scholarly journals Antibiotic evaluation of odontogenic microbiological spectrum of orofacial infection

2018 ◽  
Vol 8 (6) ◽  
pp. 179-182
Author(s):  
Neha Vishnoi ◽  
Sapna Singh ◽  
Ram Singh Bishnoi ◽  
M K Gupta
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Drug Release Profile ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Compression Technique ◽  
Peg 6000 ◽  
Drug Content ◽  
Weight Variation ◽  
Enhanced Solubility

The present study aimed towards the development of active delivery system for management of hypertension. The Orodispersible tablets (ODTs) containing Telmisartan was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of Telmisartan and PEG 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of ODT system. A batch process was adopted for the preparation of solid dispersion with each combination of drug and polymer and the finally compressed as tablets by direct compression technique. For the preformulation perspective materials were scrutinized on the basis of solubility profile, drug content, Fourier Transform Infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC). The drug polymer ratio 1:4 was selected for further compression process. The prepared batches of ODTs were characterized for micromeritic study, thickness, hardness, weight variation, wetting time, disintegration time, drug content and in vitro drug release profile. The evaluation data for all batches was satisfactory out of them formulation TF3 containing 6% kyron T-314 showed the best results with a value of 29.3 sec and 24.1 sec for wetting and disintegration, respectively. This formulation showed superior drug release of 99.93% over a period of 30 minutes. Keywords: Telmisartan, PEG 6000, Angioten receptor-II antagonist, Solid dispersion, Kyron T-314

scholarly journals Development and optimization of orodispersible tablets using solid dispersion of Telmisartan

2018 ◽  
Vol 8 (6) ◽  
pp. 171-178
Author(s):  
RAMAKANT JOSHI ◽  
WASIM AKRAM ◽  
Navneet Garud ◽  
Ashutosh Dubey ◽  
Santosh Bhadkariya
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Drug Release Profile ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Compression Technique ◽  
Drug Content ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Enhanced Solubility

The present study aimed towards the development of active delivery system for management of hypertension. The Orodispersible tablets (ODTs) containing Telmisartan was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of Telmisartan and PEG 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of ODT system. A batch process was adopted for the preparation of solid dispersion with each combination of drug and polymer and the finally compressed as tablets by direct compression technique. For the preformulation perspective materials were scrutinized on the basis of solubility profile, drug content, Fourier Transform Infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC). The drug polymer ratio 1:4 was selected for further compression process. The prepared batches of ODTs were characterized for micromeritic study, thickness, hardness, weight variation, wetting time, disintegration time, drug content and in vitro drug release profile. The evaluation data for all batches was satisfactory out of them formulation TF3 containing 6% kyron T-314 showed the best results with a value of 29.3 sec and 24.1 sec for wetting and disintegration, respectively. This formulation showed superior drug release of 99.93% over a period of 30 minutes.

Formulation and In vitro Evaluation of Gastroretentive Floating Bioadhesive Tablets of Nizatidine using Factorial Design

2019 ◽  
Vol 9 (3) ◽  
pp. 234-239
Author(s):  
Vidya Sabale ◽  
Hardikkumar Chaudhari ◽  
Prafulla Sabale
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Methyl Cellulose ◽  
Lag Time ◽  
Content Uniformity ◽  
H2 Receptor Antagonist ◽  
Drug Release Profile ◽  
Drug Content ◽  
Weight Variation ◽  
Carbopol 934P

Background: The aim of the present study was to formulate and evaluate floating bioadhesive tablets of Nizatidine which is a competitive, reversible H2-receptor antagonist. Floatingbioadhesive drug delivery system exhibiting a unique combination of floatation and bioadhesion to prolong gastric residence time was prepared. Methods: Polymers used were Hydroxy Propyl Methyl Cellulose (HPMC) K15M as matrix forming water swellable release retarding polymer and carbopol 934P as bioadhesive polymer. The gas generating agents used were sodium bicarbonate and citric acid. The prepared floating bioadhesive tablets of Nizatidine were optimized by 32 factorial design to study independent variable X1 (concentration of CP 934P) and X2 (concentration of HPMC K15M) and dependent variables as floating lag time, cumulative percentage drug release at 12h and swelling index. Tablets were evaluated for various parameters such as hardness, friability, drug content, swelling behavior, floating lag time, bioadhesive strength, drug release profile and stability. Results: All the formulations passed the test for weight variation, hardness, content uniformity and showed acceptable results with respect to drug content (97.93 ± 0.57) and % friability. The tablet containing 25% HPMC K15M and 13.75 % Carbopol 934P was selected as optimized formulation which showed the floating lag time of 74.34±2.08 seconds, drug release of 97.03±0.55% at 12 h (R12h,%), S.I as 79.24±0.87 at 9 h and bioadhesive strength as 10.0023±21.47 g. Stability of the formulation was proved using stability study. Conclusion: The formulated tablets have a potential for controlled release of the drug through floatation and bioadhesion.

FORMULATION AND DEVELOPMENT OF EXTENDED RELEASE MATRIX PELLETS OF WATER INSOLUBLE AZILSARTAN MEDOXOMIL WITH SOLID DISPERSION

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (02) ◽  
pp. 21-30
Author(s):  
V. V. Pande ◽  
◽  
V. M. Sanklecha ◽  
S. R Arote
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Extended Release ◽  
Guar Gum ◽  
Drug Loading ◽  
Scanning Calorimetry ◽  
Drug Content ◽  
Rate Kinetics ◽  
Evaporation Technique ◽  
Azilsartan Medoxomil

The present study involved the design and development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion (Azil SD). A solid dispersion of azilsartan medoxomil was prepared with a carrier, Hypromallose acetate succinate (Affinisol 716G) by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD and the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology and swelling behaviourand analysis carried out using Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffraction. The solubility and dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively.The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of the Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility and dissolution of azilsartan medoxomil by using polycarbophil and HPMC K4M, forming an effective carrier for developing extended release matrix pellets.

Understanding the Impact of Polymer Ratio and its Concentration on Omeprazole Release from Matrix Tablets: Response Optimization Study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tiwari R. ◽  
Tiwari G. ◽  
Wal P. ◽  
Wal A. ◽  
Maurya P.
Keyword(s):  
Drug Release ◽  
Polymer Blend ◽  
Release Profile ◽  
Matrix Tablets ◽  
Drug Release Profile ◽  
Drug Content ◽  
Weight Variation ◽  
Carbopol 934P ◽  
Polymer Ratio

In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique using a combination of hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC) in varying ratios and the effect of polymer ratio as well as their concentration on drug release profile was investigated. Response surface methodology (RSM) was conducted to optimize matrix tablets. Compressed tablets were evaluated for hardness, friability, weight variation, drug content and in vitro dissolution studies. The dissolution study was performed in pH1.2 for the first 2 h and in phosphate buffer (pH 7.4) for another 5 h. The optimized formulation was compared with other formulations using similarity (ƒ2) and dissimilarity factor (ƒ1) test. The results of RSM indicated that both X1 (the blending ratio of HPMC K15M K15M and Carbopol 934P 934P) and X2 (polymer blend concentration)have significant effect on in-vitro drug release profile. Hardness, friability, weight variation and drug content were found to be in desired range. Among different formulations, matrix tablets prepared by HPMC K15M and Carbopol 934P 934P (7:3) with 15% polymer blend concentration displayed 98.85% OPZ release in 7 hr. and release kinetic was higuchi (r 2= 0.9884). Similarity (f2) and dissimilarity (f1) factors demonstrated that the in vitro profiles were not similar. Finally, it was concluded that release rate of OPZ decreased proportionally with increasing polymer ratio (HPMC K15M: Carbopol 934P 934P) and decreasing polymer blend concentration.

scholarly journals Formulation and Evaluation of Gastro Retentive Floating Tablets of Simvastatin using Hydrophilic Rate Retardant

2012 ◽  
Vol 15 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Md Nazmul Hussain ◽  
Md Abdullah Al Masum ◽  
Sharmin Akhter ◽  
Florida Sharmin ◽  
Md Selim Reza
Keyword(s):  
Citric Acid ◽  
Drug Release ◽  
Sodium Bicarbonate ◽  
Release Rate ◽  
Dissolution Time ◽  
Drug Release Profile ◽  
Compression Technique ◽  
Weight Variation ◽  
Gastro Retentive

Gastro retentive floating tablet of Simvastatin was prepared by direct compression technique using Methocel K4M as the rate controlling polymer. The hydrophilic cellulose derivative, Methocel K4M was evaluated for its gel forming and release controlling properties. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The effects of soluble components (sodium bicarbonate and citric acid) and gel forming agents on drug release profile and floating properties were investigated. The tablets from all formulations were evaluated for thickness, diameter, weight variation, hardness, and friability. The tablets were also tested for the buoyancy studies and in vitro drug release studies. The drug release study was evaluated for eight hours using USP XXII paddle-type dissolution apparatus using 0.1N HCl with 1% Sodium Lauryl Sulphate as dissolution medium. The release mechanisms were explored and explained with zero order, first order, Higuchi, Hixon Crowell and Korsmeyer equations. The release rate, extent and mechanisms were found to be governed by the polymer content. It was found that the mean dissolution time, percentage drug release, release rate constant and diffusion exponent were influenced significantly by the amount of polymer incorporation. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12575 Bangladesh Pharmaceutical Journal 15(2): 119-126, 2012

Formulation and Evaluation of Orally Disintegrating Tablets of Lamotrigine

2015 ◽  
Vol 8 (2) ◽  
pp. 2881-2888
Author(s):  
Sudarshan Singh ◽  
S S Shyale ◽  
P Karade
Keyword(s):  
Drug Release ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Drug Content ◽  
Weight Variation ◽  
Wetting Time ◽  
Croscarmellose Sodium

The aim of this study was to design orally disintegrating tablet (ODT) of Lamotrigine. It is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.46 mg/ml). Thus, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:1 molar ratios). The orally disintegrating tablet of lamotrigine was prepared by direct compression method using different concentration of superdisintegrants such as Sodium starch glycollate, croscarmellose sodium by sublimating agent such as camphor. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies. The prepared tablets were characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry. The disintegration time for the complexed tablets prepared by different concentration of superdisintegrants was found to be in range of 32.54 ± 0.50 to 55.12 ± 0.57 sec and wetting time of the formulations was found to be in range of 28.47 ± 0.67 to 52.19 ± 0.72 sec. All the formulation showed almost 100 percent of drug release within 15 min. Among all the formulation F6 and F7 prepared with 18% croscarmellose sodium and camphor shows faster drug release, respectively 10 min, F6 gives good result for disintegration time, drug release, wetting time and friability. Further formulations were subjected to stability testing for 30 days at temperature of 40 ± 5 ºC/75 ± 5 %RH. Tablets showed no appreciable changes with respect to physical appearance, drug content, disintegration time and dissolution profiles. Results were statistically analyzed by one-way ANOVA at a p < 0.05. It was found that, the data at any point of time are significant at p < 0.05.

scholarly journals FORMULATION AND EVALUATION OF FUROSEMIDE LIQUISOLID COMPACT

2017 ◽  
Vol 9 (6) ◽  
pp. 39
Author(s):  
Zainab E. Jassim
Keyword(s):  
Dissolution Rate ◽  
Content Uniformity ◽  
Drug Release Profile ◽  
Scanning Calorimetry ◽  
Polyethylene Glycol 400 ◽  
Coating Materials ◽  
Disintegration Time ◽  
Weight Variation ◽  
R Ratio

Objective: The purpose of this study was to enhance the dissolution pattern of the practically water-insoluble diuretic drug, furosemide through its formulation into liquisolid tablets.Methods: A mathematical model was used to formulate four liquisolid powder systems using polyethylene glycol 400 as a non-volatile water miscible liquid vehicle. The liquid loading factors of the vehicle were used to calculate the optimum quantities of carrier (Avicel PH 102) and coating materials (Aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures and (R) ratio used was 25. The liquisolid tablets were evaluated for weight variation, percent friability, hardness, content uniformity, disintegration time and in vitro drug release profile. Drug and the prepared systems were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder x-ray diffraction (PXRD) studies.Results: The enhanced dissolution rate due to the increased wetting properties and the large available surface areas for dissolution were obtained in case of the liquisolid tablets. The selected optimal formulation (F2) of 50% drug concentration released 90% of its content during the first 10 min compared to 65% of DCT. FTIR studies revealed that there was no interaction between drug and polymers. DSC and PXRD indicated conversion of crystalline to amorphous form of furosemide. Conclusion: The dissolution rate of furosemide can be enhanced to a great extent by liquisolid technique.

scholarly journals An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Mohammed Ghazwani ◽  
Umme Hani ◽  
Riyaz Ali M. Osmani ◽  
Mohamed Rahamathulla ◽  
M. Yasmin Begum ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Side Effects ◽  
Drug Release ◽  
Cancer Patients ◽  
Poloxamer 407 ◽  
Vaginal Candidiasis ◽  
Disintegration Time ◽  
Drug Content ◽  
Vaginal Suppository ◽  
Weight Variation

Aim. The study is aimed at developing curcumin suppositories as a promising approach for natural antifungal management of vaginal candidiasis in cervical cancer patients to eradicate side effects produced by current antifungal drugs. The objective of the study was to optimize the suppositories using optimal (custom) design employing Design-Expert 13 software to recognize the concentration of polyethylene glycols (PEG) and Poloxamer 407 and obtain a stable suppository. Methodology. Combinations of PEG 1500 (10%–40%), PEG 6000 (40%–60%), and Poloxamer 407 (5%–30%) were entered as factors, and the responses evaluated were hardness, deformation time, and % drug release. In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. Results. Suppositories were devoid of holes and cracks, with a characteristic odor and a dark yellowish-orange color. All formulations passed the weight variation test. Formulations exhibited pH ranging from 5.5 to 6.5. Drug content was observed to be 98.65 ± 0.041 % – 99.85 ± 0.041 % . The hardness of the formulation was between 2.9 and 4.2 kg/cm2. The disintegration time ranged from 11 ± 0.052   min to 20 ± 0.011   min . The melting point was between 41 ± 0 . 31 ° C and 58 ± 0 . 62 ° C . Deformation time ranged from 10 ± 0.45 to 35 ± 0.52   min . Most of the formulations resulted in 90% of drug release at 40 min, and the zone of inhibition noted was 19.6 ± 0.4   mm . All the selected factors have a significant effect on the response chosen for the study. Conclusion. The optimized curcumin vaginal suppository formulation can be an efficient herbal treatment devoid of side effects to treat vaginal candidiasis in cervical cancer patients.

scholarly journals Effect of Extracted Microcrystalline Cellulose from Dracaenea arborea Stem on Aceclophenac Tablet Formulation

2021 ◽  
pp. 107-117
Author(s):  
J. I. Ordu ◽  
I. E. Udenze
Keyword(s):  
Drug Release ◽  
Corn Starch ◽  
Tablet Formulation ◽  
Qualitative Assessment ◽  
Crystalline Cellulose ◽  
Burst Release ◽  
Direct Compression ◽  
Drug Release Profile ◽  
Compression Technique ◽  
Hydration Capacity

Micro crystalline cellulose (MCC) is a major derivative from the bio composite of natural materials such as D. arborea plant stem. It could be useful as a secondary binder and disintegrant in tablet formulation especially following direct compression technique anticipating it to provide high level of disintegration at low use level and utilizing dual mechanisms of wicking and swelling. Tablets of aceclofenac a BCS class II and non steroidal anti inflammatory drug (NSAID) which potently inhibits the cyclo oxygenase enzyme (COX-2) involved in prostaglandin synthesis was formulated by direct compression using MCC from D. arborea stem. Qualitative assessment of the plant extract was carried out and the presence of cellulose confirmed by the appearance of violet – blue coloration while the physicochemical and physicotechnical properties were comparatively evaluated with reference to avicel and corn starch. Three batches of aceclofenac tablets involving Batch A (D. arborea MCC), Batch B (Corn starch) and Batch C (Corn starch and D. arborea MCC in a 1:1 ratio), were implcated in the formulation. Physicochemical study of the MCC reveals a pH of 7.8, mean swelling index 1.14±0.05 ml and hydration capacity of 3.60±0.15 g while the pH of corn starch is 3.90 with swelling and hydration capacity at 5.09±0.03 ml and 8.26±0.01 g respectively. Quality control evaluation of resulting tablet was investigated and the wetting time of batch A tablets was 1.50, batch B 2.30 and batch C 1.80 with percentage moisture content (%) of 60.5, 56.56 and 57.8 and disintegration time (minutes) of 0.22±0.07, 0.35±0.051 and 1.60±0.286 respectively. The drug release profile of batch A, reveals an initial burst release within 10 minutes followed by gradual release while batch C had consistent drug release which was maintained although faster than that of batch A after 10 minutes but batch B had the least drug release rate.

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