An Overview on Medicinal Plants with Potential Antidepressant Activity

AbstractDepression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. Exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. The aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. For this purpose, electronic databases, including PubMed, Science Direct, Scopus, and Cochrane Library, were searched from 1966 to October 2013. The results showed that several molecular mechanisms could be proposed for the antidepressant activity of medicinal plants and their constituents.

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A REVIEW OF MEDICINAL PLANTS POSSESSING ANTIDEPRESSANT POTENTIAL

INDIAN DRUGS ◽

10.53879/id.53.06.10436 ◽

2016 ◽

Vol 53 (06) ◽

pp. 5-17

Author(s):

A. K. Dhingra ◽

◽

B. Chopra ◽

R Dass ◽

S. K. Mittal

Keyword(s):

Major Depression ◽

Medicinal Plants ◽

Monoamine Oxidase ◽

Serotonin Reuptake ◽

Selective Serotonin Reuptake Inhibitors ◽

Tricyclic Antidepressants ◽

Antidepressant Activity ◽

Serotonin Reuptake Inhibitors ◽

Full Remission ◽

Dopaminergic Systems

Major depression is a debilitating disorder, predicted to be the second most prevalent human malady by the year 2020. Although a variety of chemical antidepressant remedies like tricyclic antidepressants, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors are available, yet approximately 30% of depressed patients are resistant to the existing drugs and remaining 70% do not achieve full remission. Therefore, a constant urge continues for discovery of newer, better-tolerated and more efficacious treatments of depression, which include search for discovery of medicinal plants with potential antidepressant activity. The present paper discusses anti-depression potential of 70 medicinal plants with emphasis on their pre-clinical and clinical reports. Majority of plants shows antidepressant activity through serotonergic, noradrenergic and dopaminergic systems.

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A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

International Journal of Biological and Pharmaceutical Sciences Archive ◽

10.53771/ijbpsa.2021.2.1.0056 ◽

2021 ◽

Vol 2 (1) ◽

pp. 007-021

Author(s):

Ali Esmail Al-Snafi

Keyword(s):

Medicinal Plants ◽

Antidepressant Activity ◽

Mechanisms Of Action ◽

D2 Receptors ◽

D1 And D2 Receptors ◽

Normal Limits ◽

Current Review ◽

Stress Mediators ◽

Α2 Receptors ◽

Pituitary Adrenal Axis

Medicinal plants can exert antidepressant activity by many mechanisms included neutralization of various stress mediators (regulate the activity of the hypothalamic- pituitary- adrenal axis and reduce CRF, and ACTH and corticosterone) [5], interaction with serotonergic systems (5-HT3, 5HT2A, 5-HT1A), noradrenergic (α1 and α2 receptors) and dopaminergic (D1 and D2) receptors [6],restoring monoamine transmitters and their receptors to normal limits in certain regions of the cortex, in addition to reducing of oxidative stress and amelioration of inflammatory mediators. The current review discussed the antidepressant activity of medicinal plants, with emphasis on their mechanisms of action.

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