scholarly journals Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Áurea Lima ◽  
Isa Peixoto ◽  
Susana Sarandão ◽  
Daniel Melo ◽  
Ângelo Rodrigues ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Renal Cell ◽  
Tumor Metastasis ◽  
Therapeutic Strategy ◽  
Cancer Metastasis ◽  
Renal Carcinoma ◽  
Malignant Tumors ◽  
Case Reports ◽  
Breast Cancer Metastasis ◽  
Tumor To Tumor Metastasis

The tumor-to-tumor metastasis phenomenon remains fairly uncommon, with fewer than 100 cases described to present time. Virtually any tumor can be a donor or a recipient neoplasm. Nevertheless, renal carcinomas have been implicated as the most common malignant tumors to harbor metastasis, while lung and breast tumors are the most frequent donors. This article reports an extremely rare case of a breast cancer metastasis in a lung metastasis of clear cell type renal cell carcinoma that met all Campbell and coworkers’ tumor-to-tumor metastasis criteria. Additionally, we present the literature case reports of breast cancer metastasis in renal cell carcinomas and try to discuss the mechanisms underlying its occurrence. Since this phenomenon identification will impact the therapeutic strategy and it is not easily detected by image, the anatomopathological study of any and all suspicious lesions is of crucial importance. To the best of our knowledge, this is the first report of a metastasis inside a metastasis.

Tumor‐to‐tumor metastasis: Breast cancer metastasis to lung cancer

2020 ◽  
Vol 26 (3) ◽  
pp. 534-535
Author(s):  
Sema Turker ◽  
Ebru Çılbır ◽  
Kerim Bora Yilmaz ◽  
Efe Yetişgin ◽  
Gökşen İmamoğlu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Tumor Metastasis ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumor To Tumor Metastasis

scholarly journals A CASE OF TUMOR-TO-TUMOR METASTASIS OF BREAST CANCER WITHIN RENAL CELL CARCINOMA

2019 ◽  
Vol 110 (4) ◽  
pp. 239-243
Author(s):  
Yousuke Shibata ◽  
Masato Yasui ◽  
Hironao Tajirika ◽  
Kazuhiro Furuya ◽  
Makoto Funahashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Metastasis ◽  
Tumor To Tumor Metastasis

Combination of Mitochondrial Targeting Doxorubicin with Bcl-2 Function Converting Peptide NuBCP-9 for Synergistic Breast Cancer Metastasis Inhibition

2021 ◽  
Author(s):  
Jiatao Yang ◽  
Qiuyi Li ◽  
Rui Zhou ◽  
Minglu Zhou ◽  
Xi Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Metastasis ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Breast Cancer Patients ◽  
Mitochondrial Targeting ◽  
Distant Organ Metastasis ◽  
Metastasis Inhibition ◽  
Organ Metastasis ◽  
Distant Organ

Distant organ metastasis is the main cause of death in breast cancer patients. Evidences have shown that mitochondria also play a crucial role in tumor metastasis, except for as apoptosis...

scholarly journals Association of gene expression with lymph node breast cancer metastasis

2020 ◽  
Vol 25 (2) ◽  
pp. 56-60
Author(s):  
K. A. Grishina ◽  
F. M. Kipkeeva ◽  
N. I. Pospekhova ◽  
V. A. Khaylenko ◽  
A. V. Karpukhin
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Tumor Metastasis ◽  
Cancer Metastasis ◽  
Tumor Tissue ◽  
Breast Cancer Metastasis ◽  
Normal Tissues ◽  
Paired Samples ◽  
New Biomarkers ◽  
Gene Expression Levels

The most serious complication of breast cancer (BC), which affects life expectancy, is metastasis of the tumor. Metastasis is the cause of more than 80% of all breast cancer deaths. After surgical treatment and the use of adjuvant therapy, metastases occur in 8% 15% of cases. This indicates the need to develop markers for the prognosis of metastasis and clarify its mechanisms for the creation of anti-metastatic therapeutic agents. In this paper, we studied the association of LOX and uPAR gene expression with breast cancer metastasis in the lymph nodes. Gene expression was measured using real-time PCR in 40 paired samples (tumor-normal tissues). As a result of processing the measurements, the values of gene expression levels in the tumor tissue relative to normal were obtained. It is shown that the LOX gene is expressed in the tumor both lower and higher relative to the norm, and uPAR is expressed in most cases higher. In metastatic tumors, the frequency of expression increases above the norm for both LOX and uPAR genes. The association of expression of these genes with lymphatic metastasis was found: p = 0.01 and p = 0.02, for the LOX and uPAR genes, respectively. The relative risk (RR) was for the LOX gene RR = 1.9, 95% CI 1.2 3, p = 0.005, for uPAR RR = 3.6, 95% CI 1.2 10.9, p = 0.03. Thus, the data obtained contribute to understanding the mechanisms of metastasis and provide the basis for the development of new biomarkers. The LOX and uPAR genes may be candidates for predictive markers of breast cancer metastasis risk.

scholarly journals MT1-MMP: Endosomal delivery drives breast cancer metastasis

2015 ◽  
Vol 211 (2) ◽  
pp. 215-217 ◽  
Author(s):  
Stefan Linder
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Tumor Metastasis ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Invasive Tumor ◽  
Membrane Type

The membrane-tethered membrane type 1–matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.

Identification of Seven Hub Genes as the Novel Biomarkers in Triple-negative Breast Cancer and Breast Cancer Metastasis

2020 ◽  
Author(s):  
Huanxian Wu ◽  
Huining Lian ◽  
Qianqing Chen ◽  
Jinlamao Yang ◽  
Baofang Ou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Protein Interactions ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Malignant Tumors ◽  
Underlying Disease ◽  
Breast Cancer Metastasis ◽  
Hub Genes ◽  
Cancer Subtypes

Abstract Background: Breast cancer is one of the most common malignant tumors with the highest morbidity and mortality among women. Compared with the other breast cancer subtypes, Triple-negative breast cancer (TNBC) has a higher probability of recurrence and is prone to distant metastasis. To reveal the underlying disease mechanisms and identify more effective biomarkers for TNBC and breast cancer metastasis. Methods: Gene Ontology and KEGG pathway analysis were used for investigating the role of overlapping differentially expressed genes (DEGs). Hub genes among these DEGs were determined by the protein-protein interactions network analysis and CytoHubba. Oncomine databases were used for verifying the clinical relevance of hub genes. Furthermore, the differences in the expression of these genes in cancer and normal tissues were validated in the cellular, animal and human tissue.Results: Seven hub genes, including TTK, KIF11, SPAG5, RRM2, BUB1, CDCA8 and CDC25C, were identified that might be associated with TNBC and breast cancer metastasis. Meanwhile, these genes have been verified highly expressed in tumor cells and tumor tissues, and patients with higher expression of these genes have a poorer prognosis. Conclusions: Seven hub genes were potential biomarkers for the diagnosis and therapy of TNBC and breast cancer metastasis.

scholarly journals Secondary Tumors of the Ampulla of Vater: A Tale of Two Cases

2021 ◽  
Author(s):  
Jafer Ali ◽  
Asad Khan ◽  
Mohamed H. Ahmed ◽  
Ravi Madhotra
Keyword(s):  
Breast Cancer ◽  
Renal Cell Cancer ◽  
Renal Cell ◽  
Cancer Metastasis ◽  
Cell Cancer ◽  
Ampulla Of Vater ◽  
Breast Cancer Metastasis ◽  
Secondary Tumors ◽  
History Of ◽  
Upper Gastrointestinal

AbstractWe report two cases of women with metastatic cancers to ampulla of Vater. The first was 91 years old and presented with severe anemia, due to upper gastrointestinal bleeding. She had history of renal cell cancer treated with nephrectomy 8 years ago and diagnosis confirmed to be metastasis of renal cell cancer to ampulla of Vater. The second patient was 54 years old with breast cancer, metastasis and developed obstructive jaundice; diagnosis confirmed to be breast metastasis in the ampulla of Vater. Secondary tumors of the ampulla of Vater due to breast cancer and renal cell cancer are rare findings and prognosis can be poor.

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