treatment started at day 14. Three groups were sacrificed at 6 months (N6,D6, DT6) and 3 groups at 12 months (N12, D12, DT12) with the renal tissue being prepared for electron microscopy. RESULTS: Glycemia in DT6¨and in DT12 was significantly different from that in D6 and D12 rats and similar to that in N6 and N12 animals. The number of podocytes in DT6 was not different from that in N6 and D6 (median = 11); the number of podocytes in DT12 (median = 11) differed from that in D12 (median = 8), but not from that in N12 (median = 11). GBM thickness in D6 (0.18 micrometers) was lower than in D12 (0.29 micrometers); while in DT6 (0.16 micrometers) it was lower than in D6 (0.18 micrometers). In DT12 (0.26 micrometers), it was lower than in D12 (0.29 micrometers). CONCLUSION: The control of hyperglycemia prevented GBM thickening in early and late (12 mo) alloxan diabetic nephropathy and podocyte number reduction.

Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c

2019 ◽  
Vol 38 (10) ◽  
pp. 1134-1142 ◽  
Author(s):  
Zahra Ebadi ◽  
Nariman Moradi ◽  
Toktam Kazemi Fard ◽  
Tourandokht Balochnejadmojarrad ◽  
Elham Chamani ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Wistar Rats

Renoprotective potential of dimethyl fumarate in streptozotocin induced diabetic nephropathy in Wistar rats

2020 ◽  
Vol 18 ◽  
pp. 100237
Author(s):  
Aamir Lone ◽  
Tapan Behl ◽  
Arun Kumar ◽  
Rashita Makkar ◽  
Priya Nijhawan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Wistar Rats ◽  
Dimethyl Fumarate
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