An efficient one-pot synthesis of highly substituted furans catalyzed by N-bromosuccinimide
2010 ◽
Vol 75
(3)
◽
pp. 299-305
◽
N-Bromosuccinimide was found to efficiently catalyze the synthesis of highly functionalized, tetra-substituted furan derivatives in the one-pot reactions of but-2-ene-1,4-diones and acetoacetate esters in the presence of i-PrOH as solvent under mild and neutral conditions at 80-90?C for 3-7 h in high yields (87-94%).