Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-pyran-2-one

The solid complexes of Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-methyl-2H-pyran-2-one, derived from 3-acetyl-6-methyl-2H-pyran- 2,4(3H)-dione (dehydroacetic acid) and 4-hydroxy benzaldehyde, were synthesized and characterized by elemental analysis, conductometry, thermal analysis, magnetic measurements, IR, 1H-NMR and UV-VIS spectroscopy and a biological study. From the analytical and spectral data, the stoichiometry of the complexes was found to be 1:2 (metal:ligand). The physico-chemical data suggest a distorted octahedral geometry for the Cu(II) complexes and an octahedral geometry for all the other complexes. The thermal decomposition of all the complexes was studied by the TG- DTA method. The synthesized ligand and its metal complexes were screened for their in vitro antibacterial activity against Gram negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Aspergillus flavus, Curvularia lunata and Penicillium notatum. The results of these studies showed the metal complexes to be more antibacterial/antifungal against one or more species as compared with the non-complexed ligand.

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Template synthesis and characterization of biologically active transition metal complexes comprising 14-membered tetraazamacrocyclic ligand

Journal of the Serbian Chemical Society ◽

10.2298/jsc1002217s ◽

2010 ◽

Vol 75 (2) ◽

pp. 217-228 ◽

Cited By ~ 8

Author(s):

Dharmpal Singh ◽

Krishan Kumar ◽

Ramesh Kumar ◽

Jitender Singh

Keyword(s):

Magnetic Measurements ◽

Macrocyclic Ligand ◽

Salmonella Typhi ◽

Molar Conductance ◽

Biologically Active ◽

Distorted Octahedral Geometry ◽

Bacterial Strains ◽

In Vitro Antibacterial Activity ◽

Active Transition

A novel series of complexes of the type [M(C28H24N4)X2], where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X = Cl-, NO3 -, CH3COO- and (C28H24N4) corresponds to the tetradentate macrocyclic ligand, were synthesized by template condensation of 1,8-diaminonaphthalene and diacetyl in the presence of divalent metal salts in methanolic medium. The complexes were characterized by elemental analyses, conductance and magnetic measurements, as well as by UV/Vis, NMR, IR and MS spectroscopy. The low values of the molar conductance indicate non-electrolyte type of complexes. Based on these spectral data, a distorted octahedral geometry may be proposed for all of these complexes. All the synthesized macrocyclic complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, viz Bacillus cereus, Salmonella typhi, Escherichia coli and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains were compared with the MIC shown by the standard antibiotics linezolid and cefaclor.

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Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies

Bioinorganic Chemistry and Applications ◽

10.1155/2014/926287 ◽

2014 ◽

Vol 2014 ◽

pp. 1-17 ◽

Cited By ~ 11

Author(s):

Aurora Reiss ◽

Mariana Carmen Chifiriuc ◽

Emilia Amzoiu ◽

Cezar Ionuţ Spînu

Keyword(s):

Antibacterial Activity ◽

Schiff Base ◽

Schiff Base Ligand ◽

Magnetic Measurements ◽

Magnetic Moments ◽

Chemical Properties ◽

Molar Conductance ◽

Bacterial Strains ◽

Vis Spectroscopy

New [ML2(H2O)2] complexes, where M = Co(II), Ni(II), Cu(II), and Zn(II) while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehydein situin the presence of divalent metal salts in ethanolic medium. The complexes were characterized by elemental analyses, conductance, and magnetic measurements, as well as by IR and UV-Vis spectroscopy. The low values of the molar conductance indicate nonelectrolyte type of complexes. Based on spectral data and magnetic moments, an octahedral geometry may be proposed for Co(II), Ni(II), and Zn(II) complexes while a tetragonal geometry for Cu(II) complex. Molecular structure of the Schiff base ligand and its complexes were studied using programs dedicated to chemical modeling and quantomolecular calculation of chemical properties. All the synthesized complexes were tested forin vitroantibacterial activity against some pathogenic bacterial strains, namelyEscherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis,andStaphylococcus aureus. The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.

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Synthesis and characterization of divalent metal complexes of the macrocyclic ligand derived from isatin and 1,2- diaminobenzene

Journal of the Serbian Chemical Society ◽

10.2298/jsc100607034s ◽

2011 ◽

Vol 76 (3) ◽

pp. 385-393 ◽

Cited By ~ 6

Author(s):

Pal Singh ◽

Vidhi Grover ◽

Krishan Kumar ◽

Kiran Jain

Keyword(s):

Magnetic Measurements ◽

Macrocyclic Ligand ◽

Far Infrared ◽

Antibacterial Activities ◽

Molar Conductance ◽

Spectral Studies ◽

Distorted Octahedral Geometry ◽

Bacterial Strains ◽

Infrared Spectral

A novel series of complexes of the type [M(C28H18N6)X2], where M=Co(II), Ni(II), Cu(II) or Zn(II) and X=Cl-, NO3- or CH3COO-, were synthesized by template condensation of isatin and 1,2-diaminobenzene in methanolic medium. The complexes were characterized with the help of various physico-chemical techniques, such as elemental analyses, molar conductance measurements, magnetic measurements, and NMR, infrared and far infrared spectral studies. The low value of molar conductance indicates them to be non-electrolytes. Based on various studies, a distorted octahedral geometry may be proposed for all the complexes. All the synthesized macrocyclic complexes were also tested for their in vitro antibacterial activity against some pathogenic bacterial strains. The MIC values shown by the complexes against these bacterial strains were compared with those of the standard antibiotics linezolid and cefaclor. Some of the complexes showed good antibacterial activities.

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Transition metal complexes with oxygen donor ligands: A synthesis, spectral, thermal and antimicrobial study

Journal of the Serbian Chemical Society ◽

10.2298/jsc0811073p ◽

2008 ◽

Vol 73 (11) ◽

pp. 1073-1082 ◽

Cited By ~ 9

Author(s):

Vaibhav Patange ◽

Rajendra Pardeshi ◽

Balasaheb Arbad

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Magnetic Measurements ◽

Molar Conductance ◽

Donor Ligands ◽

Curvularia Lunata ◽

Dehydroacetic Acid ◽

Oxygen Donor ◽

Vis Spectroscopy

Transition metal complexes of chalcones derived from the condensation of 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione (dehydroacetic acid) and p-methoxybenzaldehyde (HL1) or p-nitrobenzaldehyde (HL2) were synthesized and characterized by elemental analysis, conductometry, thermal analysis, magnetic measurements, IR, 1H-NMR, UV-Vis spectroscopy and a microbial study. From the analytical and thermal data, the stoichiometry of the complexes was found to be 1:2 (metal: ligand). The molar conductance data revealed that all the metal chelates were non-electrolytes. The thermal stability of the complexes was studied by thermogravimetry and the decomposition schemes of the complexes are given. The ligands and their metal complexes were screened for antibacterial activity against Staphylococcus aureus and Escherichia coli, and fungicidal activity against Aspergillus flavus, Curvularia lunata and Penicillium notatum.

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Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

Frontiers in Chemistry ◽

10.3389/fchem.2021.644691 ◽

2021 ◽

Vol 9 ◽

Author(s):

Abeer A Sharfalddin ◽

Abdul-Hamid Emwas ◽

Mariusz Jaremko ◽

Mostafa A. Hussien

Keyword(s):

Molecular Docking ◽

Metal Complexes ◽

Anticancer Agents ◽

Metal Ion ◽

Interaction Strength ◽

Breast Cancer Cell Lines ◽

Docking Simulations ◽

Biological Studies ◽

Vis Spectroscopy

In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized. The chemical structure of each complex was characterized using elemental analysis (CHN), IR spectroscopy, UV–Vis spectroscopy, thermogravimetric analysis (TGA), and electronic paramagnetic resonance (EPR) spectroscopy. IR spectra indicated that the donor atoms were one sulfonyl oxygen atom and one pyrazine nitrogen atom, which associated with the metal ions to form a stable hexagonal coordination ring. The metal–ligand stability constant (Kf) revealed that Cu(II) and Ni(II) have good coordination stability among the metal compounds. Theoretical studies using DFT/B3LYP were performed to further validate the proposed structures. The obtained results indicated that Cu(II) has a trigonal bipyramidal geometry, whereas Fe(II), Co(II), and Ni(II) have an octahedral structure, while Zn(II) has a tetrahedral arrangement. The bio-activities of the characterized complexes were evaluated using DNA binding titration and molecular docking. The binding constant values for the metal complexes were promising, with a maximum value for the copper metal ion complex, which was 9 × 105 M-1. Molecular docking simulations were also carried out to evaluate the interaction strength and properties of the synthesized metal complexes with both DNA and selected cancer-relevant proteins. These results were supported by in vitro cytotoxicity assays showing that the Cu(II) and Ni(II) complexes display promising antitumor activity against colon and breast cancer cell lines.

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Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes

Materials ◽

10.3390/ma14143854 ◽

2021 ◽

Vol 14 (14) ◽

pp. 3854

Author(s):

Joanna Czechowska ◽

Ewelina Cichoń ◽

Anna Belcarz ◽

Anna Ślósarczyk ◽

Aneta Zima

Keyword(s):

Gold Nanoparticles ◽

Antibacterial Activity ◽

Tricalcium Phosphate ◽

Setting Time ◽

Antibacterial Properties ◽

Bone Substitutes ◽

Bacterial Strains ◽

Setting Times ◽

Biological Studies

Bioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-modified and modified with gold nanoparticles (AuNPs), were designed. The developed biomicroconcretes were supposed to combine the dual functions of antibacterial activity and bone defect repair. The chemical and phase composition, microstructure, setting times, mechanical strength, and in vitro bioactive potential of the composites were examined. Furthermore, on the basis of the American Association of Textile Chemists and Colorists test (AATCC 100), adapted for chemically bonded materials, the antibacterial activity of the biomicroconcretes against S. epidermidis, E. coli, and S. aureus was evaluated. All biomicroconcretes were surgically handy and revealed good adhesion between the hybrid granules and calcium phosphate-based matrix. Furthermore, they possessed acceptable setting times and mechanical properties. It has been stated that materials containing AuNPs set faster and possess a slightly higher compressive strength (3.4 ± 0.7 MPa). The modification of αTCP with silicon led to a favorable decrease of the final setting time to 10 min. Furthermore, it has been shown that materials modified with AuNPs and silicon possessed an enhanced bioactivity. The antibacterial properties of all of the developed biomicroconcretes against the tested bacterial strains due to the presence of both chitosan and Au were confirmed. The material modified simultaneously with AuNPs and silicon seems to be the most promising candidate for further biological studies.

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PHYTO-MEDIATED SYNTHESIS OF SILVER NANOPARTICLES USING AQUEOUS EXTRACT OF „BUGLOSSOIDES PURPUROCAERULEA“ (BORAGINACEAE) AND THEIR BIOACTIVITY

10.46793/iccbi21.359ks ◽

2021 ◽

Author(s):

Jelena S. Katanić Stanković ◽

◽

Nikola Srećković ◽

Vladimir Mihailović

Keyword(s):

Silver Nanoparticles ◽

Aqueous Extract ◽

Radical Scavenging ◽

Antimicrobial Properties ◽

Bacterial Strains ◽

Penicillium Species ◽

Microdilution Method ◽

Biological Potential ◽

Vis Spectroscopy

In this study, silver nanoparticles (AgNPs) have been synthesized using the aqueous extract of the aerial parts of B. purpurocaerulea, collected in Serbia. B. purpurocaerulea silver nanoparticles (Bp– AgNPs) synthesis was confirmed using UV-Vis spectroscopy and Fourier Transform Infrared Spectroscopy (FTIR). The biological potential of synthesized Bp-AgNPs was evaluated in vitro using ABTS assay for determining free radical scavenging potential and microdilution method for analysis of antimicrobial properties. Bp-AgNPs showed high antioxidant activity similar to Bp-extract, comparable to BHT. The synthesized nanoparticles exerted remarkable antibacterial effects, with minimal inhibitory concentration (MIC) values below 20 µg/mL. In the case of some bacterial strains, the results of Bp– AgNPs were comparable or similar to standard antibiotic erythromycin. The antifungal activity of Bp– AgNPs was moderate for most of the used strains. Nevertheless, several fungi were resistant to the NPs action, while two tested Penicillium species were extremely sensitive on Bp-AgNPs with MIC lower than 40 µg/mL. The antimicrobial properties of Bp-AgNPs can be useful for the development of new NPs-containing products.

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Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

International Journal of Spectroscopy ◽

10.1155/2018/8759372 ◽

2018 ◽

Vol 2018 ◽

pp. 1-15 ◽

Cited By ~ 8

Author(s):

K. Savithri ◽

B. C. Vasantha Kumar ◽

H. K. Vivek ◽

H. D. Revanasiddappa

Keyword(s):

Metal Complexes ◽

Antimicrobial Activities ◽

Spectroscopic Studies ◽

Docking Studies ◽

Bacterial Strains ◽

Spectral Techniques ◽

Light Reduction ◽

Drug Candidates ◽

Ft Ir

A bidentate (N- and O-) imine-based ligand (L1) and its metal complexes of types [CuII(L1)2] (C1), [CuII(L1)(Phen)] (C2), [CoIII(L1)2] (C3), and [CoIII(L1)(Phen)] (C4) (L1 = 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes. In vitro bioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus- (CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively by Kb and Ksv values which revealed a higher binding affinity for C2 and C4 as compared to C1 and C3. In addition, the scavenging superoxide anion free radical (O∙-2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used.

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Synthesis, characterization and application of green seaweed mediated silver nanoparticles (AgNPs) as antibacterial agents for water disinfection

Water Science & Technology ◽

10.2166/wst.2018.292 ◽

2018 ◽

Vol 78 (1) ◽

pp. 235-246 ◽

Cited By ~ 7

Author(s):

D. Dixit ◽

D. Gangadharan ◽

K. M. Popat ◽

C. R. K. Reddy ◽

M. Trivedi ◽

...

Keyword(s):

Electron Microscopy ◽

Silver Nanoparticles ◽

Inductively Coupled Plasma ◽

Antibacterial Agents ◽

Bacterial Count ◽

Water Disinfection ◽

Bacterial Strains ◽

Vis Spectroscopy ◽

Green Seaweed

Abstract A simple and eco-friendly method for the synthesis of hybrid bead silver nanoparticles (AgNPs) employing the aqueous extract derived from natural and renewable source namely tropical benthic green seaweed Ulva flexuosa was developed. This route involves the reduction of Ag+ ions anchored onto macro porous methacrylic acid copolymer beads to AgNPs for employing them as antibacterial agents for in vitro water disinfection. The seaweed extract itself acts as a reducing and stabilizing agent and requires no additional surfactant or capping agent for forming the AgNPs. The nanoparticles were analyzed using high-resolution transmission electron microscopy, UV–Vis spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray analysis and inductively coupled plasma optical emission spectroscopy. The study elucidates that such biologically synthesized AgNPs exhibit potential antibacterial activity against two Gram positive (Bacillus subtilis, Staphylococcus aureus) and two Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strains tested. The bacterial count in treated water was reduced to zero for all the strains. Atomic force microscopy was performed to confirm the pre- and post-state of the bacteria with reference to their treatment with AgNPs. Attributes like facile environment-friendly procedure, stability and high antibacterial potency propel the consideration of these AgNPs as promising antibacterial entities.

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Biological Study of Transition Metal Complexes with Adenine Ligand

Proceedings ◽

10.3390/ecsoc-23-06601 ◽

2019 ◽

Vol 41 (1) ◽

pp. 77 ◽

Cited By ~ 1

Author(s):

Hamad M. I. Hasan ◽

Aaza I. Yahiya ◽

Safaa S. Hassan ◽

Mabrouk M. Salama

Keyword(s):

Metal Complexes ◽

Molar Conductance ◽

Molar Ratio ◽

Biological Study ◽

Ratio Method ◽

Spectroscopic Techniques ◽

Stoichiometric Ratio ◽

Metal Contents ◽

Molar Ratio Method

Adenine complexes were prepared with some of the first series transition metals in a stoichiometric ratio of 1: 2 (Mn+: L), where Mn+ = Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, and Cd2+ ions. The Complexes were characterized by the physicochemical and spectroscopic techniques as electric conductivity, metal contents, IR, UV–Visible, and molar conductance techniques. The stoichiometric ratios of the synthesized complexes were confirmed by using molar ratio method. The dissociation constant of adenine ligand was determined spectrophotometrically. Solvent effect on the electronic spectra of the adenine ligand was examined using solvents with different polarities. The biological activity of adenine ligand and its metal complexes were tested in vitro against some selected species of fungi and bacteria. The results showed a satisfactory spectrum against the tested organisms.

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