Can thyroidectomy be performed in secondary thyroid cancer?

Background: Secondary thyroid cancer is much less frequent than primary and in the majority of cases represents disseminated disease where operation on thyroid is useless or thyroid tumor is not operable, infiltrating surrounding structures. Methods: Five case reports of patients operated for secondary thyroid cancer. Results: Case 1: In male patient aged 64 years thyroidectomy was done for thyroid solid tumor 5 years after lung lobectomy for bronchogenic planocellular cancer. FNB suspected nonthyroid cancer histological analysis revealed planocellular cancer (Grimelius staining excluded medullar cancer) and multinodular goiter. Case 2: In female patient aged 65 years, thyroidectomy was done 4 years after left mastectomy with the history of long standing multinodular toxic goiter. Infiltrate remained in trachea and esophagus, histology revealed breast cancer metastasis in thyroid, confirmed with special mucin I, and estrogen receptor staining with negative thyroglobulin staining. Case 3: In female patient aged 76 years thyroidectomy was performed for metastatic lucidocellular kidney cancer in recurrent goiter (with Vimentin staining), a year after nephrectomy and 50 years after first goiter operation. Case 4: In female patient aged 58 years thyroidectomy was performed for planocellular infiltration of esophagus into the left thyroid lobe. Case 5: In female patient aged 77 years thyroidectomy was done for hemorrhage into thyrotoxic goiter, histology revealed metastasis of planocellular cancer of unknown origin into thyroid. Case 6: In male patient aged 54 years, thyroidectomy was done for thyroid metastatic lucidocellular cancer of kidney, 2 years after nephrectomy. Conclusion: Although prognosis of secondary thyroid cancer is poor, in rare cases aggressive surgery with adjuvant therapy may be successful.

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Metastatski tumorji hipofize: predstavitev treh primerov in pregled literature

Slovenian Medical Journal ◽

10.6016/zdravvestn.1385 ◽

2016 ◽

Vol 85 (7-8) ◽

Author(s):

Tomaž Šmigoc ◽

Tomaž Velnar ◽

Urša Kšela ◽

Maja Ravnik ◽

Boštjan Lanišnik ◽

...

Keyword(s):

Diabetes Insipidus ◽

Cancer Metastasis ◽

Unknown Origin ◽

B Cell Lymphoma ◽

Renal Clear Cell Carcinoma ◽

Breast Cancer Metastasis ◽

Metastatic Tumour ◽

Common Symptom ◽

Oncological Treatment ◽

Nerve Paresis

Background. Metastatic tumours to pituitary are rare. The most frequent are metastases from breast and lung.Methods. In this paper, three cases of metastatic tumours to the pituitary are presented with panhypopituitarism as a common symptom: I) a 60-year-old gentleman with metastasis of diffuse large B cell lymphoma, who presented with diabetes insipidus, II) a 54-year-old lady with metastatic renal clear cell carcinoma and consequent disturbances in visual acuity, brain nerve paresis and III) a 57-year-old lady with breast cancer metastasis, visual impairment and brain nerve paresis.Results. A transnasal endoscopic resection of the tumours was performed in all cases, followed by oncological treatment. All patients improved after the treatment.Conclusions. Despite the rarity of the disease, a metastatic tumour to the pituitary gland must be included in the differential diagnosis when symptoms such as diabetes insipidus, ophthalmoplegy due to brain nerve palsies, rapid course of the disease and headache are observed. In 20% to 30%, pituitary metastases are the first manifestation of a tumour of unknown origin. Surgical and adjuvant therapy may improve the quality of life. The survival and prognosis are generally poor.

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Breast cancer metastasis to the conjunctiva

Vojnosanitetski pregled ◽

10.2298/vsp120322040b ◽

2013 ◽

Vol 70 (3) ◽

pp. 331-334 ◽

Cited By ~ 2

Author(s):

Anica Bobic-Radovanovic ◽

Dejan Rasic ◽

Marko Buta ◽

Radan Dzodic

Keyword(s):

Breast Cancer ◽

Female Patient ◽

Cancer Metastasis ◽

Lobular Carcinoma ◽

Hepatic Metastases ◽

Radical Mastectomy ◽

Excisional Biopsy ◽

Breast Cancer Metastasis ◽

Bulbar Conjunctiva ◽

Conjunctival Lesion

Introduction. Conjunctival metastasis is exceedingly rare, and it is, as a rule, a sign of advanced malignant disease with poor prognosis. We presented a female patient with breast cancer metastasis to the conjunctiva. Case report. A 45-yearold premenopausal female patient was presented with a solitary, yellowish, thin, demarcated lesion in the superior nasal quadrant of the bulbar conjunctiva of the left eye noted by chance a week earlier. There was no sign of irritation, and no pain, and no other functional or morphological problem in either eye or orbit. Five years before the appearance of conjunctival metastasis, breast carcinoma was diagnosed and the patient underwent chemotherapy, preoperative radiotherapy and radical mastectomy. Three years later, computed tomography scan showed metastasis in the left hepatic lobe with ascites and the patient underwent chemotherapy again. But, four months prior to the appearance of conjunctival lesion body scintigraphy showed multifocal sceletal lesions and nuclear magnetic resonance revealed diffuse hepatic metastases and bilateral ovarial tumors. Paliative radiotherapy and hormonal therapy (megestrol, 160 mg) were carried out. An excisional biopsy of the observed conjunctival lesion was performed under topical anesthesia and the material was subjected to histopathological (HP) examination. HP and immunohistochemical examinations established the presence of breast infiltrating lobular carcinoma metastatic to the conjunctiva. The patient showed rapid deterioration after intervention, and died after three weeks. Conclusion. A survival period less than one month after the appearance of conjunctival metastasis deserves attention because it is unexpected and has never been reported previously. It is not a rule that HP presentation of a metastatic lesion is so characteristic that it is possible to determine a primary tumor.

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Pathological Vertebral Compression Fracture of C3 Due to a Breast Cancer Metastasis in a Male Patient

Spine ◽

10.1097/brs.0b013e3181aa2687 ◽

2009 ◽

Vol 34 (16) ◽

pp. E586-E590 ◽

Cited By ~ 2

Author(s):

Vicente Jesús López-O’Rourke ◽

Felip Orient-López ◽

Fidel Fontg-Manzano ◽

Esmeralda Fernández-Mariscal ◽

Andrés Combalía ◽

...

Keyword(s):

Breast Cancer ◽

Male Patient ◽

Cancer Metastasis ◽

Vertebral Compression Fracture ◽

Compression Fracture ◽

Breast Cancer Metastasis

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Relationship Between rhTSH Administration and Thyroid Cancer Progression: A Case Report

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.1835 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A899-A899

Author(s):

Maria G Mejia ◽

Hospital San José de Bogotá, C ◽

Luz Amaya Veronesi ◽

Diana Carolina Concha

Keyword(s):

Thyroid Cancer ◽

Case Report ◽

Cancer Progression ◽

Case Reports ◽

Bone Lesion ◽

Thyroid Tumor ◽

Parietal Bone ◽

Bone Lesions ◽

Neoplastic Progression ◽

The Right

Abstract Introduction: The relationship between the administration of recombinant TSH (rhTSH) and the progression of thyroid cancer has been described in some case reports (1). There are scant data suggesting that rhTSH acts as a growth factor that stimulates metastatic tumor expansion. Case Report: A 55 year old male patient who 3 years ago reported an evident mass at cervical level. The ultrasound documented a large thyroid mass with an endothoracic component. The FNA reported BETHESDA IV, suspicious for follicular neoplasia. Extension studies showed lytic left parietal bone lesion and liver metastatic compromise. The pathology of the total thyroidectomy showed a follicular carcinoma with a micronodular pattern and capsular invasion, of 19x9x7 cm, vascular and esophageal involvement T4BN0M1. He was sent to radioiodine therapy with 100 MCI with previous suspension of LT4 (Preablative TGL> 300 ng / ml (<50 ng / ml) Abs-TGL 2 IU / ml (<2 IU / ml) TSH 31.3 mIU / L (0.37-4.7 mIU / L) and body scan documenting uptake of the radiotracer at the left parietal, the anterior costal grating, and liver. A second dose of iodine was applied, with 150 MCI after stimulation with thyrotropin (Preablative TGL> 300 ng / ml, Abs-TGL 1.76 IU / ml, TSH 83 mIU / L) Immediately after the administration of rhTSH, the patient described the appearance of alopecic plaques on the scalp, sensation of mass at the right upper quadrant of the abdomen and bone pain in the right rib cage and at the right hip, which progressively worsened the following days until they were incapacitating. The scan report showed a new uptake in dorsal vertebrae, the MRI showed new bone injury at the innominate bone, as well as increase in the sum of its maximum dimensions by 22%, indicative of progression. The cerebral angio-MRI showed hypervascularized metastasis at the left parietal level. Bone scintigraphy documented foci of hyper uptake in both parietals, manubrium and sternal body, 5-8 right anterior costal arches, right scapula, both humeral heads, vertebral bodies T3-T5-T7L4, right acetabulum, left proximal femur and the entire length of the right femur. The clinical and imaging worsening of the bone lesions after the application of rhTSH was striking, for this reason radiotherapy and embolization of the liver lesion was performed. The patient was not a candidate for neurosurgical management due to the vascular component of the cranial lesions. Conclusion: rhTSH is a very well-tolerated method that avoids symptoms associated with severe hypothyroidism. However, it has been associated with neoplastic progression. This is one of the few cases documented in the literature where there is a direct association between the administration of rhTSH and the progression of bone metastases. References: (1)Braga M. Ringel M. Cooper DS. Sudden Enlargement of Local Recurrent Thyroid Tumor after Recombinant Human TSH Administration. J Clin Endocrinol Metab. 2001; 86(11):5148–51.

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Intravenous Administration of Vitamin C in the Treatment of Herpes Zoster-Associated Pain: Two Case Reports and Literature Review

Pain Research and Management ◽

10.1155/2020/8857287 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Yao Liu ◽

Mi Wang ◽

Miao-Miao Xiong ◽

Xue-Guang Zhang ◽

Ming Fang

Keyword(s):

Herpes Zoster ◽

Vitamin C ◽

Antiviral Therapy ◽

Female Patient ◽

Male Patient ◽

Postherpetic Neuralgia ◽

Randomized Clinical Trials ◽

Case Reports ◽

Randomized Controlled Studies ◽

The Right

Background. Herpes zoster (HZ) is an acute inflammatory neurocutaneous disease caused by the reactivation of varicella-zoster virus. It is estimated that the incidence of postherpetic neuralgia following HZ is 10–20%. The leading risk factors of the prognosis are aging and immunity dysfunction. Vitamin C plays a pivoted role in enhancing white blood cell function. Epidemiological evidence and clinical studies have indicated an association between pain and suboptimal vitamin C status. At present, vitamin C has been used as an additional option in the treatment of HZ-associated pain. Despite the current controversy, case reports and randomized controlled studies have indicated that both acute- and postherpetic neuralgia can be dramatically alleviated following intravenous vitamin C infusions. Case Presentation. Two patients (male aged 72 and female 78 years) with HZ did not respond well to antiviral therapy and analgesics. Skin lesions in the right groin and front thigh healed after early antiviral therapy, but the outbreak of pain persisted in the male patient. The female patient presented to our clinic with clusters of rashes in the right forehead with severe edema of her right upper eyelid. Because nerve blockade could not be conducted for both patients, intravenous infusion of vitamin C was applied and resulted in an immediate remission of the breakthrough pain in the male patient and cutaneous lesions in the female patient. Conclusions. The use of vitamin C appears to be an emerging treatment alternative for attenuating HZ and PHN pain. Hence, we recommend the addition of concomitant use of intravenously administered vitamin C into therapeutic strategies in the treatment of HZ-associated pain, especially for therapy-resistant cases. Furthermore, animal studies are required to determine analgesic mechanisms of vitamin C, and more randomized clinical trials are essential to further determine the optimal dose and timing of administration of vitamin C.

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Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis

Case Reports in Oncological Medicine ◽

10.1155/2021/3054232 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Áurea Lima ◽

Isa Peixoto ◽

Susana Sarandão ◽

Daniel Melo ◽

Ângelo Rodrigues ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell ◽

Tumor Metastasis ◽

Therapeutic Strategy ◽

Cancer Metastasis ◽

Renal Carcinoma ◽

Malignant Tumors ◽

Case Reports ◽

Breast Cancer Metastasis ◽

Tumor To Tumor Metastasis

The tumor-to-tumor metastasis phenomenon remains fairly uncommon, with fewer than 100 cases described to present time. Virtually any tumor can be a donor or a recipient neoplasm. Nevertheless, renal carcinomas have been implicated as the most common malignant tumors to harbor metastasis, while lung and breast tumors are the most frequent donors. This article reports an extremely rare case of a breast cancer metastasis in a lung metastasis of clear cell type renal cell carcinoma that met all Campbell and coworkers’ tumor-to-tumor metastasis criteria. Additionally, we present the literature case reports of breast cancer metastasis in renal cell carcinomas and try to discuss the mechanisms underlying its occurrence. Since this phenomenon identification will impact the therapeutic strategy and it is not easily detected by image, the anatomopathological study of any and all suspicious lesions is of crucial importance. To the best of our knowledge, this is the first report of a metastasis inside a metastasis.

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Dysplasia Epiphysealis Hemimelica of the Talus: Two Case Reports

Journal of Orthopaedic Surgery ◽

10.1177/230949900501300115 ◽

2005 ◽

Vol 13 (1) ◽

pp. 79-82 ◽

Cited By ~ 15

Author(s):

SK Bhosale ◽

DB Dholakia ◽

BA Sheth ◽

SK Srivastava

Keyword(s):

Female Patient ◽

Ankle Joint ◽

Male Patient ◽

Developmental Disorder ◽

Case Reports ◽

Surgical Excision ◽

Trevor’S Disease ◽

Dysplasia Epiphysealis Hemimelica

Trevor's disease, also known as dysplasia epiphysealis hemimelica, is an uncommon skeletal developmental disorder representing an osteochondroma occurring in one or more epiphyses. We present 2 cases of dysplasia epiphysealis hemimelica in an 8-year-old female and a 12-year-old male who suffered from a hard swelling of the ankle joint. The female patient was treated by surgical excision and the male patient conservatively.

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