Amalgam associated mercury accumulations in normal oral mucosa, oral mucosal lesions of lichen planus and contact lesions associated with amalgam

1990 ◽  
Vol 19 (1) ◽  
pp. 39-42 ◽  
Author(s):  
J. Bolewska ◽  
P. Holmstrup ◽  
B. Moller-Madsen ◽  
B. Kenrad ◽  
G. Danscher
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Normal Oral Mucosa ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Presence of Candida albicans in potentially malignant oral mucosal lesions

2004 ◽  
Vol 12 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Nada Vuckovic ◽  
Marija Bokor-Bratic ◽  
Dejan Vuckovic ◽  
Ivana Picuric
Keyword(s):  
Candida Albicans ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Viral Infections ◽  
Oral Candidiasis ◽  
Candida Infection ◽  
Lower Lip ◽  
Oral Mucosal Lesions ◽  
Potentially Malignant ◽  
Mucosal Lesions

Recently, an interest in the study of oral candidiasis has markedly increased mainly because of its association with viral infections due to human immunodeficiency, but also because of its relation with potentially malignant lesions of oral mucosa. These lesions belong to the wide group of leukoplakia. Leukoplakia is a clinical term used to describe a range of nonspecific white lesions, whose appearance does not generally correlate well with histopathologic changes; therefore, biopsy should be performed in all cases to determine which are precancerous or potentially malignant ones. In order to study the association of Candida albicans and the types of mucosal lesions, we took 30 consecutive biopsies of oral mucosa and the smears for microbiologic examination from the changed surface of mucosa and from the rest of oral cavity. The study group consisted of 30 patients, 21 women and 9 men, with the average age of 50.23 years (range, 25-77 years). In 6 cases Candida was diagnosed in mucosal biopsy. In the smear from the lesion, it was present in 3 cases, and 2 cases were found in the smear from an unchanged oral mucosa. In 9/30 cases (30%) Candida was positive regardless of the smear area or mode of diagnosis. The most common lesion is leukoplakia, diagnosed in 12/30 cases (40%), in 6 female and 6 male patients. The average age of those patients was 52.42 years. The lesions were located as follows: cheek mucosa - 5 cases; gingival mucosa - 2; lower lip - 2; floor of the mouth - 2; soft palate - 1; Candida was present in 3/12 cases. The lesion with the second highest incidence is lichen planus (9 cases), with positive Candida infection in 4/9 (44.44%). Epithelial dysplasia, although diagnosed in a very small number of cases (1/30 or 3.3%) with leukoplakia, was associated with a Candida infection. Generally, Candida is present in potentially malignant oral mucosal lesions (in 3/12 or 25% of leukoplakia cases, in 4/9 or 44.44% of lichen planus cases, and 1/1 squamous papilloma), with an increasing incidence in lesions with serious dysplastic epithelial changes.

scholarly journals Prevalence of Oral Mucosal Lesions in a Tertiary Care Dental Hospital of Kathmandu

2017 ◽  
Vol 56 (207) ◽  
pp. 362-366
Author(s):  
Dipshikha Bajracharya ◽  
Sujaya Gupta ◽  
Bidhata Ojha ◽  
Radha Baral
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Buccal Mucosa ◽  
Tertiary Care ◽  
Oral Mucosal Lesions ◽  
Dental Hospital ◽  
Mucosal Lesions

Introduction: Oral mucosa can be affected by a variety of soft tissue lesions and conditions. Benign as well as malignant lesions of oral cavity are common. Squamous cell carcinoma is one of the commonest malignancies. The present retrospective study was undertaken to study the prevalence of various oral mucosal lesions in a tertiary care dental hospital of Kathmandu. Methods: This retrospective study was carried out in the Department of Oral and Maxillofacial Pathology at Kantipur Dental College and Teaching hospital from January 2015 to January 2017. The study included biopsy specimen from the oral cavity. The parameters included in the study were age, gender, site of the lesion and histopathological diagnosis. The data collected was statistically analyzed. Results: A total of 111 biopsy cases were included in the present study. Out of which, there was 16 (14.4%) cases of non neoplastic and 16 (14.4%) cases of benign pathology. The oral cavity lesions were commonly seen in age range between 6-74 years where males 59 (53.2%) were mostly affected. The most common site for oral lesion was buccal mucosa 23 (20.7%) and anterior gingiva 23 (20.7%). 15 (13.5%) cases of oral squamous cell carcinoma were seen as the predominant malignancy affecting in the vestibular region 8 (7.2%). Conclusions: The present study shows benign as well as the non neoplastic lesions were more prevalent in oral mucosa with the buccal mucosa and anterior gingiva as the commonest site of occurrence. Keywords: Benign; Malignant; Non neoplastic; Oral mucosal lesion.

scholarly journals Overexpression and Selectively Regulatory Roles of IL-23/IL-17 Axis in the Lesions of Oral Lichen Planus

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Rui Lu ◽  
Xin Zeng ◽  
Qi Han ◽  
Mu Lin ◽  
Long Long ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Immune Disorders ◽  
Oral Keratinocytes ◽  
Regulatory Pathway ◽  
Normal Oral Mucosa ◽  
Oral Lichen

Interleukin- (IL-) 23/IL-17 axis is a newly discovered proinflammatory signaling pathway and has been implicated in the pathogenesis of many chronic inflammatory and immune disorders. Here we investigated whether the IL-23/IL-17 axis was present and functional in the lesions of oral lichen planus (OLP), a chronic inflammatory disease affecting the oral mucosa. Using immunohistochemistry and quantitative PCR, we found that the subunits of IL-23 and IL-17 were overexpressed in OLP lesions than in normal oral mucosa tissues. In addition, the expressions of IL-23 and IL-17 are positively correlated in reticular OLP tissues. Results from in vitro studies revealed that exogenous IL-23 could increase the percentage of Th17 cells and IL-17 production in the CD4+T cells from reticular OLP patients. Furthermore, we also found that exogenous IL-17 could significantly enhance the mRNA expressions ofβ-defensin-2, -3, CCL-20, IL-8, and TNF-α, but notβ-defensin-1, CXCL-9, -10, -11, CCL-5, and IL-6 in human oral keratinocytes. Taken together, our results revealed an overexpression pattern and selectively regulatory roles of IL-23/IL-17 axis in the OLP lesions, suggesting that it may be a pivotal regulatory pathway in the complex immune network of OLP lesions.

scholarly journals Assessment of Cytological Atypia, AgNOR and Nuclear Area in Epithelial Cells of Normal Oral Mucosa Exposed to Toombak and Smoking

Rare Tumors ◽  
2009 ◽  
Vol 1 (1) ◽  
pp. 28-30 ◽  
Author(s):  
Hussain Gadelkarim Ahmed ◽  
Abd-Elraheem Ali Babiker
Keyword(s):  
Epithelial Cells ◽  
Proliferative Activity ◽  
Nuclear Area ◽  
Cytological Atypia ◽  
Squamous Cells ◽  
Normal Oral Mucosa ◽  
Oral Mucosal Lesions ◽  
The Mean ◽  
Mucosal Lesions ◽  
Microscopic Stage

The purpose of this study was to assess cellular proliferative activity of clinically healthy oral mucosal epithelial cells of toombak dippers and smokers by means of AgNOR counts and nuclear areas via nuclear morphometry. Smears were collected from normal-appearing mouth floor mucosa and tongue of 75 toombak dippers, 75 smokers and 50 non-tobacco users between the ages of 20 and 70 with a mean age of 36 years. AgNORs were counted in the first 50 well-fixed, nucleated squamous cells and nuclear areas were calculated via microscopic stage micrometer. Cytological atypia was ascertained in 6 tobacco users and could not be ascertained in non-tobacco users. Statistically mean AgNOR numbers per nucleus in the non-tobacco users (2.45±0.30) was lower than the toombak dippers (3.081±0.39, p<0.004), and the smokers (2.715±0.39, p<0.02), and mean nuclear areas of epithelial cells of toombak dippers (6.081±0.39, p<0.009) and smokers (5.68±10.08, p<0.01) was also significantly higher than non-smokers (5.39±9.4). The mean number of nuclei having more than 3 AgNORs was 28%, 19% and 7% in toombak dippers, smokers and non-tobacco users, respectively. These findings support the view that toombak dipping and smoking are severe risk factors for oral mucosal proliferative lesions and exfoliative cytology is valid for screening of oral mucosal lesions.

scholarly journals A Study to evaluate the Frequency and Association of Various Mucosal Conditions among Geriatric Patients

2013 ◽  
Vol 14 (5) ◽  
pp. 904-910 ◽  
Author(s):  
RGK Shet ◽  
Shobith R Shetty ◽  
M Kalavathi ◽  
M Naveen Kumar ◽  
Rishi Dev Yadav ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Geriatric Patients ◽  
Age Groups ◽  
Geriatric Dentistry ◽  
Group I ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

ABSTRACT Geriatric dentistry or gerodontics is the delivery of dental care to older adults involving the diagnosis, prevention and treatment of problems associated with normal aging and age-related diseases as part of an interdisciplinary team with other health care professionals. Aim To evaluate the oral mucosal status in the elderly population of different age group and find out the association of age, gender and denture with oral mucosal disorders. Materials and methods The study sample consisted of 570 geriatric persons concentrating mainly on the oral mucosal changes or lesions occurring in the geriatric population. Individuals those are aged above 60 years were selected, and all the examined geriatric persons were categorized into 3 age groups to find out the association of oral mucosal lesions in each group. Group I—60 to 65 years, Group II—66 to 70 years, Group III—71 and above years. Results The sample of 570 elderly patients included 279 (48.95%) men and 291 (51.05%) women in three age groups: 61 to 65 years (40.35%), 66 to 70 years (31.05%), and 71 years and older (28.60%). The sample included 254 (44.56%) dentate patients, 205 (35.96%) denture wearers (partial and complete denture wearers) and 111 (19.47%) edentulous persons who lacked dentures in both the jaws. Almost half of the patients examined (48%) had one or more oral mucosal lesions. The 48% of the patients who presented with oral mucosal lesions, twenty five different oral mucosal conditions were identified and the three most common findings were lingual varices (13.68%), denture induced inflammatory fibrous hyperplasia (4.21%), squamous cell carcinoma (4.21%). There was some differences in the distribution of oral mucosal condition among the sexes. Leukoplakia and dysplasia were significantly associated with men (p < 0.001) whereas the association of fibroma and lichen planus with women were significant (p < 0.001). Conclusion In our study it was found that patients in groups II and III had more prevalence of oral mucosal disorders. Lingual varices, oral squamous cell carcinoma, fibroma and denture induced inflammatory fibrous hyperplasia were more commonly associated with the geriatric patients. The oral lesions (fibroma and lichen planus) were strongly associated with women while leukoplakia was strongly associated with men. Ageing is an important factor that can influence the occurrence of mucosal lesions and with age the oral mucosa becomes more permeable to noxious substances and more vulnerable to external carcinogens. How to cite this article Shet RGK, Shetty SR, M Kalavathi, Kumar MN, Yadav RD, S Soumya. A Study to evaluate the Frequency and Association of Various Mucosal Conditions among Geriatric Patients. J Contemp Dent Pract 2013;14(5):904-910.

scholarly journals THE IMPORTANT ROLE OF ORAL MEDICINE SPECIALIST IN MANAGEMENT OF STEVENS-JOHNSON SYNDROME PATIENT

2020 ◽  
Vol 5 (2) ◽  
pp. 165
Author(s):  
Nuri Fitriasari ◽  
Eko Rotary Nurtito ◽  
Nanan Nur’aeny ◽  
Indah Suasani Wahyuni
Keyword(s):  
Case Report ◽  
Oral Mucosa ◽  
Electrolyte Imbalance ◽  
Stevens Johnson Syndrome ◽  
Oral Medicine ◽  
Johnson Syndrome ◽  
Mucosal Involvement ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

ABSTRACTIntroduction: Stevens-Johnson Syndrome (SJS) is an acute hypersensitivity reaction that manifests on the skin, oral mucosa, ocular, gastrointestinal, genital and anal area. It is also potentially life-threatening in concern of dehydration and infection. Oral mucosal lesions due to SJS resulted in a significant decrease of patient’s quality of life. When the oral mucosa involved, the intake of nutrients and fluids is disrupted contributing to electrolyte imbalance that aggravates dehydration. Moreover, oral mucosal lesions have become an entry point for infection. Purpose: This case report describes the important role of oral medicine specialists in the management of oral mucosal lesions in SJS patient. Review: A 26-year-old female patient was referred from the Department of Dermatology and Venereology with a diagnosis of SJS et causa suspected paracetamol and/or amoxycillin. The complaints comprised of pain on the lips and oral cavity, difficulty in mouth opening, and pain when swallowing. The management for oral lesions included: history taking, external and intra oral examinations, dexamethasone mouthwash, nystatin oral suspension, and sodium chloride (NaCl) 0.9% solution. The patient showed improvement in oral mucosal lesions within 3 weeks of treatment that was provided by oral medicine specialist and medical team collaboration. Conclusion: Based on this case report, the role of oral medicine specialist is very important as part of the management team for SJS patient. Oral medicine specialist can reduce morbidity that results from oral mucosal involvement. Collaboration with oral medicine specialist since the beginning of treatment is the key to success in SJS management. Keywords: Oral medicine specialist, Oral mucosal lesion, Stevens-Johnson Syndrome.

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