scholarly journals Synthesis, Characterization, and Biological Activity ofN′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jonnie N. Asegbeloyin ◽  
Oguejiofo T. Ujam ◽  
Emmanuel C. Okafor ◽  
Ilknur Babahan ◽  
Esin Poyrazoglu Coban ◽  
...  
Keyword(s):  
Magnetic Measurements ◽  
Structure Study ◽  
Molar Conductance ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
X Ray ◽  
Gram Positive Bacteria

Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gaveN′-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL1), which was characterized by NMR spectroscopy and single-crystal X-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. The reaction of HL1with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies. The compounds were screened for theirin vitrocytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. Results showed that the compounds are potent against HL-60 cells with the IC50value ≤5 μM, while some of the compounds were active against few studied Gram-positive bacteria.

scholarly journals Synthesis, Characterization and Antibacterial Activities of New Bivalent Complexes of Transition Metals

2019 ◽  
Vol 31 (9) ◽  
pp. 1926-1930
Author(s):  
Veenu Chugh ◽  
Sangeeta Sharma ◽  
Rimpi Mehani Ne'e Chopra
Keyword(s):  
Magnetic Measurements ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Gram Positive Bacteria ◽  
Diffusion Technique ◽  
Complexes Of Transition Metals ◽  
Thermal Stability Of

This paper describes the synthesis, spectral studies and antimicrobial properties of the complexes with the formula [M(C30H24N4O2)Cl2], where M = Fe(II), Co(II), Ni(II), Zn(II) and Cu(II). These complexes were prepared by yield effective template condensation of hexamethylenediamine and 2,2-dihydroxyindane-1,3-dione(ninhydrin). The synthesized complexes were characterized by elemental analysis, infrared spectra, thermogravimetric analysis, Mass spectrum, 13C NMR, molar conductance, electronic spectra, magnetic measurements. TGA and X-ray diffraction studies were used to ascertain the crystal structure and thermal stability of the complexes. The antimicrobial properties of complexes against two Gram-positive bacteria and two Gram-negative bacteria were evaluated by Agar well diffusion technique. Streptomycin and chloramphenicol were taken as standard antibiotics. The results shows that some of the complexes have potential to act as antibacterial agents.

Antiferromagnetic super exchange and spectral studies on dimeric 8-quinolinolato complexes of copper(II) imides

1985 ◽  
Vol 63 (11) ◽  
pp. 3027-3030 ◽  
Author(s):  
C. L. Sharma ◽  
V. Mishra
Keyword(s):  
Magnetic Measurements ◽  
Spectral Studies ◽  
Mass Determination ◽  
X Ray Diffraction ◽  
X Ray ◽  
Susceptibility Data ◽  
Dimeric Unit ◽  
Square Planar ◽  
Different Temperatures ◽  
Super Exchange Interaction

The complexes of the type [Cu(Q)(P)]2 and [Cu(Q)(S)]2 where HQ = 8-hydroxyquinoline and P and S are deprotonated phthalimide and succinimide, respectively, were prepared and characterized on the basis of molecular mass determination, elemental analysis. X-ray diffraction, ir, electronic spectra, conductance, thermal analysis, and magnetic measurements. They were of tetrahedrally distorted square planar structure. The susceptibility data at different temperatures were fitted to the Bleaney–Bowers equation which indicated medium antiferromagnetic super exchange interaction within one dimeric unit. The values of exchange integral and g were found to be −136 cm−1 and 2.18, respectively, for the phthalimide complex and −128 cm−1 and 2.16, respectively, for the succinimide complex.

scholarly journals Synthesis and spectroscopic characterization of some lanthanide(III) nitrate complexes of 3-[3-carboxyethyl-4,5- dimethylthiophene-2-yl)azo]pent-2,4-dione

2011 ◽  
Vol 76 (2) ◽  
pp. 249-261 ◽  
Author(s):  
Janardhanan Athira ◽  
Yesodharan Sindhu ◽  
Susamma Sujamol ◽  
Kochukittan Mohanan
Keyword(s):  
Elemental Analysis ◽  
Metal Ion ◽  
Spectroscopic Characterization ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Structural Form ◽  
X Ray Diffraction ◽  
X Ray ◽  
Nitrate Complexes

3-[3-Carboxyethyl-4,5-dimethylthiophene-2-yl)azo]pent-2,4-dione was synthesized by coupling diazotized 2-amino-3-carboxyethyl- 4,5-dimethylthiophene with acetylacetone. Based on various spectral studies and elemental analysis, an intramolecularly hydrogen bonded azoenol structural form was assigned for the ligand. This ligand is versatile in forming a series of lanthanide(III) complexes viz, lanthanum(III), cerium(III), praseodymium(III), neodymium(III), samarium(III) and gadolinium(III), which were characterized through various spectral studies, elemental analysis, magnetic susceptibility measurements, molar conductance and thermal analysis. The spectral data revealed that the ligand acted as a neutral tridentate, coordinating to the metal ion through one of the azo nitrogen atoms, the ester carbonyl and the enolic oxygen of the acetylacetone moiety, without deprotonation. Molar conductance values adequately supported their non-electrolytic nature. The ligand and lanthanum(III) complexes were subjected to X-ray diffraction studies. In addition, the lanthanum(III) complex underwent a facile transesterification reaction on refluxing with methanol for a long period. The thermal behavior of the lanthanum(III) complex was also examined.

scholarly journals In Vitro Studies of the Antimicrobial and Free-Radical Scavenging Potentials of Silver Nanoparticles Biosynthesized From the Extract of Desmostachya bipinnata

2018 ◽  
Vol 13 ◽  
pp. 117739011878287 ◽  
Author(s):  
Sitaramanjaneya Reddy Guntur ◽  
NS Sampath Kumar ◽  
Manasa M Hegde ◽  
Vijaya R Dirisala
Keyword(s):  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Radical Scavenging ◽  
X Ray Diffraction ◽  
X Ray ◽  
Gram Positive Bacteria ◽  
Antimicrobial Studies ◽  
Hepg2 Cell Lines ◽  
Hydrazyl Radical

The aim of this study was to perform green synthesis of silver nanoparticles (AgNPs) from the leaf extract of Desmostachya bipinnata (Dharba), a medicinally important herb which is widely used across India. Synthesized AgNPs were analyzed by UV-Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDAX). The results have confirmed that green synthesis of AgNPs leads to the fabrication of sphere-shaped particles with a diameter of 53 nm. Furthermore, these AgNPs were subjected to antioxidant and antimicrobial studies against gram-negative and gram-positive bacteria, where AgNPs at a concentration of 20 mg/mL showed highest zone of inhibition. Synthesized AgNPs were evaluated for their antioxidant activity by 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH), H2O2, and superoxide inhibiting assays; increasing concentration has showed increase in scavenging ability. Cell toxicity was assessed on HepG2 cell lines, and synthesized nanoparticles at a concentration of 128 μg/mL produced significant reduction in viability of Hep cells ( P < .05). The availability of Dharba throughout the year and the eco-friendly approach in the synthesis of AgNPs coupled with bioactivity has demonstrated its potential as a novel biomaterial which can be used for various biomedical applications.

scholarly journals Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil

1998 ◽  
Vol 5 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Udai P. Singh ◽  
Sudha Singh ◽  
Sukh Mahendra Singh
Keyword(s):  
Metal Complexes ◽  
Room Temperature ◽  
Magnetic Measurements ◽  
Antitumour Activity ◽  
Tumour Cells ◽  
Sarcoma 180 ◽  
X Ray Diffraction ◽  
X Ray

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.

scholarly journals Synthesis and characterization of divalent metal complexes of the macrocyclic ligand derived from isatin and 1,2- diaminobenzene

2011 ◽  
Vol 76 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Pal Singh ◽  
Vidhi Grover ◽  
Krishan Kumar ◽  
Kiran Jain
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Far Infrared ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
Infrared Spectral

A novel series of complexes of the type [M(C28H18N6)X2], where M=Co(II), Ni(II), Cu(II) or Zn(II) and X=Cl-, NO3- or CH3COO-, were synthesized by template condensation of isatin and 1,2-diaminobenzene in methanolic medium. The complexes were characterized with the help of various physico-chemical techniques, such as elemental analyses, molar conductance measurements, magnetic measurements, and NMR, infrared and far infrared spectral studies. The low value of molar conductance indicates them to be non-electrolytes. Based on various studies, a distorted octahedral geometry may be proposed for all the complexes. All the synthesized macrocyclic complexes were also tested for their in vitro antibacterial activity against some pathogenic bacterial strains. The MIC values shown by the complexes against these bacterial strains were compared with those of the standard antibiotics linezolid and cefaclor. Some of the complexes showed good antibacterial activities.

scholarly journals Synthesis, characterization and antibacterial activity of Methyl (2R)-2-benzamido-2-{[(1R)-2-methoxy-2-oxo- 1-phenylethyl]amino}acetate

2018 ◽  
Vol 7 (4) ◽  
pp. 267-271
Author(s):  
Oumaima Karai ◽  
Younas Aouine ◽  
Hassane Faraj ◽  
Alami Anouar ◽  
Mohammed Rachid Kabbour ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Methylene Chloride ◽  
Bactericidal Effect ◽  
Gram Negative Bacteria ◽  
X Ray Diffraction ◽  
Prepared Compound ◽  
X Ray ◽  
Gram Positive Bacteria ◽  
And Staphylococcus Aureus

The present work covers the recent synthetic of methyl (2R)-2-benzamido-2-{[(1R)-2-methoxy-2-oxo-1-phenylethyl]amino}acetate, via N-alkylation of methyl a-azido glycinate N-benzoylated with methyl 2-amino-2-phenylacetate in methylene chloride and in presence of triethylamine as basic catalyst. The structure of the prepared compound was determined by spectroscopic methods: 1H-NMR, 13C-NMR, MS data, elemental analysis and confirmed by X-Ray diffraction. This compound was screened in vitro for its antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella enteric). The MIC values confirmed that the title compound had a bactericidal effect against the strains tested.

Synthesis, Spectral and Antimicrobial Investigation of 2-(Naphthalenel-ylamino)-2- Phenylacetonitrile and 1, 10-Phenanthroline with Five Divalent Transition Metal Ions

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Mohammed Al-Amery1 ◽  
Ashraf Saad Rasheed ◽  
Dina A. Najeeb
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Gram Negative Bacteria ◽  
Magnetic Studies ◽  
Gram Positive Bacteria

Five new mixed ligand metal complexes have been synthesized by the reaction of divalent transition metal ions (Hg, Ni, Zn, Cu and Cd) with 2-(naphthalen-l-ylamino)-2-phenylacetonitrile (L1 ) and 1,10-phenanthroline (L2). The coordination likelihood of the two ligands toward metal ions has been suggested in the light of elemental analysis, UV-Vis spectra, FTIR, 1H-NMR, flam atomic absorption, molar conductance and magnetic studies. Results data suggest that the octahedral geometry for all the prepared complexes. Antibacterial examination of synthesized complexes in vitro was performed against four bacterias. Firstly, Gram-negative bacteria namely, Pseudomonas aerugin and Escherichia. Secondly, Gram-positive bacteria namely, Bacillus subtilis, Staphylococcuaurouss. Results data exhibit that the synthesized complexes exhibited more biological activity than tetracycline pharmaceutical.

scholarly journals Template synthesis and characterization of biologically active transition metal complexes comprising 14-membered tetraazamacrocyclic ligand

2010 ◽  
Vol 75 (2) ◽  
pp. 217-228 ◽  
Author(s):  
Dharmpal Singh ◽  
Krishan Kumar ◽  
Ramesh Kumar ◽  
Jitender Singh
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Salmonella Typhi ◽  
Molar Conductance ◽  
Biologically Active ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
In Vitro Antibacterial Activity ◽  
Active Transition

A novel series of complexes of the type [M(C28H24N4)X2], where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X = Cl-, NO3 -, CH3COO- and (C28H24N4) corresponds to the tetradentate macrocyclic ligand, were synthesized by template condensation of 1,8-diaminonaphthalene and diacetyl in the presence of divalent metal salts in methanolic medium. The complexes were characterized by elemental analyses, conductance and magnetic measurements, as well as by UV/Vis, NMR, IR and MS spectroscopy. The low values of the molar conductance indicate non-electrolyte type of complexes. Based on these spectral data, a distorted octahedral geometry may be proposed for all of these complexes. All the synthesized macrocyclic complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, viz Bacillus cereus, Salmonella typhi, Escherichia coli and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains were compared with the MIC shown by the standard antibiotics linezolid and cefaclor.

A study on using expanded perlite with hydroxyapatite: Reinforced bio-composites

2021 ◽  
pp. 095441192199656
Author(s):  
Erdoğan Karip ◽  
Mehtap Muratoğlu
Keyword(s):  
Body Fluid ◽  
Xrd Analysis ◽  
Cold Isostatic Pressing ◽  
Expanded Perlite ◽  
X Ray Diffraction ◽  
Pressing Method ◽  
X Ray ◽  
Infra Red ◽  
Ft Ir

People are exposed to different kinds of diseases or various accidents in life. Hydroxyapatite (HA) has been widely employed for bone treatment applications. In this study, HA was extracted from sheep bones. Bio-composites were doped with 1, 5, and 10 wt.% of expanded perlite and 5 wt.% of ZrO2–MgO-P2O5. The bio-composites were prepared by the cold isostatic pressing method (250 MPa) and sintered at 900°C for 1 h. In order to evaluate the characteristics of the bio-composites, microhardness, density, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) analyses were carried out on them. Additionally, the specimens whose characteristics were determined were kept in synthetic body fluid (SBF), and their in vitro behavior was examined. As a result, it was observed that microhardness increased as both the weight and the grain size of the expanded perlite were increased. Calcium silicate, tri-calcium phosphate, and hydroxyapatite were observed in the XRD analysis of all samples, and the formation of apatite structures was increased by addition of ZrO2–MgO–P2O5.

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