scholarly journals FIBRINA RICA EM PLAQUETAS (PRF) COMO TRATAMENTO DE COMUNICAÇÃO BUCO-SINUSAL: RELATO DE CASO

Author(s):  
Luiz André Da Luz Silva Alves

ResumoAs comunicações buco-sinusais são complicações pós-cirúrgicas que ocorrem mais frequentemente após exodontia de molares superiores devido a relação anatômica íntima entre o ápice das raízes desses dentes com o seio maxilar. O seu diagnóstico envolve procedimentos clínicos e radiográficos, sendo a manobra de Valsalva um passo importante do exame físico. Essas comunicações diretas entre o seio maxilar e a cavidade oral, se não tratadas de forma adequada, podem evoluir para fístulas permanentes que ocorrem quando há epitelização da mucosa. A literatura defende diferentes formas de tratamento cirúrgico, sendo a maioria através de retalhos que demandam um segundo sítio de cicatrização. Objetivando-se diminuir a morbidade desses procedimentos e a melhora da cicatrização tecidual, uma opção de tratamento é a utilização de PRF (Fibrina Rica em Plaquetas). Trata-se de uma membrana de fibrina autógena, rica em leucócitos, plaquetas e fatores de crescimento, obtida através do sangue do paciente que passa por um processo de centrifugação. O objetivo do presente trabalho é relatar um caso clínico do paciente V.A.P., leucoderma, sexo masculino, 56 anos de idade, que compareceu à Faculdade de Odontologia da Universidade Federal Fluminense, apresentando ao exame clínico e por imagem, comunicação buco - sinusal com cerca de 2,5 cm em seu maior diâmetro. Com isso, foi proposto ao paciente a ressecção da fístula e fechamento através da utilização de membranas de PRF. Após prévia utilização de antibiótico e corticoide nasal, o procedimento cirúrgico foi realizado sob anestesia local em ambiente ambulatorial, sem intercorrências e o mesmo segue em controle pós-operatório com cerca de 2 meses, com boa evolução e sem sintomatologia.Palavras-chave: seio maxilar, comunicação buco-sinusal, fibrina rica em plaquetas.AbstractBuco-sinus communications are postoperative complications that occur most frequently after maxillary molar extraction due to the close anatomical relationship between the apex of the roots of these teeth and the maxillary sinus. Its diagnosis involves clinical and radiographic procedures, and the Valsalva maneuver is an important step of the physical examination. These direct communications between the maxillary sinus and the oral cavity, if not properly treated, can progress to permanent fistulas that occur when mucosal epithelialization occurs. The literature defends different forms of surgical treatment, most of them through flaps that require a second healing site. In order to reduce the morbidity of these procedures and improve tissue healing, one treatment option is the use of PRF (Fibrin Rich Platelet). It is an autogenous fibrin membrane, rich in leukocytes, platelets and growth factors that is obtained through the patient's blood that goes through a centrifugation process. The aim of the present study is to report a clinical case of VAP patient, leucoderma, male, 56 years old, who attended the Fluminense Federal University Dental School, presenting oral and sinus communication with 2.5 cm at its largest diameter. Thus, the patient was proposed for resection of the fistula and closure through the use of PRF membranes. After previous use of antibiotics and nasal corticosteroids, the surgical procedure was performed under local anesthesia in an outpatient setting, uneventful and the same follows in postoperative control for 2 months, with good evolution and without symptoms.Keywords: maxillary sinus, oral-sinus communication, platelet-rich fibrin.

Author(s):  
Pâmella Santana Nunes

ResumoO Granuloma Piogênico é descrito como um aumento de volume não neoplásico, de crescimento acelerado e indolorque ocorre em resposta reacional a irritantes locais ou traumáticos, com frequentes recidivas.Apresenta-se como uma lesãode superfície lisa ou lobulada, base normalmente pediculada, intensa vascularização e predileção pela gengiva. A fim de minimizar o defeito cirúrgico e melhorar o processo de cicatrização, a utilização de Fibrina Rica em Plaquetas (PRF) para recobrimento local após a exérese da lesão é uma alternativa favorável ao prognóstico do tratamento. Trata-se de uma membrana de fibrina autógena, rica em leucócitos, plaquetas e fatores de crescimento, obtida através do sangue do paciente que passa por um processo de centrifugação.O objetivo do presente trabalho érelatarum caso clínico da paciente C.S.G.T, leucoderma, sexo feminino, 50 anos de idade, que compareceu à Faculdade de Odontologia da Universidade Federal Fluminense, com um quadro clínico de Granuloma Piogênico recidivante tratadocom exérese da lesão e PRF. O procedimento cirúrgico foi realizado sob anestesia local em ambiente ambulatorial, sem intercorrências e segue em controle pós-operatório com cerca de 2 meses, com boa evolução.Palavras-chave:granuloma piogênico; fibrina rica em plaquetas; regeneração tecidualAbstractPyogenic Granuloma is described as a painless, fast-growing, non-neoplastic swelling that occurs in reaction to local or traumatic irritants, with frequent relapses. It presents as a lesion with a smooth or lobulated surface, usually pediculated base, intense vascularization and predilection for the gum. In order to minimize the surgical defect and improve the healing process, the use of Platelet Rich Fibrin (PRF) for local coverage after lesion excision is a favorable alternative to treatment prognosis. It is an autogenous fibrin membrane, rich in leukocytes, platelets and growth factors, obtained through the patient's blood that goes through a centrifugation process. The objective of the present study is to report a clinical case of a 50-year-old female patient, CSGT, leucoderma, who attended the Fluminense Federal UniversityDentistry School, with a clinical picture of recurrent pyogenic granuloma treated with excision and PRF. The surgical procedure was performed under local anesthesia in an outpatient setting, uneventful and the same follows in postoperative control with about 2 months, with good evolution.Keywords: pyogenic granuloma; platelet-rich fibrin; tissue regeneration


Author(s):  
Pâmella Santana Nunes

ResumoO Granuloma Piogênico é descrito como um aumento de volume não neoplásico, de crescimento acelerado e indolor que ocorre em resposta reacional a irritantes locais ou traumáticos, com frequentes recidivas. Apresenta-se como uma lesão de superfície lisa ou lobulada, base normalmente pediculada, intensa vascularização e predileção pela gengiva. A fim de minimizar o defeito cirúrgico e melhorar o processo de cicatrização, a utilização de Fibrina Rica em Plaquetas (PRF) para recobrimento local após a exérese da lesão é uma alternativa favorável ao prognóstico do tratamento. Trata-se de uma membrana de fibrina autógena, rica em leucócitos, plaquetas e fatores de crescimento, obtida através do sangue do paciente que passa por um processo de centrifugação. O objetivo do presente trabalho é relatar um caso clínico da paciente C.S.G.T, leucoderma, sexo feminino, 50 anos de idade, que compareceu à Faculdade de Odontologia da Universidade Federal Fluminense, com um quadro clínico de Granuloma Piogênico recidivante tratado com exérese da lesão e PRF. O procedimento cirúrgico foi realizado sob anestesia local em ambiente ambulatorial, sem intercorrências e o mesmo segue em controle pós-operatório com cerca de 2 meses, com boa evolução.Palavras-chave: granuloma piogênico; fibrina rica em plaquetas; regeneração tecidualAbstractPyogenic Granuloma is described as a painless, fast-growing, non-neoplastic swelling that occurs in reaction to local or traumatic irritants, with frequent relapses. It presents as a lesion with a smooth or lobulated surface, usually pediculated base, intense vascularization and predilection for the gum. In order to minimize the surgical defect and improve the healing process, the use of Platelet Rich Fibrin (PRF) for local coverage after lesion excision is a favorable alternative to treatment prognosis. It is an autogenous fibrin membrane, rich in leukocytes, platelets and growth factors, obtained through the patient's blood that goes through a centrifugation process. The objective of the present study is to report a clinical case of a 50-year-old female patient, CSGT, leucoderma, who attended the Fluminense Federal University Dentistry School, with a clinical picture of recurrent pyogenic granuloma treated with excision and PRF. The surgical procedure was performed under local anesthesia in an outpatient setting, uneventful and the same follows in postoperative control with about 2 months, with good evolution.Keywords: pyogenic granuloma; platelet-rich fibrin; tissue regeneration


Author(s):  
Liangjing Xin ◽  
Shuai Yuan ◽  
Zhixiang Mu ◽  
Dize Li ◽  
Jinlin Song ◽  
...  

BackgroundSchneiderian membrane (SM) perforation is a major complication of maxillary sinus elevation with simultaneous bone grafting, yet under this scenario there is no standard biomaterial that maximizes favorable tissue healing and osteogenic effects.PurposeTo compare the effect of advanced platelet-rich fibrin (A-PRF) and collagen membrane (CM) on a perforated SM with simultaneous bone grafting in a maxillary sinus elevation model.Materials and MethodsAfter perforation of the SM was established, 24 animals were randomly divided into two groups: (i) group CM: CM and deproteinized bovine bone mineral (DBBM) (n = 12), (ii) group A-PRF: A-PRF and DBBM (n = 12). Radiographic and histological evaluations were performed at 1 and 4 weeks post-operation.ResultsAt 1 week, an intact SM was found in group A-PRF. At each time point, the number of inflammatory cells at the perforated site was higher in group CM, and the area of new osteoid formation was significantly greater in group A-PRF (p < 0.0001). At 4 weeks, the osteogenic pattern was shown as from the periphery to the center of the sinus cavity in group A-PRF.ConclusionThe higher elasticity, matching degradability, and plentiful growth factors of A-PRF resulted in a fully repaired SM, which later ensured the two osteogenic sources from the SM to generate significant new bone formation. Thus, A-PRF can be considered to be a useful bioactive tissue-healing biomaterial for SM perforation with simultaneous bone grafting.


2021 ◽  
Vol 11 (8) ◽  
pp. 3365
Author(s):  
Benjie Law ◽  
Hui Yuh Soh ◽  
Syed Nabil ◽  
Rama Krsna Rajandram ◽  
Abd Jabar Nazimi ◽  
...  

Osteoradionecrosis (ORN) of the jaws and medication-related osteonecrosis of the jaws (MRONJ) are uncommon but serious diseases affecting the oral and maxillofacial region with clinically similar appearance but distinct pathophysiology. Management of ORN and MRONJ is inherently challenging and the treatment outcomes are unpredictable. The use of autologous platelet concentrates (APCs) to promote hard and soft tissue healing is well described in the literature, and the efficacy of leucocyte and platelet-rich fibrin (L-PRF) has been well documented in a number of clinical studies. The aim of this study was to present our treatment strategy and the outcomes of incorporating L-PRF as a surgical adjunct in management of ORN and MRONJ in our centre. Methods: eight cases of ORN and MRONJ were treated with a combination of sequestrectomy and L-PRF as a surgical adjunct. Results: the overall success was 87.5%. Using L-PRF as an adjunct, we were able to predictably manage ORN and MRONJ without causing significant morbidity. Conclusion: our experience shows that L-PRF may be used as a valuable and cost-effective adjunct to surgical management of ORN and MRONJ. However, due to a limited number of patients, and a short period of review, the true effectiveness of the method is yet to be demonstrated in a longer follow-up study including a greater number of patients, besides the inclusion of a control group.


Author(s):  
Esraa Ahmed Eid ◽  
Fatma Mostafa El-Badawy ◽  
Walaa Mohamed Hamed

Abstract Background The proximity of the maxillary sinus floor to the maxillary molar roots increases the probability of oroantral communication on conducting any surgical or endodontic procedure in the involved area. The aim of this study is to evaluate the relationship between each maxillary molar root and maxillary sinus floor using cone beam computed tomography. Predicting the probability of protrusion of each root into the sinus will consequently predict the probability of occurrence of the oroantral fistula in a sample of the Egyptian population. Results The total number of roots located outside the sinus was 121 (35.3%), while those contacting the sinus floor were 80 (23.3%) and those intruded the sinus were 141 (41.2%). The percentage of root intrusion into the sinus in males (56.9%) was significantly (p = 0.01) higher than females (42.9%). The probability of root intrusion in the left molars (54.2%) was non-significantly (p = 0.067) higher than that of the right side (44.3%). As for the type of tooth, the second molar showed the highest probability of root intrusion into the sinus (55.3%) followed by the third molars (52.6%) then the first molars (40.9). According to the type of root, the mesiobuccal root showed the highest probability of intrusion into the sinus (50.9%) followed by the palatal root (49.1%) then the distobuccal root (47.4%). However, the difference in both type of tooth and type of root was statistically non-significant (p = 0.051 and 0.869 respectively). As for the individual root with the highest probability of intrusion, the mesio-buccal root of the right third molar is the most frequent root to intrude the sinus (71.4%) and the mesio-buccal root of the right first molar is the least frequent (22.7%). Conclusions In a sample of the Egyptian population, males exhibit higher probability of root protrusion into the sinus than females. The side and type of tooth are of higher impact on the probability of its intrusion into the sinus compared to the type of root. Left second molars are at a higher risk of oroantral communications on surgical or endodontic procedures compared to other molars due to its highest probability of intrusion into the sinus.


2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
Joshua Burke ◽  
Jack Helliwell ◽  
Mikolaj Kowal ◽  
David Jayne

Abstract Aim Platelet-rich fibrin (PRF) is a three-dimensional fibrin scaffold with associated platelets and leukocytes which releases high quantities of growth factors over a sustained period of time. PRF has shown promising clinical results in promoting wound healing and tissue regeneration. The aims of this feasibility study were to establish optimal spinning methods for production of PRF, to quantify the production of vascular endothelial growth factor (VEGF) by PRF and to explore new vehicles of clinical PRF delivery. Method Assessment of optimal production involved comparisons between Protocol 1 (EDTA bottle) and Protocol 2 (no additive) at three different centrifugation forces: 400g, 1000g and 1700g. VEGF production was analysed using ELISA with varied incubation periods and PRF plug segments. Novel methods for PRF delivery were explored using surgical sutures and a Zimmer® Skin Graft Mesher. Results Protocol 2 demonstrated shorter average time to blood draw (9.8s compared to 13.6s) and to centrifuge (25.5s compared to 33.1s) with a decreased range of values. All PRF segments exhibited a positive correlation between incubation time and amount of VEGF produced with the bottom segments producing on average more VEGF. A segment of the fibrin plug was successfully secured on a suture and meshed in a 1:1.5 ratio. Conclusions PRF production can be optimised using blood bottles with no additive and high centrifugation forces. VEGF production by PRF peaks at 120 hours with the bottom PRF segment exhibiting the highest rate of production. The first description of a PRF mesh enables new clinical applications.


2015 ◽  
Vol 42 (6) ◽  
pp. 421-423 ◽  
Author(s):  
Carlos Fernando de Almeida Barros Mourão ◽  
Helder Valiense ◽  
Elias Rodrigues Melo ◽  
Natália Belmock Mascarenhas Freitas Mourão ◽  
Mônica Diuana-Calasans Maia

The use of autologous platelet concentrates, represent a promising and innovator tools in the medicine and dentistry today. The goal is to accelerate hard and soft tissue healing. Among them, the platelet-rich plasma (PRP) is the main alternative for use in liquid form (injectable). These injectable form ofplatelet concentrates are often used in regenerative procedures and demonstrate good results. The aim of this study is to present an alternative to these platelet concentrates using the platelet-rich fibrin in liquid form (injectable) and its use with particulated bone graft materials in the polymerized form.


2017 ◽  
Vol 137 (7) ◽  
pp. 695-699 ◽  
Author(s):  
Nuray Ensari ◽  
Özer Erdem Gür ◽  
Mehmet Türker Öztürk ◽  
Dinç Süren ◽  
Ömer Tarık Selçuk ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document