scholarly journals Seluang Fish (Rasbora Spp.) Oil Decreases Inflammatory Cytokines Via Increasing Vitamin D Level in Systemic Lupus Erythematosus

2019 ◽  
Vol 7 (9) ◽  
pp. 1418-1421 ◽  
Author(s):  
Radiyati Umi Partan ◽  
Rachmat Hidayat ◽  
Nurwan Saputra ◽  
Febry Rahmayani ◽  
Hari Prapto ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Fish Oil ◽  
Inflammatory Cytokines ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Therapeutic Modality ◽  
Systemic Lupus ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BACKGROUND: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder mediated by inflammatory cytokines. Decreasing vitamin D levels is a common feature in SLE patients. Vitamin D has the capacity in suppressing inflammatory cascade. Seluang fish (Rasbora spp.) contained a high level of vitamin D with the potential as a new therapeutic modality. AIM: This study aimed to assess the efficacy of Seluang fish oil against proinflammatory cytokines, vitamin D levels, and clinical conditions of SLE. METHODS: A randomised, double-blind, clinical trial study design was conducted. The subjects were 16 SLE subjects treated with 500uL Seluang fish oil capsules and 16 SLE subjects with placebo capsules. Measurement of vitamin D, IL-1, IL-6 and IL-17 levels were performed with ELISA. Clinical assessment of SLE was performed with MEX-SLEDAI. Bivariate analysis, T-test, was performed. Data were presented in the form of mean ± SD. RESULTS: The administration of Seluang fish oil was clinically able to show efficacy assessed by the MEX SLEDAI score. Significant results were also shown by increased vitamin D levels and reduced levels of IL-1, IL-6 and IL-17, in Seluang fish oil group. CONCLUSION: Seluang fish oil possessed the efficacy of reducing the inflammatory response in SLE patients by increasing serum vitamin D levels.

scholarly journals Serum vitamin D/25(OH)D associated with toll-like receptor (TLR) 2 expression of immune cells in the saliva of Systemic Lupus Erythematosus: a preliminary study

2021 ◽  
Vol 27 (2) ◽  
pp. 22
Author(s):  
Hendri Susanto ◽  
Bagus Soebadi ◽  
Diah Savitri Ernawati ◽  
Adiastuti Endah Pamardiati ◽  
Hening Tuti Hendarti ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Immune Cells ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Tlr2 Expression ◽  
Cross Sectional ◽  
Serum Vitamin D

Objective: Vitamin D deficiency may contribute to Systemic Lupus Erythematosus (SLE) development. Vitamin D may involve in pathogen recognition through Toll-like receptor (TLR) 2 in immune cells in saliva. This study aimed to determine the correlation between serum vitamin D/25(OH)D and TLR2 expression of immune cells in the saliva of SLE. Materials and methods: This cross-sectional study conducted at the the SLE patients who met the inclusion and exclusion criteria. Those who had signed informed consent involved to underwent unstimulated saliva collection and blood samples for TLR2 and vitamin D/25(OH)D examination. The correlation between serum vitamin D/25(OH)D concentration and salivary TLR2 expression was analyzed using the correlation test, linear regression with 95% confidence level. Results: Thirty SLE patients had a mean serum vitamin D/25(OH)D concentration of 9.98 ± 4.64 ng/ml. The mean of TLR2 expression of CD11b+ cells in saliva was 26.03 ± 20.92%. There was a significant positive correlation between serum vitamin D/25(OH)D concentration and TLR 2 expression of CD11b+ cells in the saliva. (r = 0.434; P < 0.05). Vitamin D/25(OH)D was the only predictor for TLR 2 expression. Conclusion: Serum vitamin D/25(OH)D concentrations associated with TLR2 expression of CD11b+ cells in the saliva of SLE.

scholarly journals Assessment of serum vitamin D level in patients with systemic lupus erythematosus

2014 ◽  
Vol 41 (2) ◽  
pp. 71 ◽  
Author(s):  
TaghreedM Abd El-Wahab ◽  
SabahI Abdel Rahem ◽  
AmalS. Elsalhy ◽  
FahmiE. Emam ◽  
MahaS. Mohammed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Systemic Lupus ◽  
Serum Vitamin D

scholarly journals Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus

Lupus ◽  
2017 ◽  
Vol 26 (14) ◽  
pp. 1517-1527 ◽  
Author(s):  
R Willis ◽  
M Smikle ◽  
K DeCeulaer ◽  
Z Romay-Penabad ◽  
E Papalardo ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Disease Activity ◽  
Inflammatory Cytokines ◽  
Lupus Erythematosus ◽  
Cytokine Production ◽  
Oxidized Ldl ◽  
Systemic Lupus ◽  
Vitamin D Levels ◽  
Pro Inflammatory Cytokines

Background The abnormal biological activity of cytokines plays an important role in the pathophysiology of both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Several studies have highlighted the association of vitamin D and certain pro-inflammatory cytokines with disease activity in SLE. However, there are limited data on the association of vitamin D and antiphospholipid antibodies (aPL) with various proinflammatory biomarkers in these patients and their relative impact on clinical outcomes. Methods The serum levels of several aPL, 25-hydroxy-vitamin D, pro-inflammatory cytokines including IFNα, IL-1β, IL-6, IL-8, IP10, sCD40L, TNFα and VEGF were measured in 312 SLE patients from the Jamaican ( n = 45) and Hopkins ( n = 267) lupus cohorts using commercial Milliplex and ELISA assays. Oxidized LDL/β2glycoprotein antigenic complexes (oxLβ2Ag) and their associated antibodies were also measured in the Jamaican cohort. Healthy controls for oxidative marker and cytokine testing were used. Results Abnormally low vitamin D levels were present in 61.4% and 73.3% of Hopkins and Jamaican SLE patients, respectively. Median concentrations of IP10, TNFα, sCD40L and VEGF were elevated in both cohorts, oxLβ2Ag and IL-6 were elevated in the Jamaican cohort, and IFNα, IL-1β and IL-8 were the same or lower in both cohorts compared to controls. IP10 and VEGF were independent predictors of disease activity, aPL, IP10 and IL-6 were independent predictors of thrombosis and IL-8, and low vitamin D were independent predictors of pregnancy morbidity despite there being no association of vitamin D with pro-inflammatory cytokines. Conclusions Our results indicate that aPL-mediated pro-inflammatory cytokine production is likely a major mechanism of thrombus development in SLE patients. We provide presumptive evidence of the role IL-8 and hypovitaminosis D play in obstetric pathology in SLE but further studies are required to characterize the subtle complexities of vitamin D’s relationship with cytokine production and disease activity in these patients.

scholarly journals Betok Fish (Anabas testudineus) Oil Decreases Inflammatory Cytokine through Increasing Vitamin D Level in Rats-induced Systemic Lupus Erythematosus

2020 ◽  
Vol 8 (A) ◽  
pp. 234-238
Author(s):  
Eddy Mart Salim ◽  
Radiyati Umi Partan ◽  
Rachmat Hidayat
Keyword(s):  
Vitamin D ◽  
Fish Oil ◽  
Lupus Erythematosus ◽  
Inflammatory Cytokine ◽  
Serum Vitamin ◽  
Positive Control ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Male Wistar Rats

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disorder marked by the production of antibodies to the cell’s core components. Vitamin D is a steroid hormone that plays a role in the regulation of cell growth, proliferation, apoptosis, and regulation of the immune system. Vitamin D deficiency is a clinical condition that worsens clinical SLE. Betok fish commonly found in South Sumatra, Indonesia, is rich in vitamin D content AIM: The aim of the study was to explore the utilization of betok fish oil as a natural source of Vitamin D that could reduce inflammation in SLE. METHODS: A total of 30 male Wistar rats (200 ± 20 g) were obtained from Eureka Research Laboratory (Palembang, Indonesia). About 30 kg of betok fish were obtained from the Palembang Fish Auction Center, South Sumatra, Indonesia. Betok fish were extracted to obtain theirs oil by heating and centrifuging processes. Thirty male Wistar rats were randomly divided into the six groups: (1) Betok fish oil Group 1 0.1 mL/kg BW group, (2) Betok fish oil Group 2 0.2 mL/kg BW group, (3) Betok fish oil Group 3 0.4 mL/kgBW group, (4) normal control group, (5) negative control group, and (6) positive control group. Enzyme-linked immunosorbent assay (ELISA) method was used to assess ds-DNA levels and Vitamin D levels. Western blot assay was used to confirm the ELISA examination of pro-inflammatory cytokine (tumor necrosis factor-alpha [TNF-α]). All data were presented as mean ± standard deviation and all statistical analyzes are performed with the SPSS 25 (IBM) program. RESULTS: This study presented that the Vitamin D content in betok fish oil is quite high at 2021.43 IU/mL. That was higher than other Vitamin D regiments on the marketplace. Moreover, this research showed that giving fish oil at a dose of 0.4 mL/kg BW is more effective than the positive control in increasing serum Vitamin D levels. These results indicate the effectiveness of betok fish oil in increasing serum Vitamin D levels in SLE-induced rats. In addition, betok fish oil was able to reduce the expression of pro-inflammatory cytokine, TNF-alpha, in serum of SLE rats. CONCLUSION: Betok fish oil has efficacy in reducing levels of ds-DNA autoantibodies in SLE rats by decreasing the inflammatory response through upregulation of Vitamin D in serum.

scholarly journals Assessment of serum vitamin D level and its relationship with disease activity in adult patients with Systemic Lupus Erythematosus (SLE)

2020 ◽  
Vol 5 (2) ◽  
pp. 73-80
Author(s):  
Zahra Bagheri-Hosseinabadi ◽  
Fatemeh Moadab ◽  
Zahra Kamiab ◽  
Amir Rahnama ◽  
Mitra Abbasifard
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Serum Vitamin ◽  
Adult Patients ◽  
Systemic Lupus ◽  
Serum Vitamin D

Vitamin D levels in male patients with systemic lupus erythematosus

2014 ◽  
Author(s):  
Cristina Vergara ◽  
Angels Martinez-Ferrer ◽  
Elvira Vicens ◽  
Elia Valls ◽  
Jose Oller ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Vitamin D Levels ◽  
Male Patients

scholarly journals To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

2018 ◽  
Vol 12 (1) ◽  
pp. 226-247 ◽  
Author(s):  
Alessandra Nerviani ◽  
Daniele Mauro ◽  
Michele Gilio ◽  
Rosa Daniela Grembiale ◽  
Myles J. Lewis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Vitamin D Supplementation ◽  
Current Evidence ◽  
Systemic Lupus ◽  
Vitamin D Receptors ◽  
Vitamin D Levels

Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal activation of the immune system, chronic inflammation and organ damage. Lupus patients are more prone to be vitamin D deficient. However, current evidence is not conclusive with regards to the role played by vitamin D in SLE development, progression, and clinical manifestations. Objective: Here, we will summarise the current knowledge about vitamin D deficiency prevalence, risk factors, molecular effects, and potential pathogenic role in SLE. We will focus on the link between vitamin D deficiency and lupus clinical manifestations, and on the clinical trials assessing the effects of vitamin D supplementation in SLE. Method: A detailed literature search was performed exploiting the available databases, using “vitamin D and lupus/SLE” as keywords. The relevant interventional trials published over the last decade have been considered and the results are reported here. Conclusion: Several immune cells express vitamin D receptors. Thus, an immunomodulatory role for vitamin D in lupus is plausible. Numerous observational studies have investigated the relationship between vitamin D levels and clinical/serological manifestations of SLE with contrasting results. Negative correlations between vitamin D levels and disease activity, fatigue, renal and cardiovascular disease, and anti-dsDNA titres have been described but not conclusively accepted. In experimental models of lupus, vitamin D supplementation can improve the disease. Interventional trials have assessed the potential therapeutic value of vitamin D in SLE, but further larger studies are needed.

Sign in / Sign up

Export Citation Format

Share Document