Control of the of the final stage of immune-mediated diabetes by ISO-1, an antagonist of macrophage migration inhibitory factor
2008 ◽
Vol 60
(3)
◽
pp. 389-401
◽
Keyword(s):
We recently showed that attenuation of inflammatory cytokine MIF with pharmacological inhibitor ISO-1 down-regulates the immune-mediated diabetes in mice. Here we explore the effects of MIF neutralization by ISO-1 on the local inflammatory pathway of the disease. In vivo treatment of mice with ISO-1 inhibited the expression of pro-inflammatory cytokines and iNOS in the pancreatic islets. Moreover, ISO-1 affected in vitro cytokine-induced NO pro?duction by fibroblasts, endothelial cells, insulinoma cells, and pancreatic islets, and rescued ? cells from NO-dependent damage. These results suggest regulatory potential of ISO-1 at the level of the pancreas which can preserve the target tissue from autoimmune attack.
2007 ◽
Vol 292
(1)
◽
pp. E272-E280
◽
2007 ◽
Vol 204
(10)
◽
pp. 2363-2372
◽
Keyword(s):
2007 ◽
Vol 26
(4)
◽
pp. 333-338
◽
Keyword(s):
2021 ◽
2017 ◽
Vol 17
(1)
◽
pp. 60-72
◽
2018 ◽
Vol 38
(3)
◽
pp. 356-370
◽