scholarly journals Spectroscopic and biological approach in the characterization of Cr(III), Mn(II) and Co(II) complexes with a novel hexaazamacrocyclic ligand derived from semicarbazide

2009 ◽  
Vol 74 (12) ◽  
pp. 1413-1422 ◽  
Author(s):  
Sulekh Chandra ◽  
Archana Gautam
Keyword(s):  
Antimicrobial Agents ◽  
Macrocyclic Ligand ◽  
Free Ligand ◽  
Pathogenic Fungi ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Plant Pathogenic Fungi

Complexes of Cr(III), Mn(II) and Co(II) with a novel 5,7,12,14-tetraphenyl- 1,2,4,8,10,11-hexaazacyclotetradecane-3,9-dione macrocyclic ligand, THTD (L), were synthesized and characterized by elemental analysis, molar conductance and magnetic susceptibility measurements, as well as by mass, 1H-NMR, IR, electronic and EPR spectral studies. Based on the spectral studies, an octahedral geometry was assigned for the Cr(III), Mn(II) and Co(II) complexes. The ligand and its complexes were screened in vitro against some species of bacteria and plant pathogenic fungi. The metal complexes were found to be more active antimicrobial agents than the free ligand from which they were derived.

scholarly journals Synthesis and Spectral Characterization of Mn(II) and Co(II) Complexes with Tetradentate Macrocyclic Ligand

2021 ◽  
Vol 33 (9) ◽  
pp. 2207-2211
Author(s):  
Usha Bansal ◽  
Samta Goyal ◽  
Swati Agrawal
Keyword(s):  
Metal Complexes ◽  
Infrared Spectra ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Macrocyclic Ligand ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Metal Salts ◽  
Spectral Studies

Manganese(II) and cobalt(II) complexes were synthesized with [N4] tetradentate macrocyclic ligand using different metal salts i.e. MnCl2, Mn(NO3)2, CoCl2 and Co(NCS)2. The ligand was prepared by condensation of glyoxal and carbahydrazide. All these were characterized by elemental analysis, molar conductance measurements, magnetic moment, IR, mass, electronic and EPR spectral studies. Elemental analysis indicates that the complexes have composition MLX2 where (X = Cl–, NO3 –,NCS–). All the complexes were found to be non-electrolytic in nature so can be formulated as [MLX2]. Infrared spectra of metal complexes suggest that the ligand behaves as tetradentate. On the basis of magnetic moment, electronic and EPR spectral data, all the metal complexes were found to be high spin with octahedral geometry.

scholarly journals Synthesis and characterization of a tetraaza macrocyclic ligand and its Cobalt(II), Nickel(II) and Copper(II) complexes

2010 ◽  
Vol 75 (7) ◽  
pp. 935-941 ◽  
Author(s):  
Sulekh Chandra ◽  
Monika Tyagi ◽  
Swati Agarwal
Keyword(s):  
Fungicidal Activity ◽  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Conductance Data ◽  
Square Planar ◽  
Nitrogen Donor ◽  
Elemental Analyses

Co(II), Ni(II), and Cu(II) complexes with a tetradentate nitrogen donor [N4] macrocyclic ligand, viz 1,5,8,13-tetraaza-2,9-dimethyl-4,11- diphenylcyclotetradeca-2,4,4,11-tetraene were synthesized. Their structures were determined based on elemental analyses; molar conductance and magnetic susceptibility measurements; and IR, 1H-NMR (ligand), and electronic spectral studies. Based on analytical and molar conductance data, the complexes may be formulated as [M(L)Cl2] and [M?(L)]Cl2 [where M = Co(II) and Cu(II), and M? = Ni(II)] due to their non-electrolytic and 1:2 electrolytic nature. Based on spectral studies, an octahedral geometry was assigned for the Co(II) complex, whereas square-planar and tetragonal geometry were proposed for the Ni(II) and Cu(II) complexes, respectively. The synthesized ligand and its complexes were screened for fungicidal activity against two pathogenic fungi (i.e., Fusarium. moniliformae and Rhizoctonia solani) to assess their growth inhibiting potential.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Sulekh Chandra ◽  
Smriti Raizada ◽  
Monika Tyagi ◽  
Archana Gautam
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Copper Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Biological Active Cobalt(II) and Nickel(II) Complexes of 12-Membered Hexaaza [N6] Macrocyclic Ligand Synthetic and Spectroscopic Aspects

2010 ◽  
Vol 7 (4) ◽  
pp. 1238-1245 ◽  
Author(s):  
Umendra Kumar ◽  
Sulekh Chandra
Keyword(s):  
Thermal Analysis ◽  
Magnetic Susceptibility ◽  
Metal Ion ◽  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Spectroscopic Studies ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Conductivity Measurements ◽  
Macrocyclic Schiff Base

New cobalt(II) and nickel(II) complexes of 12-membered macrocyclic Schiff - base ligand containing thiosemicarbazone moiety as a part of ring have been prepared having general composition [MLX2] where M = Co(II) or Ni(II), L=3,4,9,10–tetra-2-furanyl-1,2,5,6,8,11- hexaazacyclododeca-7,12- dithione - 2,4,8,10 – tetraene, X = Cl-, NO3-, NCS-. The complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, spectral (IR, electronic, EPR) techniques and thermal analysis. Spectroscopic studies suggested a six coordinated octahedral geometry for all the complexes. The IR spectra of complexes suggest that ligand is coordinated to the metal ion through its four imines nitrogen. Conductivity measurements supported the non electrolytic nature of the complexes. The antifungal activities of complexes have been studied against a number of pathogenic fungi under laboratory conditions. The complexes showed good antifungal results. Thermal analysis of reported complexes suggests the absence of water molecule either in or outside the coordination sphere.

scholarly journals Ni(II), Pd(II) and Pt(II) complexes with ligand containing thiosemicarbazone and semicarbazone moiety: Synthesis, characterization and biological investigation

2008 ◽  
Vol 73 (7) ◽  
pp. 727-734 ◽  
Author(s):  
Sulekh Chandra ◽  
Monika Tyagi
Keyword(s):  
Chelating Agents ◽  
Fungal Species ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Biological Investigation ◽  
Square Planar ◽  
New Compounds

The synthesis of nickel(II), palladium(II) and platinum(II) complexes with thiosemicarbazone and semicarbazone of p-tolualdehyde are reported. All the new compounds were characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, mass, 1H-NMR, IR and electronic spectral studies. Based on the molar conductance measurements in DMSO, the complexes may be formulated as [Ni(L)2Cl2] and [M(L)2]Cl2 (where M = Pd(II) and Pt(II)) due to their non-electrolytic and 1:2 electrolytic nature, respectively. The spectral data are consistent with an octahedral geometry around Ni(II) and a square planar geometry for Pd(II) and Pt(II), in which the ligands act as bidentate chelating agents, coordinated through the nitrogen and sulphur/oxygen atoms. The ligands and their metal complexes were screened in vitro against fungal species Alternaria alternata, Aspergillus niger and Fusarium odum, using the food poison technique. .

scholarly journals Synthesis and characterization of divalent metal complexes of the macrocyclic ligand derived from isatin and 1,2- diaminobenzene

2011 ◽  
Vol 76 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Pal Singh ◽  
Vidhi Grover ◽  
Krishan Kumar ◽  
Kiran Jain
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Far Infrared ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
Infrared Spectral

A novel series of complexes of the type [M(C28H18N6)X2], where M=Co(II), Ni(II), Cu(II) or Zn(II) and X=Cl-, NO3- or CH3COO-, were synthesized by template condensation of isatin and 1,2-diaminobenzene in methanolic medium. The complexes were characterized with the help of various physico-chemical techniques, such as elemental analyses, molar conductance measurements, magnetic measurements, and NMR, infrared and far infrared spectral studies. The low value of molar conductance indicates them to be non-electrolytes. Based on various studies, a distorted octahedral geometry may be proposed for all the complexes. All the synthesized macrocyclic complexes were also tested for their in vitro antibacterial activity against some pathogenic bacterial strains. The MIC values shown by the complexes against these bacterial strains were compared with those of the standard antibiotics linezolid and cefaclor. Some of the complexes showed good antibacterial activities.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine Thiosemicarbazone

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Sulekh Chandra ◽  
Shikha Parmar ◽  
Yatendra Kumar
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Antimicrobial Studies

A series of metal complexes of Zn(II) and Hg(II) having the general composition [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = , and ] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Spectroscopic, thermal and antibacterial studies on Mn(II) and Co(II) complexes derived from thiosemicarbazone

2009 ◽  
Vol 74 (8-9) ◽  
pp. 907-915 ◽  
Author(s):  
Sulekh Chandra ◽  
Monika Tyagi ◽  
Moamen Refat
Keyword(s):  
Magnetic Susceptibility ◽  
Thermogravimetric Analysis ◽  
Metal Complexes ◽  
Thermal Studies ◽  
Free Ligand ◽  
Antibacterial Properties ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Antibacterial Studies

Mn(II) and Co(II) complexes having the general composition [M(L)2X2] (where L = 2-pyridinecarboxaldehyde thiosemicarbazone, M = Mn(II) and Co(II), X = Cl- and - NO3 ) were synthesized. All the metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, mass, IR, EPR, electronic spectral studies and thermogravimetric analysis (TG). Based on the spectral studies, an octahedral geometry was assigned for all the complexes. Thermal studies of the compounds suggest that the complexes are more stable than the free ligand. This fact was supported by the kinetic parameters calculated using the Horowitz-Metzger (H-M) and Coats-Redfern (C-R) equations. The antibacterial properties of the ligand and its metal complexes were also examined and it was observed that the complexes are more potent bactericides than the free ligand.

scholarly journals Synthesis and in silico investigation of Schiff base derivatives of 1H-indole-2,3-diones and their Co(II) and Ni(II) complexes as antimicrobial agents

2019 ◽  
Vol 6 (12) ◽  
pp. 63-85
Author(s):  
Helen O. Echekwube ◽  
Pius O. Ukoha ◽  
Oguejiofo T. Ujam ◽  
Charles O. Nwuche ◽  
Jonnie N. Asegbeloyin ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Binding Modes ◽  
Literature Report ◽  
Protein Targets ◽  
E Coli ◽  
Antimicrobial Studies ◽  
Activity Spectrum

3-[(2-aminophenyl)imino]-1,3-dihydro-2H-indol-2-one, (Lo), 1,3-phenylenediazanylylidene di (1,3-dihydro-2H-indol-2-one), (Lm) and 1,4-phenylenediazanylylidene di(1,3-dihydro-2H-indol-2-one) (Lp) were synthesized by the reaction of 1H-indole-2,3-dione with benzene-1,2-diamine, benzene-1,3-diamine and benzene-1,4-diamine respectively. The reaction of Lo, Lm and Lp with Co(II) and Ni(II) halides gave the corresponding coordination complexes which were characterized by elemental analysis, molar conductance, infra-red, GC-MS and electronic spectral studies. Docking of the 1H-indole-2,3-diones toward the binding sites of penicillin binding protein and DNA gyrase showed they interacted favourably with the test antibacterial targets at deltaGs range of -2.51 to -5.48 kcal/mol. In accordance to literature report, coordination of cobalt and nickel to the ligands yielded metal complexes which exhibited improved interaction with the protein targets (at deltaGs range of -8.70 to -10.20 kcal/mol). In vitro antimicrobial studies against some microorganisms showed that some of the compounds were active against few Gram negative and Gram positive bacteria. The Lo, Lm and Lp had no activity against any of the test microorganisms but the Co(II) and Ni(II) complexes, showed antibacterial activity. The [Co(Lo)2] and [Ni(Lo)2] complexes generated the least antibacterial response. [Co(Lo)2] was ineffective against E. coli 6 and Staphylococcus sciuri subsp sciuri while Bacillus subtilis was resistant to [Ni(Lo)2] which moderately inhibited E. coli 14 (7 mm). Both compounds indicated zero activity against Pseudomonas aeruginosa. The complex that evoked the highest bactericidal activity were [CoLm]Cl2 and [NiLp]Cl2. The antibiogram activity of [CoLm]Cl2 was found between 20 and 30 mm with E. coli 6 displaying greater sensitivity (30 mm) and S. sciuri the least (20 mm). The activity of [NiLp]Cl2 complex indicate that the activity spectrum of the organisms occurred within 29 and 45 mm range; the least sensitive were E. coli 14 (29 mm) and B. subtilis (29 mm) while the most sensitive was S. sciuri subsp sciuri (45 mm). The two compounds were further studied for minimum inhibitory concentration (MIC) and their binding modes towards the studied protein targets were analyzed. Result indicate that the MIC of 1.25 ug/mL was determined for the complex ([NiLp]Cl2) against S. sciuri subsp sciuri (12 mm) while in case of [CoLm]Cl2, the MIC was 2.5 ug/mL (13 mm) against the same organism. The binding modes predicted for [CoLm]Cl2 and [NiLp]Cl2 identified essential residues necessary for interaction with the studied proteins and which could be targeted during structural/activity optimization.

scholarly journals Synthesis and Characterization of Co(II) and Ni(II) complexes of Schiff base derived from Ninhydrin and Valine

2020 ◽  
Vol 13 (3) ◽  
pp. 265-273
Author(s):  
Bekele Yirga ◽  
Achalu Chimdi ◽  
P.Thillai Arasu
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Analytical Data ◽  
Synthesis Method ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Molar Magnetic Susceptibility ◽  
Donor Behavior

In this study, Complexes of Co (II) and Ni (II) ions with Ruhmann’s purple (ligand) were successfully synthesized and characterized. The complexes of NiL2and CoL2were synthesized by using template condensation synthesis method and characterized by melting point, solubility, elemental analysis, and molar conductance, and magnetic susceptibility, infrared and electronic spectral studies. The complexes, NiL2and CoL2 are soluble in ethanol, partially soluble in Diethyl ether and chloroform and insoluble in hexane and petroleum ether. The complexes, NiL2and CoL2 neither melt nor decompose up to 4200C. The molar conductance of NiL2and CoL2 was 42 Scm2/mol and 46Scm2/mol in respectively. The molar magnetic susceptibility of two complexes was 1.74 BM for NiL2 and 2.76 BM for CoL2. The metal to ligand ratio of both metal complexes was 1:2; both metal complexes are non-electrolytes in ethanol and are paramagnetic at 210C. Based on the spectral data and other analytical data, monobasic ONO donor behavior of the ligand (Ruhmann’s purple) generates octahedral geometry for the pink-green colored Ni (II) complex and green colored Co (II) complex.

Sign in / Sign up

Export Citation Format

Share Document