scholarly journals Antioxidant and antifungal activity of Geophila repens (L.) I. M. Johnst. (Rubiaceae)

2018 ◽  
Vol 8 (5) ◽  
pp. 268-272
Author(s):  
BK Sahana ◽  
Shahneel Akhilesha ◽  
GS Priyanka ◽  
TR Prashith Kekuda
Keyword(s):  
Antifungal Activity ◽  
Leaf Extract ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Ic50 Value ◽  
Antifungal Potential ◽  
Reducing Activity ◽  
Poisoned Food Technique ◽  
Free Radical Scavenging Assay ◽  
Radical Scavenging Assay

Objectives: The present study was conducted to investigate the potential of leaf extract of Geophila repens (L.) I.M. Johnst. (Rubiaceae) to exhibit antioxidant and antifungal potential. Methods: Extraction of powdered leaf material was carried out by maceration process using methanol. Antioxidant activity of leaf extract was assessed by DPPH free radical scavenging assay and ferric reducing assay. Antifungal activity of leaf extract was determined by Poisoned food technique. Results: Leaf extract was shown to scavenge DPPH radicals dose dependently with IC50 value of 51.39µg/ml. An increase in the absorbance on increasing concentration of leaf extract indicated ferric reducing activity. The extract showed more or less similar inhibitory activity against Aspergillus niger and Bipolaris sp. (>50% inhibition). Conclusion: The results of the study indicate that leaf extract possesses bioactive principles with activity against oxidative damage and seed-borne fungi which are to be purified and screened for antioxidant and antifungal activity. Keywords: Geophila repens, Maceration, DPPH, Ferric reducing, Seed-borne fungi, Poisoned food technique

scholarly journals BIOACTIVITY SCREENING OF SELECTED TRADITIONAL MEDICINAL PLANTS OF KERALA

2018 ◽  
Vol 11 (12) ◽  
pp. 339
Author(s):  
Alby Alphons Baby ◽  
Regi Raphael K
Keyword(s):  
Free Radical ◽  
Medicinal Plants ◽  
Superoxide Anion ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Significant Activity ◽  
Traditional Use ◽  
Ic50 Value ◽  
Free Radical Scavenging Assay ◽  
Radical Scavenging Assay

Objectives: Traditional medicines all over the world is revaluing nowadays by extensive research programs. To validate the traditional use, the active components in them need to be identified, characterized, and biologically evaluated. Stereospermum suaveolens, Hygrophila spinosa, and Naravelia zeylanica are important medicinal plants used by the ethnic people of Kerala against various ailments. The present study validates the ethnomedical uses of S. suaveolens, H. spinosa, and N. zeylanica by screening their antimicrobial, anthelmintic, and antioxidant properties.Method: All the analyses were done according to standard protocols.Results: The ethanolic extracts of their useful parts were investigated for antimicrobial activity against 10 human pathogenic microorganisms. All the three plants had shown prominent antimicrobial activities, and S. suaveolens exhibits comparatively more antifungal activity in their higher concentration (500 μg/mL). Anthelmintic efficiency of the plants was screened using Indian adult earthworm Pheretima posthuma. All of them had shown significant activity, and the highest was observed in S. suaveolens leaves. Antioxidant potential of the plants was screened using 2,2 diphenyl 1-picrylhydrazyl (DPPH) free radical scavenging assay and superoxide anion scavenging assay. In DPPH free radical scavenging assay, maximum radical scavenging was shown by S. suaveolens with IC50 value 61.6±2.3 μg/mL, and in superoxide anion scavenging assay, maximum activity was in N. zeylanica with IC50 value of 74.66±8.5 μg/mL.Conclusion: This study provides scientific evidence on the traditional use of S. suaveolens (leaves), H. spinosa (leaves), and N. zeylanica (aerial part) in treating microbial diseases, worm disturbances, and their potential as an antioxidant agent.

scholarly journals In –vitro Antioxidant Activity of Methanolic Extract of the Roots of Bergenia ciliata

2018 ◽  
Vol 1 (4) ◽  
pp. 31-34
Author(s):  
Suman Lal Shrestha ◽  
Suresh Awale ◽  
Surya Kant Kalauni
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Methanolic Extract ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Ic50 Value ◽  
Free Radical Scavenging Assay ◽  
Radical Scavenging Assay ◽  
In Vitro Antioxidant Activity

Bergenia ciliata is an essential medicinal plant used in regions where western medicines are inaccessible due to their unavailability and high cost. The methanolic extract of Bergenia ciliataroots was separated for phytochemical elements and in-vitro antioxidant activity. The plant extract showed the rich outgrowth of secondary metabolites that play the role for biological activities. The higher antioxidant functioning of the plant is due to the occurrence of reactive elements like phenols and flavonoids. The antioxidant functioning of the plant extract was measured by DPPH free radical scavenging assay. In DPPH free radical scavenging assay the IC50 value of Bergenia ciliata was found to be 11.21μg/mL, while the IC50 value of standard ascorbic acid was found to be 45.93μg/mL

scholarly journals Synthesis and Antioxidant Activity of Some Novel Benzimidazole Derivatives

2018 ◽  
Vol 16 (2) ◽  
pp. 245-249 ◽  
Author(s):  
Nilima Karmaker ◽  
Dilshad Noor Lira ◽  
Biplab Kumar Das ◽  
Uttom Kumar ◽  
Abu Shara Shamsur Rouf
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Spectroscopic Data ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Benzimidazole Derivatives ◽  
Ic50 Value ◽  
Substituted Benzaldehydes ◽  
Free Radical Scavenging Assay ◽  
Radical Scavenging Assay

A series of 2-substituted-5-methylbenzimidazole derivatives (3a-e) were synthesized by reacting   4-methyl-1,2-phenylenediamine (1) with a number of p-substituted benzaldehydes (2a-e) in moderate yields (25.51-   40.21%). The synthesized compounds (3a-e) were characterized by spectroscopic data and were evaluated for   antioxidant activity using DPPH free radical scavenging assay. The compounds showed significant antioxidant   activity having IC50 value of 1.054-19.05 μg/ml as compared to the standard BHT (26.96 μg/ml).Dhaka Univ. J. Pharm. Sci. 16(2): 245-249, 2017 (December)

scholarly journals In-vitro antimicrobial and antioxidant activity of Argyreia cuneata (Willd.) Ker Gawl. (Convolvulaceae)

2018 ◽  
Vol 8 (6) ◽  
pp. 22-27
Author(s):  
TR Prashith Kekuda ◽  
Nitish A. Bharadwaj ◽  
MB Sachin ◽  
BK Sahana ◽  
GS Priyanka
Keyword(s):  
Antioxidant Activity ◽  
Antifungal Activity ◽  
Leaf Extract ◽  
Shigella Flexneri ◽  
Radical Scavenging ◽  
Flower Extract ◽  
Stem Extract ◽  
Poisoned Food Technique ◽  
Antimicrobial And Antioxidant Activity

Objectives: Argyreia cuneata (Willd.) Ker Gawl. belongs to the family Convolvulaceae. The present study was performed to screen the potential of crude extract of various parts of A. cuneata to exhibit antimicrobial activity. Methods: Extraction of shade dried and powdered leaf, stem and flower of A. cuneata was carried out by maceration technique. Antibacterial and antifungal activity of extracts was evaluated by Agar well diffusion and Poisoned food technique respectively. Antioxidant activity was determined by DPPH radical scavenging, ABTS radical scavenging and ferric reducing assays. Results:  All extracts were effective in inhibiting test bacteria and the susceptibility of bacteria to extracts was in the order: Bacillus cereus > Shigella flexneri > Escherichia coli > Salmonella typhimurium. Leaf extract and stem extract exhibited highest and least antibacterial activity, respectively. Extracts were effective in causing inhibition of seed-borne fungi viz. Aspergillus niger and Bipolaris sp to >50%. Leaf extract exhibited marked antifungal activity followed by flower extract and stem extract. All extracts were shown to exhibit concentration dependent scavenging and reducing activity. Antioxidant activity of extracts observed was in the order: leaf extract > flower extract > stem extract.  Conclusion: Among various parts of A. cuneata, leaf extract exhibited marked antimicrobial and antioxidant activity. The plant can be employed as an effective antimicrobial and antioxidant agent in suitable form. Further studies may be undertaken to recover phytochemicals from the plant and to investigate the antimicrobial and antioxidant activity of isolated components. Keywords: Argyreia cuneata, Maceration, Antimicrobial, Agar well diffusion, Poisoned food technique, Antioxidant

scholarly journals Antioxidant activities of traditional plants in Sri Lanka by DPPH free radical-scavenging assay

Data in Brief ◽  
2018 ◽  
Vol 17 ◽  
pp. 870-875 ◽  
Author(s):  
Kotaro Hara ◽  
Takao Someya ◽  
Katsura Sano ◽  
Yoshimasa Sagane ◽  
Toshihiro Watanabe ◽  
...  
Keyword(s):  
Free Radical ◽  
Sri Lanka ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Assay ◽  
Radical Scavenging Assay

In Vitro Regeneration and Free Radical Scavenging Assay of Hypericum perforatum L.

2018 ◽  
Vol 42 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Mohammad Yaseen Mir ◽  
Azra N. Kamili ◽  
Qazi P. Hassan ◽  
Sabreena Rafi ◽  
Javid A. Parray ◽  
...  
Keyword(s):  
Free Radical ◽  
Hypericum Perforatum ◽  
In Vitro Regeneration ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Hypericum Perforatum L ◽  
Free Radical Scavenging Assay ◽  
Radical Scavenging Assay
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