scholarly journals Assessment of serum vitamin D level and its relationship with disease activity in adult patients with Systemic Lupus Erythematosus (SLE)

2020 ◽  
Vol 5 (2) ◽  
pp. 73-80
Author(s):  
Zahra Bagheri-Hosseinabadi ◽  
Fatemeh Moadab ◽  
Zahra Kamiab ◽  
Amir Rahnama ◽  
Mitra Abbasifard
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Adult Patients ◽  
Systemic Lupus ◽  
Serum Vitamin D

scholarly journals Serum vitamin D/25(OH)D associated with toll-like receptor (TLR) 2 expression of immune cells in the saliva of Systemic Lupus Erythematosus: a preliminary study

2021 ◽  
Vol 27 (2) ◽  
pp. 22
Author(s):  
Hendri Susanto ◽  
Bagus Soebadi ◽  
Diah Savitri Ernawati ◽  
Adiastuti Endah Pamardiati ◽  
Hening Tuti Hendarti ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Immune Cells ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Tlr2 Expression ◽  
Cross Sectional ◽  
Serum Vitamin D

Objective: Vitamin D deficiency may contribute to Systemic Lupus Erythematosus (SLE) development. Vitamin D may involve in pathogen recognition through Toll-like receptor (TLR) 2 in immune cells in saliva. This study aimed to determine the correlation between serum vitamin D/25(OH)D and TLR2 expression of immune cells in the saliva of SLE. Materials and methods: This cross-sectional study conducted at the the SLE patients who met the inclusion and exclusion criteria. Those who had signed informed consent involved to underwent unstimulated saliva collection and blood samples for TLR2 and vitamin D/25(OH)D examination. The correlation between serum vitamin D/25(OH)D concentration and salivary TLR2 expression was analyzed using the correlation test, linear regression with 95% confidence level. Results: Thirty SLE patients had a mean serum vitamin D/25(OH)D concentration of 9.98 ± 4.64 ng/ml. The mean of TLR2 expression of CD11b+ cells in saliva was 26.03 ± 20.92%. There was a significant positive correlation between serum vitamin D/25(OH)D concentration and TLR 2 expression of CD11b+ cells in the saliva. (r = 0.434; P < 0.05). Vitamin D/25(OH)D was the only predictor for TLR 2 expression. Conclusion: Serum vitamin D/25(OH)D concentrations associated with TLR2 expression of CD11b+ cells in the saliva of SLE.

scholarly journals Assessment of serum vitamin D level in patients with systemic lupus erythematosus

2014 ◽  
Vol 41 (2) ◽  
pp. 71 ◽  
Author(s):  
TaghreedM Abd El-Wahab ◽  
SabahI Abdel Rahem ◽  
AmalS. Elsalhy ◽  
FahmiE. Emam ◽  
MahaS. Mohammed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Systemic Lupus ◽  
Serum Vitamin D

Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?: Table 1

2010 ◽  
Vol 69 (6) ◽  
pp. 1155-1157 ◽  
Author(s):  
H Amital ◽  
Z Szekanecz ◽  
G Szücs ◽  
K Dankó ◽  
E Nagy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Serum Concentrations ◽  
Systemic Lupus ◽  
Serum Vitamin D ◽  
Z Scores ◽  
25 Oh Vitamin D ◽  
Low Serum

BackgroundLow serum vitamin D concentrations have been reported in several autoimmune disorders.ObjectiveTo assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE).Methods378 patients from several European and Israeli cohorts were pooled and their disease activity was measured by two different methods: 278 patients had SLE disease activity-2000 (SLEDAI-2K) scores and 100 patients had European Consensus Lupus Activity Measurement (ECLAM) scores. In order to combine the two systems the scores were converted into standardised values (z-scores), enabling univariate summary statistics for the two variables (SLEDAI-2K and ECLAM). The commercial kit, LIAISON 25-OH vitamin D assay (310900-Diasorin) was used to measure serum concentration of 25-OH vitamin D in 378 patients with SLE.ResultsA significant negative correlation was demonstrated between the serum concentration of vitamin D and the standardised values (z-scores) of disease activity scores as measured by the SLEDAI-2K and ECLAM scales (Pearson's correlation coefficient r=−0.12, p=0.018).ConclusionsIn a cohort of patients with SLE originating from Israel and Europe vitamin D serum concentrations were found to be inversely related to disease activity.

scholarly journals Seluang Fish (Rasbora Spp.) Oil Decreases Inflammatory Cytokines Via Increasing Vitamin D Level in Systemic Lupus Erythematosus

2019 ◽  
Vol 7 (9) ◽  
pp. 1418-1421 ◽  
Author(s):  
Radiyati Umi Partan ◽  
Rachmat Hidayat ◽  
Nurwan Saputra ◽  
Febry Rahmayani ◽  
Hari Prapto ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Fish Oil ◽  
Inflammatory Cytokines ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Therapeutic Modality ◽  
Systemic Lupus ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BACKGROUND: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder mediated by inflammatory cytokines. Decreasing vitamin D levels is a common feature in SLE patients. Vitamin D has the capacity in suppressing inflammatory cascade. Seluang fish (Rasbora spp.) contained a high level of vitamin D with the potential as a new therapeutic modality. AIM: This study aimed to assess the efficacy of Seluang fish oil against proinflammatory cytokines, vitamin D levels, and clinical conditions of SLE. METHODS: A randomised, double-blind, clinical trial study design was conducted. The subjects were 16 SLE subjects treated with 500uL Seluang fish oil capsules and 16 SLE subjects with placebo capsules. Measurement of vitamin D, IL-1, IL-6 and IL-17 levels were performed with ELISA. Clinical assessment of SLE was performed with MEX-SLEDAI. Bivariate analysis, T-test, was performed. Data were presented in the form of mean ± SD. RESULTS: The administration of Seluang fish oil was clinically able to show efficacy assessed by the MEX SLEDAI score. Significant results were also shown by increased vitamin D levels and reduced levels of IL-1, IL-6 and IL-17, in Seluang fish oil group. CONCLUSION: Seluang fish oil possessed the efficacy of reducing the inflammatory response in SLE patients by increasing serum vitamin D levels.

scholarly journals Effect of Vitamin D Supplementation in Disease Activity, Activity-Related Markers, Inflammatory Marker and Serum Calcium of Systemic Lupus Erythematosus Patiens: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 13 (1) ◽  
pp. 504-515
Author(s):  
G Kambayana ◽  
Dwijo Anargha Sindhughosa ◽  
Pande Ketut Kurniari ◽  
Wira Gotera ◽  
Yenny Kandarini
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Serum Calcium ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Systemic Lupus ◽  
Serum Vitamin D ◽  
Effect Model

Background: Effect of additional supplementation of vitamin D toward Systemic lupus erythematosus (SLE) disease activity still differ in results obtained between studies being conducted. The current meta-analysis systematically analyzed the effect of vitamin D supplementation on SLE disease activity with updated literature, also its effect toward other parameters. Material and Methods: Relevant literatures were obtained from PubMed database and Google Scholar. The obtained studies were analyzed using fixed effect model or random effect model. Results: Five eligible studies with a total of 318 participants were included. Vitamin D supplementation did not affect the total SLEDAI score in SLE patients with pooled mean difference of -0.96 (p =0.09; 95% CI: -2.06 to 0.14). Serum vitamin D level increased after administration of vitamin D with pooled mean difference of 12.67 (p =0.001; 95% CI: 5.04 to 20.29). vitamin D supplementation increase serum calcium levels, with pooled difference of 0.07 (p = 0.006; 95% CI: 0.02 to 0.12). Pooled results from two studies obtained vitamin D supplementation did not affect ESR, C3 and C4. Conclusions: Current meta-analysis obtained no significant changes in SLEDAI scores due to vitamin D supplementation. In contrast, serum vitamin D and serum calcium levels were increased.

scholarly journals Effect of vitamin D supplementation on disease activity (SLEDAI) and fatigue in Systemic Lupus Erythematosus patients with hipovitamin D: An Open Clinical Trial

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Achmad Rifa’i ◽  
Handono Kalim ◽  
Kusworini Kusworini ◽  
Cesarius Singgih Wahono
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Trial ◽  
Vitamin D ◽  
Placebo Group ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Systemic Lupus ◽  
Significant Difference

Background : Low level of vitamin D impact the disease activity and the degree of fatigue in SLE patients. This study aims to determine the effect of vitamin D supplementation on disease activity and fatigue condition in Systemic Lupus Erythematosus (SLE) patients with hipovitamin D.Methods: We performed an open clinical trial. Subjects were randomized into two different groups (supplementation or placebo) using simple random sampling. The treatment group got vitamin D3 softgel/ cholecalciferol 1200 IU/day or 30 mg/day, while the control group gotplacebo for 3 months. SLEDAI scores and FSS scores were calculated at pre and posttreatment.Results: There were 20 subjectsfor supplementation group and 19 subjects in the placebo group. From this study, before and after treatment, we found a significant difference of mean level of vitamin D in supplementation group (p=0.000), and no significant difference inpatients with placebo (p=0.427). Moreover, from the SLEDAI score analysis, observed a significant difference bothin the supplemented group (p=0.000) and the placebo group (p=0.006). FSS scores significantly different in the supplemented group (p=0.000). Incorrelation test,there was a negative correlation (r=-0763) between vitamin D level and disease activity (SLEDAI), and both showing stastistical significance between thepre supplementation (p=0.000) and post supplementation (r=-0846; p=0.000). Similarly to theFSS scores, there was a meaningfulnegative correlation (r=-0.931, p=0.000) between the level of vitamin D with FSS scores pre and post supplementation (r=-0.911; p= 0.000). Furthermore, there was a significant correlation between disease activity (SLEDAI) pre supplementation with fatigue condition pre supplementation (r=0.846; p = 0.000) and postsupplementation (r=0.913; p= 0.000).Conclusion: The supplementation of vitamin D 1200 IU per day in patients with SLE improve disease activity and degree of fatigue. Keywords: vitamin D, disease activity, fatigue, SLE

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