scholarly journals Presence of Candida albicans in potentially malignant oral mucosal lesions

2004 ◽  
Vol 12 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Nada Vuckovic ◽  
Marija Bokor-Bratic ◽  
Dejan Vuckovic ◽  
Ivana Picuric
Keyword(s):  
Candida Albicans ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Viral Infections ◽  
Oral Candidiasis ◽  
Candida Infection ◽  
Lower Lip ◽  
Oral Mucosal Lesions ◽  
Potentially Malignant ◽  
Mucosal Lesions

Recently, an interest in the study of oral candidiasis has markedly increased mainly because of its association with viral infections due to human immunodeficiency, but also because of its relation with potentially malignant lesions of oral mucosa. These lesions belong to the wide group of leukoplakia. Leukoplakia is a clinical term used to describe a range of nonspecific white lesions, whose appearance does not generally correlate well with histopathologic changes; therefore, biopsy should be performed in all cases to determine which are precancerous or potentially malignant ones. In order to study the association of Candida albicans and the types of mucosal lesions, we took 30 consecutive biopsies of oral mucosa and the smears for microbiologic examination from the changed surface of mucosa and from the rest of oral cavity. The study group consisted of 30 patients, 21 women and 9 men, with the average age of 50.23 years (range, 25-77 years). In 6 cases Candida was diagnosed in mucosal biopsy. In the smear from the lesion, it was present in 3 cases, and 2 cases were found in the smear from an unchanged oral mucosa. In 9/30 cases (30%) Candida was positive regardless of the smear area or mode of diagnosis. The most common lesion is leukoplakia, diagnosed in 12/30 cases (40%), in 6 female and 6 male patients. The average age of those patients was 52.42 years. The lesions were located as follows: cheek mucosa - 5 cases; gingival mucosa - 2; lower lip - 2; floor of the mouth - 2; soft palate - 1; Candida was present in 3/12 cases. The lesion with the second highest incidence is lichen planus (9 cases), with positive Candida infection in 4/9 (44.44%). Epithelial dysplasia, although diagnosed in a very small number of cases (1/30 or 3.3%) with leukoplakia, was associated with a Candida infection. Generally, Candida is present in potentially malignant oral mucosal lesions (in 3/12 or 25% of leukoplakia cases, in 4/9 or 44.44% of lichen planus cases, and 1/1 squamous papilloma), with an increasing incidence in lesions with serious dysplastic epithelial changes.

scholarly journals Candida albicans infection in patients with oral squamous cell carcinoma

2010 ◽  
Vol 67 (9) ◽  
pp. 766-770 ◽  
Author(s):  
Milos Cankovic ◽  
Marija Bokor-Bratic
Keyword(s):  
Squamous Cell Carcinoma ◽  
Candida Albicans ◽  
Alcohol Consumption ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Candida Species ◽  
Control Group ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions ◽  
Cancer Lesion

Bacground/Aim. Systemic candidiasis in intensive care units remains an improtant problem due to antifungal resistance. Patients undergoing radiotherapy for head and neck cancer are at increased risk of developing oral candidiasis and they more frequent have prior fungi colonization. Due to identification of specific risk factors predisposing to fungal infection in order to threat such patients the aim of this study was to determine the presence of Candida species in patients with oral squamous cell carcinoma and compare it to the control subjects (patients with benign oral mucosal lesions). Methods. A total number of 30 consecutive oral cancer examined patients were included in this prospective study (24 men and 6 women with a mean age of 61.47 years, range 41-81 years). The control group consisted of 30 consecutive patients with histologically proven benign oral mucosal lesions (16 men and 14 women with a mean age of 54.53 years, range 16- 83 years). The samples for mycological examination were obtained by using sterile cotton swabs from the cancer lesion surface and in the patients of the control group from the benign mucosal lesion surface. Samples were inoculated in Sabouraud' dextrose agar. For identification purposes, Mackenzie germ tube test was performend on all isolates. Results. The prevalence of Candida was significantly higher in oral cancer patients than in control subjects (?2 = 5.455, p = 0.020). Candida was found on nine of the 30 cancer surfaces; 5 (16.7%) were identified as non-albicans Candida and 4 (13.3%) as Candida albicans. In the control group, only Candida albicans was isolated from 2 (6.7%) patients. In this study, no statistically significant differences in the presence of Candida species was found with respect to gender, age, smoking, alcohol consumption, wearing of dental protheses and the site of cancer lesion. Conclusion. The increased prevalence of yeasts on the surfaces of oral carcinoma indicates a need for their suppression before any cancer treatment. There was no evidence for an association between gender, age, smoking, alcohol consumption, wearing of dental protheses, the site of cancer lesion and the yeast presence.

scholarly journals Prevalence of Oral Mucosal Lesions in a Tertiary Care Dental Hospital of Kathmandu

2017 ◽  
Vol 56 (207) ◽  
pp. 362-366
Author(s):  
Dipshikha Bajracharya ◽  
Sujaya Gupta ◽  
Bidhata Ojha ◽  
Radha Baral
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Buccal Mucosa ◽  
Tertiary Care ◽  
Oral Mucosal Lesions ◽  
Dental Hospital ◽  
Mucosal Lesions

Introduction: Oral mucosa can be affected by a variety of soft tissue lesions and conditions. Benign as well as malignant lesions of oral cavity are common. Squamous cell carcinoma is one of the commonest malignancies. The present retrospective study was undertaken to study the prevalence of various oral mucosal lesions in a tertiary care dental hospital of Kathmandu. Methods: This retrospective study was carried out in the Department of Oral and Maxillofacial Pathology at Kantipur Dental College and Teaching hospital from January 2015 to January 2017. The study included biopsy specimen from the oral cavity. The parameters included in the study were age, gender, site of the lesion and histopathological diagnosis. The data collected was statistically analyzed. Results: A total of 111 biopsy cases were included in the present study. Out of which, there was 16 (14.4%) cases of non neoplastic and 16 (14.4%) cases of benign pathology. The oral cavity lesions were commonly seen in age range between 6-74 years where males 59 (53.2%) were mostly affected. The most common site for oral lesion was buccal mucosa 23 (20.7%) and anterior gingiva 23 (20.7%). 15 (13.5%) cases of oral squamous cell carcinoma were seen as the predominant malignancy affecting in the vestibular region 8 (7.2%). Conclusions: The present study shows benign as well as the non neoplastic lesions were more prevalent in oral mucosa with the buccal mucosa and anterior gingiva as the commonest site of occurrence. Keywords: Benign; Malignant; Non neoplastic; Oral mucosal lesion.

scholarly journals Prevalence of Potentially Malignant Oral Mucosal Lesions among Tobacco Users in Jeddah, Saudi Arabia

2014 ◽  
Vol 15 (2) ◽  
pp. 757-762 ◽  
Author(s):  
Safia Ali Al-Attas ◽  
Suzan Seif Ibrahim ◽  
Hala Abbas Amer ◽  
Zeinab El-Said Darwish ◽  
Mona Hassan Hassan
Keyword(s):  
Saudi Arabia ◽  
Oral Mucosal Lesions ◽  
Potentially Malignant ◽  
Mucosal Lesions

PD.221 Viral DNA in potentially malignant andmalignant oral mucosal lesions

2005 ◽  
Vol 1 (1) ◽  
pp. 134
Author(s):  
A. Faden ◽  
D. Moles ◽  
C.G. Teo ◽  
S.R. Porter
Keyword(s):  
Viral Dna ◽  
Oral Mucosal Lesions ◽  
Potentially Malignant ◽  
Mucosal Lesions

Management of potentially malignant oral mucosal lesions by consultant UK oral and maxillofacial surgeons

1996 ◽  
Vol 34 (1) ◽  
pp. 28-36 ◽  
Author(s):  
J.J. Marley ◽  
C.G. Cowan ◽  
P.-J. Lamey ◽  
G.J. Linden ◽  
N.W. Johnson ◽  
...  
Keyword(s):  
Oral Mucosal Lesions ◽  
Potentially Malignant ◽  
Mucosal Lesions

Prevalence of oral cancer, oral potentially malignant disorders and other oral mucosal lesions in Cambodia

2016 ◽  
Vol 23 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Tepirou Chher ◽  
Sithan Hak ◽  
Thomas George Kallarakkal ◽  
Callum Durward ◽  
Anand Ramanathan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Oral Potentially Malignant Disorders ◽  
Oral Mucosal Lesions ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Mucosal Lesions

scholarly journals Therapeutic alternative for oral lichen planus treatment in an unusual location: case report

2021 ◽  
Vol 10 (5) ◽  
pp. 734-739
Author(s):  
Thaís Torres Barros Dutra ◽  
Thâmara Manoela Marinho Bezerra ◽  
Filipe Nobre Chaves ◽  
Sthefane Gomes Feitosa ◽  
Fábio Wildson Gurgel Costa ◽  
...  
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Topical Therapy ◽  
Malignant Lesion ◽  
Basal Layer ◽  
Lower Lip ◽  
Therapeutic Alternative ◽  
Potentially Malignant ◽  
Oral Lichen

Oral Lichen Planus (OLP) is considered a potentially malignant lesion (PML), although its rate of transformation is controversial. New treatments have been introduced recently, for example calcipotriene (D3 vitamin analog). Its incremental action with glucocorticoids is observed and isolated lip lesions may respond positively to combined topical therapy. Thus, objective of this case report is to show a therapeutic alternative for isolated and persistent OLP lip lesions. An 18-year-old teenager was referred to evaluate an erythematous lower lip lesion with approximately 10 years of evolution. The inspection revealed multiple erythematous areas surrounded by thin whitish streaks located in the vermilion of the lower lip. No abnormalities in the skin, nails, scalp or other areas of oral mucosa were observed. The incisional biopsy was performed and the microscopic exam showed areas of basal layer degeneration with intense mononuclear inflammatory infiltrate banded and predominantly subepithelial. The therapeutic proposal was topical application of Daivobet®, a combination of topical corticosteroids and vitamin D derivative. The lesion had remission after the fifteen days, medication was suspended and indicated when there was a relapse. During follow-up, no recurrences or complications were observed. That combination therapy may be a new approach in treating OLP.

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