A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

Medicinal plants can exert antidepressant activity by many mechanisms included neutralization of various stress mediators (regulate the activity of the hypothalamic- pituitary- adrenal axis and reduce CRF, and ACTH and corticosterone) [5], interaction with serotonergic systems (5-HT3, 5HT2A, 5-HT1A), noradrenergic (α1 and α2 receptors) and dopaminergic (D1 and D2) receptors [6],restoring monoamine transmitters and their receptors to normal limits in certain regions of the cortex, in addition to reducing of oxidative stress and amelioration of inflammatory mediators. The current review discussed the antidepressant activity of medicinal plants, with emphasis on their mechanisms of action.

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Medicinal plants possess sedative and anxiolytic effect with emphasis on their mechanisms of action

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2021.17.3.0351 ◽

2021 ◽

Vol 17 (3) ◽

pp. 061-077

Author(s):

Ali Esmail Al-Snafi

Keyword(s):

Medicinal Plants ◽

Plant Extracts ◽

Anxiolytic Effect ◽

Mechanisms Of Action ◽

Aminobutyric Acid ◽

Na Channels ◽

Medical Problems ◽

Current Review ◽

Acid Type ◽

Web Science

Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative and anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors and chatecholamines. In the current review, Web Science, PubMed, Scopus and Science Direct, were searched to investigate the plants with sedative and anxiolytic effects

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Plant-derived natural medicines for the management of depression: an overview of mechanisms of action

Reviews in the Neurosciences ◽

10.1515/revneuro-2014-0058 ◽

2015 ◽

Vol 26 (3) ◽

Cited By ~ 35

Author(s):

Marzieh Sarbandi Farahani ◽

Roodabeh Bahramsoltani ◽

Mohammad Hosein Farzaei ◽

Mohammad Abdollahi ◽

Roja Rahimi

Keyword(s):

Medicinal Plants ◽

Psychiatric Disorder ◽

Crucial Role ◽

Molecular Mechanisms ◽

Antidepressant Activity ◽

Mechanisms Of Action ◽

Cochrane Library ◽

The World ◽

Natural Drugs ◽

Natural Medicines

AbstractDepression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. Exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. The aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. For this purpose, electronic databases, including PubMed, Science Direct, Scopus, and Cochrane Library, were searched from 1966 to October 2013. The results showed that several molecular mechanisms could be proposed for the antidepressant activity of medicinal plants and their constituents.

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Ontogeny of locomotor activity and grooming in the young rat: role of dopamine D1 and D2 receptors

European Journal of Pharmacology ◽

10.1016/0014-2999(90)90437-b ◽

1990 ◽

Vol 186 (2-3) ◽

pp. 223-230 ◽

Cited By ~ 39

Author(s):

Sanders A. McDougall ◽

Timothy F. Arnold ◽

Arthur J. Nonneman

Keyword(s):

Locomotor Activity ◽

D2 Receptors ◽

D1 And D2 Receptors ◽

Young Rat

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Effect of Zishenpingchan Granule on Neurobehavioral Manifestations and the Activity and Gene Expression of Striatal Dopamine D1 and D2 Receptors of Rats with Levodopa-Induced Dyskinesias

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/342506 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Qing Ye ◽

Xiao-Lei Yuan ◽

Jie Zhou ◽

Can-xing Yuan ◽

Xu-ming Yang

Keyword(s):

Gene Expression ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

D2 Receptors ◽

Striatal Dopamine ◽

Control Group ◽

Indirect Pathway ◽

Dopamine D2 ◽

D1 And D2 Receptors ◽

Neurobehavioral Manifestations

This study was performed to observe the effects of Zishenpingchan granule on neurobehavioral manifestations and the activity and gene expression of striatal dopamine D1 and D2 receptors of rats with levodopa-induced dyskinesias (LID). We established normal control group, LID model group, and TCM intervention group. Each group received treatment for 4 weeks. Artificial neural network (ANN) was applied to excavate the main factor influencing variation in neurobehavioral manifestations of rats with LID. The results showed that overactivation in direct pathway mediated by dopamine D1 receptor and overinhibition in indirect pathway mediated by dopamine D2 receptor may be the main mechanism of LID. TCM increased the efficacy time of LD to ameliorate LID symptoms effectively mainly by upregulating dopamine D2 receptor gene expression.

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Iron deficiency decreases dopamine D1 and D2 receptors in rat brain

Pharmacology Biochemistry and Behavior ◽

10.1016/s0091-3057(01)00563-9 ◽

2001 ◽

Vol 69 (3-4) ◽

pp. 409-418 ◽

Cited By ~ 181

Author(s):

Keith M Erikson ◽

Byron C Jones ◽

Ellen J Hess ◽

Qian Zhang ◽

John L Beard

Keyword(s):

Iron Deficiency ◽

Rat Brain ◽

D2 Receptors ◽

D1 And D2 Receptors

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Dopamine D1 or D2 antagonists enhance inhibition of consummatory ingestive behavior by CCK-8

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1995.269.4.r896 ◽

1995 ◽

Vol 269 (4) ◽

pp. R896-R903 ◽

Cited By ~ 7

Author(s):

I. Bednar ◽

H. Carrer ◽

G. A. Qureshi ◽

P. Sodersten

Keyword(s):

Inhibitory Effect ◽

D2 Receptors ◽

Skf 38393 ◽

Ingestive Behavior ◽

Male Rats ◽

Sch 39166 ◽

D1 And D2 Receptors ◽

Specific Effects ◽

Ly 171555 ◽

D2 Antagonists

A dopamine D1 (SKF-38393, 1 mg)- or D2 (LY-171555, 0.1 mg)-receptor agonist inhibited intake of an intraorally infused solution of sucrose by male rats, a test of consummatory ingestive behavior. Treatment with a D1 (SCH-39166, 0.1 mg) or D2 (raclopride, 0.6 mg) antagonist reversed inhibition by the respective agonist but enhanced the inhibitory effect of cholecystokinin octapeptide (CCK-8; 1.8 micrograms). It was not possible to demonstrate specific effects of D1 and D2 agonists on intake of pellets, a test that does not discriminate consummatory ingestive behavior from appetitive ingestive behavior, i.e., behavior used to obtain food. The results demonstrate specific involvement of dopamine D1 and D2 receptors in inhibition of consummatory ingestive behavior.

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