scholarly journals Synthesis and characterization of divalent metal complexes of the macrocyclic ligand derived from isatin and 1,2- diaminobenzene

2011 ◽  
Vol 76 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Pal Singh ◽  
Vidhi Grover ◽  
Krishan Kumar ◽  
Kiran Jain
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Far Infrared ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
Infrared Spectral

A novel series of complexes of the type [M(C28H18N6)X2], where M=Co(II), Ni(II), Cu(II) or Zn(II) and X=Cl-, NO3- or CH3COO-, were synthesized by template condensation of isatin and 1,2-diaminobenzene in methanolic medium. The complexes were characterized with the help of various physico-chemical techniques, such as elemental analyses, molar conductance measurements, magnetic measurements, and NMR, infrared and far infrared spectral studies. The low value of molar conductance indicates them to be non-electrolytes. Based on various studies, a distorted octahedral geometry may be proposed for all the complexes. All the synthesized macrocyclic complexes were also tested for their in vitro antibacterial activity against some pathogenic bacterial strains. The MIC values shown by the complexes against these bacterial strains were compared with those of the standard antibiotics linezolid and cefaclor. Some of the complexes showed good antibacterial activities.

scholarly journals Template synthesis and characterization of biologically active transition metal complexes comprising 14-membered tetraazamacrocyclic ligand

2010 ◽  
Vol 75 (2) ◽  
pp. 217-228 ◽  
Author(s):  
Dharmpal Singh ◽  
Krishan Kumar ◽  
Ramesh Kumar ◽  
Jitender Singh
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Salmonella Typhi ◽  
Molar Conductance ◽  
Biologically Active ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
In Vitro Antibacterial Activity ◽  
Active Transition

A novel series of complexes of the type [M(C28H24N4)X2], where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X = Cl-, NO3 -, CH3COO- and (C28H24N4) corresponds to the tetradentate macrocyclic ligand, were synthesized by template condensation of 1,8-diaminonaphthalene and diacetyl in the presence of divalent metal salts in methanolic medium. The complexes were characterized by elemental analyses, conductance and magnetic measurements, as well as by UV/Vis, NMR, IR and MS spectroscopy. The low values of the molar conductance indicate non-electrolyte type of complexes. Based on these spectral data, a distorted octahedral geometry may be proposed for all of these complexes. All the synthesized macrocyclic complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, viz Bacillus cereus, Salmonella typhi, Escherichia coli and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains were compared with the MIC shown by the standard antibiotics linezolid and cefaclor.

scholarly journals Synthesis and Characterization of Biologically Active 10-Membered Tetraazamacrocyclic Complexes of Cr(III), Mn(III), and Fe(III)

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Dharam Pal Singh ◽  
Vandna Malik ◽  
Ramesh Kumar
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Metal Ion ◽  
Inhibitory Concentration ◽  
Macrocyclic Ligand ◽  
Far Infrared ◽  
Carbonyl Oxygen ◽  
Biologically Active ◽  
Spectral Studies ◽  
Bacterial Strains

A new series of macrocyclic complexes of type [M(TML)X]X2; where M = Cr(III), Mn(III), or Fe(III); TML is tetradentate macrocyclic ligand and X = Cl−1, NO3−1, CH3COO−1 for Cr(III), Fe(III), and X = CH3COO−1 for Mn(III) has been synthesized by template condensation of succinyldihydrazide and glyoxal. The complexes have been formulated as [M(TML)X]X2 due to 1:2 electrolytic natures of these complexes as shown by conductivity measurements. The complexes have been characterized with the help of elemental analyses, molar conductance, electronic, infrared, far infrared spectral studies and magnetic susceptibilities. On the basis of these studies, a five-coordinate distorted square-pyramidal geometry, in which two nitrogens and two carbonyl oxygen atoms are suitably placed for coordination toward the metal ion, has been proposed for all the complexes. The complexes were tested for their in vitro antibacterial activity. Some of the complexes showed remarkable antibacterial activities against some selected bacterial strains. The minimum inhibitory concentration shown by these complexes was compared with minimum inhibitory concentration shown by some standard antibiotics like linezolid and cefaclor.

scholarly journals Trivalent metal ion directed synthesis and characterization of macrocyclic complexes

2007 ◽  
Vol 72 (11) ◽  
pp. 1069-1074 ◽  
Author(s):  
Pal Singh ◽  
Ramesh Kumar
Keyword(s):  
Metal Ion ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Macrocyclic Ligand ◽  
Far Infrared ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Molecular Weight Determination ◽  
Trivalent Metal ◽  
Pyramidal Geometry

A novel series of complexes of the type [M(TML)X]X2, where TML is a tetradentate macrocyclic ligand, M = Cr(III), Mn(III) or Fe(III), X = Cl-, CH3COO- or ? NO3, were synthesized by template condensation of dibenzoyl and thiocarbohydrazide in the presence of trivalent metal salts in a methanolic medium. The complexes were characterized with the help of elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. The electronic spectra together with the magnetic moments suggest five coordinate square pyramidal geometry for these complexes. The molar conductance indicates them to be 1:2 electrolytes.

scholarly journals Synthesis, Characterization, and Biological Activity ofN′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jonnie N. Asegbeloyin ◽  
Oguejiofo T. Ujam ◽  
Emmanuel C. Okafor ◽  
Ilknur Babahan ◽  
Esin Poyrazoglu Coban ◽  
...  
Keyword(s):  
Magnetic Measurements ◽  
Structure Study ◽  
Molar Conductance ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
X Ray ◽  
Gram Positive Bacteria

Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gaveN′-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL1), which was characterized by NMR spectroscopy and single-crystal X-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. The reaction of HL1with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies. The compounds were screened for theirin vitrocytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. Results showed that the compounds are potent against HL-60 cells with the IC50value ≤5 μM, while some of the compounds were active against few studied Gram-positive bacteria.

scholarly journals Synthesis, Characterization and Antibacterial Activities of New Bivalent Complexes of Transition Metals

2019 ◽  
Vol 31 (9) ◽  
pp. 1926-1930
Author(s):  
Veenu Chugh ◽  
Sangeeta Sharma ◽  
Rimpi Mehani Ne'e Chopra
Keyword(s):  
Magnetic Measurements ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Gram Positive Bacteria ◽  
Diffusion Technique ◽  
Complexes Of Transition Metals ◽  
Thermal Stability Of

This paper describes the synthesis, spectral studies and antimicrobial properties of the complexes with the formula [M(C30H24N4O2)Cl2], where M = Fe(II), Co(II), Ni(II), Zn(II) and Cu(II). These complexes were prepared by yield effective template condensation of hexamethylenediamine and 2,2-dihydroxyindane-1,3-dione(ninhydrin). The synthesized complexes were characterized by elemental analysis, infrared spectra, thermogravimetric analysis, Mass spectrum, 13C NMR, molar conductance, electronic spectra, magnetic measurements. TGA and X-ray diffraction studies were used to ascertain the crystal structure and thermal stability of the complexes. The antimicrobial properties of complexes against two Gram-positive bacteria and two Gram-negative bacteria were evaluated by Agar well diffusion technique. Streptomycin and chloramphenicol were taken as standard antibiotics. The results shows that some of the complexes have potential to act as antibacterial agents.

scholarly journals Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-pyran-2-one

2011 ◽  
Vol 76 (9) ◽  
pp. 1237-1246 ◽  
Author(s):  
Vaibhav Patange ◽  
Balasaheb Arbad
Keyword(s):  
Metal Complexes ◽  
Magnetic Measurements ◽  
Octahedral Geometry ◽  
Biological Study ◽  
Distorted Octahedral Geometry ◽  
Curvularia Lunata ◽  
Bacterial Strains ◽  
Biological Studies ◽  
Vis Spectroscopy

The solid complexes of Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-methyl-2H-pyran-2-one, derived from 3-acetyl-6-methyl-2H-pyran- 2,4(3H)-dione (dehydroacetic acid) and 4-hydroxy benzaldehyde, were synthesized and characterized by elemental analysis, conductometry, thermal analysis, magnetic measurements, IR, 1H-NMR and UV-VIS spectroscopy and a biological study. From the analytical and spectral data, the stoichiometry of the complexes was found to be 1:2 (metal:ligand). The physico-chemical data suggest a distorted octahedral geometry for the Cu(II) complexes and an octahedral geometry for all the other complexes. The thermal decomposition of all the complexes was studied by the TG- DTA method. The synthesized ligand and its metal complexes were screened for their in vitro antibacterial activity against Gram negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Aspergillus flavus, Curvularia lunata and Penicillium notatum. The results of these studies showed the metal complexes to be more antibacterial/antifungal against one or more species as compared with the non-complexed ligand.

scholarly journals Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Aurora Reiss ◽  
Mariana Carmen Chifiriuc ◽  
Emilia Amzoiu ◽  
Cezar Ionuţ Spînu
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Chemical Properties ◽  
Molar Conductance ◽  
Bacterial Strains ◽  
Vis Spectroscopy

New [ML2(H2O)2] complexes, where M = Co(II), Ni(II), Cu(II), and Zn(II) while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehydein situin the presence of divalent metal salts in ethanolic medium. The complexes were characterized by elemental analyses, conductance, and magnetic measurements, as well as by IR and UV-Vis spectroscopy. The low values of the molar conductance indicate nonelectrolyte type of complexes. Based on spectral data and magnetic moments, an octahedral geometry may be proposed for Co(II), Ni(II), and Zn(II) complexes while a tetragonal geometry for Cu(II) complex. Molecular structure of the Schiff base ligand and its complexes were studied using programs dedicated to chemical modeling and quantomolecular calculation of chemical properties. All the synthesized complexes were tested forin vitroantibacterial activity against some pathogenic bacterial strains, namelyEscherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis,andStaphylococcus aureus. The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.

scholarly journals Synthesis, Characterization and in vitro Antifungal Screening of Manganese(II) and Copper(II) Complexes of Hexaaza [N6] Macrocyclic Ligand

1970 ◽  
Vol 25 ◽  
pp. 46-52
Author(s):  
U. Kumar ◽  
S. Chandra
Keyword(s):  
Metal Ion ◽  
Hyperfine Splitting ◽  
Macrocyclic Ligand ◽  
Chemical Society ◽  
Molar Conductance ◽  
Epr Spectra ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
G Value

New manganese(II) and copper(II) complexes of 12-membered macrocyclic Schiffbase ligand containing thiosemicarbazone moiety have been prepared of generalcomposition [MLX2] where M = Mn(II) or Cu(II), L = 3,4,9,10–tetra-2-furanyl-1,2,5,6,8,11-hexaazacyclododeca-7,12-dithione-2,4,8,10–tetraene, X = Cl-, NO3- and NCS-. Thecomplexes have been characterized by elemental analysis, molar conductance, magneticsusceptibility measurements and spectral (IR, electronic, EPR and mass) analyses. The IRspectra of complexes suggested that ligand is coordinated to the metal ion through iminenitrogen atoms. On the basis of spectral studies, an octahedral and tetragonal geometry hasbeen assigned for Mn(II) and Cu(II) complexes, respectively. EPR spectra of polycrystallineMn(II) complexes gave an isotropic signal with g value centered around free electron gvalue. EPR spectra of Mn(II) complexes in DMSO showed hyperfine splitting containing sixlines, whereas EPR spectra of polycrystatalline Cu(II) complexes showed anisotropicsignal. Conductivity measurements support the non electrolytic nature of the complexes.Magnetic moment data suggest that reported complexes are paramagnetic and of high spintype. All the examined complexes have also been tested in vitro against a number ofpathogenic fungi. Results indicated that the complexes exhibited good antifungal activities.Keywords: Macrocyclic, octahedral, antifungal, tetragonal, anisotropic.DOI:  10.3126/jncs.v25i0.3284Journal of Nepal Chemical Society Volume 25, 2010 pp 46-52

scholarly journals Spectroscopic and biological approach in the characterization of Cr(III), Mn(II) and Co(II) complexes with a novel hexaazamacrocyclic ligand derived from semicarbazide

2009 ◽  
Vol 74 (12) ◽  
pp. 1413-1422 ◽  
Author(s):  
Sulekh Chandra ◽  
Archana Gautam
Keyword(s):  
Antimicrobial Agents ◽  
Macrocyclic Ligand ◽  
Free Ligand ◽  
Pathogenic Fungi ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Plant Pathogenic Fungi

Complexes of Cr(III), Mn(II) and Co(II) with a novel 5,7,12,14-tetraphenyl- 1,2,4,8,10,11-hexaazacyclotetradecane-3,9-dione macrocyclic ligand, THTD (L), were synthesized and characterized by elemental analysis, molar conductance and magnetic susceptibility measurements, as well as by mass, 1H-NMR, IR, electronic and EPR spectral studies. Based on the spectral studies, an octahedral geometry was assigned for the Cr(III), Mn(II) and Co(II) complexes. The ligand and its complexes were screened in vitro against some species of bacteria and plant pathogenic fungi. The metal complexes were found to be more active antimicrobial agents than the free ligand from which they were derived.

scholarly journals Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
K. Savithri ◽  
H. D. Revanasiddappa
Keyword(s):  
Dna Binding ◽  
Mixed Ligand Complex ◽  
Radical Scavenging ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Binding Studies ◽  
Ligand Complex ◽  
Intercalative Mode

Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies. Based on the spectral studies, the complexes have the general composition [VO(L)2] (C1) and [VO(L)phen] (C2) in a square pyramid geometrical fashion. The synthesized compounds were primarily screened for their in vitro growth inhibiting activity against different strains of bacteria, namely, E. coli, B. subtilis, S. aureus, and P. aeruginosa by the disc diffusion method. Also, the antifungal activity was determined against C. albicans and A. niger by the Bateman poisoned technique. The in vitro antioxidant activity of all the compounds was determined by DPPH free radical-scavenging assay. Intercalative mode of DNA-binding properties of the oxidovanadium(IV) complexes with calf-thymus DNA (CT-DNA) was investigated using UV, fluorescence spectra, and viscosity measurements.

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