Antibacterial Activity of Medicinal Plants Used in the Management of HIV/AIDs Opportunistic Infections in Njeru Sub County, Buikwe District

HIV / AIDS infection is characterized by the reduction of the body's defenses favoring the occurrence "opportunistic" infections, as bronchitis, mycoses and tuberculosis etc. Thus, to fight against this virus, antiretrovirals are used. The Ziguinchor district (Senegal) has a higher seroprevalence rate of 2.2% above the national average of 0.7%. It is in this sense that a survey of two herbalists, 35 tradipraticians and eight resource persons was conducted to identify the plants used in the management of opportunistic AIDS diseases because as the populations often resort to phytotherapy. 88 plants were identified and divided into 79 genera and 38 families. Some species were mentioned very more frequently and in many diseases. These are: Cordila pinnata Poir. (78%), Guiera senegalensis (73.1%), Khaya senegalensis (67%), Icacina oliviformis (55%), Terminalia macroptera (55%), Cassia sieberiana (47%), etc. Leaves and roots constituted the greatest use in the form of macerated, infused, for drinking, bathing, or fumigation, etc. The expected result during this study was the establishment of a repertory of medicinal plants used for the management of opportunistic diseases.

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Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Papua New Guinea

Planta Medica ◽

10.1055/s-0035-1556100 ◽

2015 ◽

Vol 81 (11) ◽

Author(s):

PP Rai ◽

T Matainaho ◽

LR Barrows

Keyword(s):

Medicinal Plants ◽

Traditional Medicine ◽

Papua New Guinea ◽

New Guinea ◽

Hiv Aids

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EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF SOME MEDICINAL PLANTS EXTRACT AGAINST SOME HUMAN PATHOGENIC BACTERIA

Pakistan Journal of Biotechnology ◽

10.34016/pjbt.2020.17.1.2 ◽

2020 ◽

Vol 17 (1) ◽

pp. 9-15

Author(s):

Anees Ahmad ◽

Sayed Abdullah

Keyword(s):

Antibacterial Activity ◽

Medicinal Plants ◽

Pathogenic Bacteria ◽

Human Pathogenic Bacteria ◽

Plants Extract

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Biochemical Composition, Antibacterial and Anti-Biofilm Activities of Indian Medicinal Plants

Anti-Infective Agents ◽

10.2174/2211352518999200622152308 ◽

2020 ◽

Vol 18 ◽

Author(s):

Mulugeta Mulat ◽

Fazlurrahman Khan ◽

Archana Pandita

Keyword(s):

Antibacterial Activity ◽

Medicinal Plants ◽

Pathogenic Bacteria ◽

Chemical Constituents ◽

Multidrug Resistant ◽

Chloroform Extract ◽

Acetone Extract ◽

Biologically Active ◽

Ocimum Sanctum ◽

Agar Disc

Background: Medicinal plants have been used for treatments of various health ailments and the practices as a remedial back to thousands of years. Currently, plant-derived compounds used as alternative ways of treatment for multidrug-resistant pathogens. Objective: In the present study, various parts of six medical plants such as Solanum nigrum, Azadirachta indica, Vitex negundo, Mentha arvensis, Gloriosa superba, and Ocimum sanctum were extracted for obtaining biological active constituents. Methods: Soxhlet method of extraction was used for obtaining crude extracts. Agar disc diffusion and 96-well plate spectroscopic reading were used to detect the extract’s antibacterial and antibiofilm properties. Results: The obtained extracts were tested for antimicrobial and antibiofilm properties at 25 mg/mL concentrations. Maximum antibacterial activity was observed in O. sanctum chloroform extract (TUCE) against Staphylococcus aureus (24.33±1.52 mm), S. nigrum acetone extract (MAAC) against Salmonella Typhimurium (12.6 ± 1.5 mm) and Pseudomonas aeruginosa (15.0 ±2.0 mm). Only TUCE exhibited antibacterial activity at least a minimum inhibitory concentration of 0.781 mg/mL. Better antibiofilm activities were also exhibited by petroleum extracts of G. superba (KAPE) and S. nigrum (MAPE) against Escherichia coli, S. Typhimurium, P. aeruginosa and S. aureus. Moreover, S. nigrum acetone extract (MAAC) and O. sanctum chloroform extract (TUCE) were showed anti-swarming activity with a reduction of motility 56.3% against P. aeruginosa and 37.2% against S. aureus. MAAC also inhibits Las A activity (63.3% reduction) in P. aeruginosa. Conclusion: Extracts of TUCE, MAAC, MAPE, and KAPE were exhibited antibacterial and antibiofilm properties against the Gram-positive and Gram-negative pathogenic bacteria. GCMS identified chemical constituents are responsible for being biologically active.

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Dukungan sosial dan kualitas hidup orang dengan HIV/AIDS

Berita Kedokteran Masyarakat ◽

10.22146/bkm.12563 ◽

2017 ◽

Vol 33 (3) ◽

pp. 147

Author(s):

Mardia Mardia ◽

Riris Andono Ahmad ◽

Bambang Sigit Riyanto

Keyword(s):

Quality Of Life ◽

Social Support ◽

Antiretroviral Therapy ◽

Social Life ◽

Opportunistic Infections ◽

People Living With Hiv ◽

Hiv Diagnosis ◽

Criteria For Diagnosis ◽

Hiv Aids

Purpose: This study aimed to determine the quality of life among people living with HIV/AIDS based on the criteria for diagnosis and other factors.Methods: This study was conducted in the VCT clinic hospital of Dr. Moewardi. The population was HIV-positive patients with antiretroviral therapy. Data collection conducted through medical records and interview to patients. Results: Out of a total of 89 respondents, 66.29% were males and 71.91% were aged between 26-45 years. We found significant correlations for diagnosis of HIV/AIDS, opportunistic infections, time since HIV diagnosis, duration of ARV therapy, social support, modes of transport, sex, age, and marital status with the quality of life. Multivariate analysis obtained by each variable showed the strongest association with the quality of life was time since diagnosis, social support and duration of ARV therapy. Conclusion: The quality of life was better for those who have been diagnosed with HIV/AIDS ≥ 32 months, with social support, and who have been undergoing antiretroviral therapy ≥ 29 months. Improved counseling in the early days of ARV therapy is necessary to always maintain the treatment and provide support for their social life.

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Antibacterial, antioxidant, and sun protection potential of selected ethno medicinal plants used for skin infections in Uganda

Tropical Medicine and Health ◽

10.1186/s41182-021-00342-y ◽

2021 ◽

Vol 49 (1) ◽

Author(s):

Jane Namukobe ◽

Peter Sekandi ◽

Robert Byamukama ◽

Moses Murungi ◽

Jennifer Nambooze ◽

...

Keyword(s):

Antibacterial Activity ◽

Medicinal Plants ◽

Inhibitory Concentration ◽

Antioxidant Properties ◽

Sun Protection ◽

Albino Rats ◽

Skin Infections ◽

Double Beam ◽

Protection Potential ◽

Bacterial Skin Infections

Abstract Background Rural populations in Uganda rely heavily on medicinal plants for the treatment of bacterial skin infections. However, the efficacy of these medicinal plants for their pharmacological action is not known. The study aimed at evaluating the antibacterial, antioxidant, and sun protection potential of Spermacoce princeae, Psorospermum febrifugum, Plectranthus caespitosus, and Erlangea tomentosa extracts. Methods The plant samples were extracted by maceration sequentially using hexane, dichloromethane, ethyl acetate, methanol, and distilled water. Antibacterial activity of each extract was carried out using an agar well diffusion assay against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonie, Streptococcus pyogenes, and Salmonella typhi. Acute dermal toxicity of the aqueous extract of S. princeae and P. febrifugum, and E. tomentosa was assessed in young adult healthy Wistar albino rats at a dose of 8000 and 10,000 mg/kg body weight. The antioxidant activity of each extract was carried out using a 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The sun protection factor was determined using Shimadzu UltraViolet-Visible double beam spectrophotometer between 290 and 320 nm. Results The plant extracts showed good antibacterial activity against the tested bacterial strains with minimum inhibitory concentration (MIC) ranging between 3.12 and 12.5 mg/ml. There was no significant change in the levels of creatinine, alanine aminotransferase, and aspartate aminotransferase in the rats even at a higher dose of 10,000 mg/kg, which was related to the results of biochemical analysis of the blood samples from the treated and control groups. The aqueous and methanol extracts of S. princeae showed potential antioxidant properties, with half maximal inhibitory concentration (IC50) values of 59.82 and 61.20 μg/ml respectively. The organic and aqueous extracts of P. caespitosus showed high levels of protection against Ultraviolet light with sun protection potential values ranging between 30.67 and 37.84. Conclusions The study demonstrated that the selected medicinal plants possessed good antibacterial, antioxidant, and sun protection properties. Therefore, the plants are alternative sources of antibacterial, antioxidant, and sun protection agents in managing bacterial skin infections.

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