scholarly journals A multidisciplinary approach to the management of gastroenteropancreatic neuroendocrine tumors - a case report

2020 ◽  
Vol 73 (3-4) ◽  
pp. 116-120
Author(s):  
Dijana Kosijer ◽  
Zeljka Savic ◽  
Dragomir Damjanov ◽  
Dimitrije Damjanov ◽  
Djuro Macut ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Multidisciplinary Approach ◽  
Imaging Techniques ◽  
Medical Center ◽  
Endocrine System ◽  
Watery Diarrhea ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Facial Swelling

Introduction. Gastroenteropancreatic neuroendocrine tumors comprise a heterogeneous group of neoplasms that originate from the cells of the diffuse endocrine system within the gastrointestinal tract and pancreas. The diagnostic procedures and therapy of patients with gastroenteropancreatic neuroendocrine tumors is complex and requires a multidisciplinary approach. Case Report. A 51-year-old patient visited a Gastroenterology Outpatient Clinic for examination complaining of redness, facial swelling and frequent watery diarrhea since the age of 48 years. The clinical examination revealed subicterus, systolic murmur, and hepatomegaly. The patient received an extensive examination that included specific laboratory tests and various imaging techniques (endoscopy, radiology, cardiology, nuclear imaging) at the regional medical center. He was referred to a tertiary medical center, including the national Center for the Treatment of Neuroendocrine Tumors, and a metastatic neuroendocrine tumor, most likely affecting the ileum, was established. After preoperative cardiac and anesthesiological assessments, an elective surgical procedure was performed, with a pathohistological/immunohistochemical confirmation of a grade 1 neuroendocrine tumor of the ileum. Conclusion. The process of diagnosing gastroenteropancreatic neuroendocrine tumors, after the onset of symptoms, is often long, associated with comorbidities, and requires a multidisciplinary approach to diagnosis, treatment and monitoring.

Abdominal Manifestations of Neuroendocrine Tumors

2019 ◽  
Vol 03 (01) ◽  
pp. 014-029
Author(s):  
Leonardo Marcal ◽  
Madhavi Patnana ◽  
Sireesha Yedururi ◽  
Hubert Chuang ◽  
Catherine Devine ◽  
...  
Keyword(s):  
Small Bowel ◽  
Neuroendocrine Tumors ◽  
Multidisciplinary Approach ◽  
Imaging Techniques ◽  
Tumor Biology ◽  
Imaging Features ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
New Developments ◽  
Clinical Presentations ◽  
Unites States

AbstractDespite being rare, the incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (NETs) is rising. They are a heterogeneous group of tumors with differences in clinical presentations, genetics, and imaging features. Advances in pathological classification, imaging (including recent radiotracer approval for functional imaging in the Unites States), and therapy have impacted management of these tumors. It is important in the multidisciplinary approach to patient care to be familiar with the tumor biology, imaging techniques for diagnosis and staging, and therapeutic options. This article will discuss these new developments, particularly focusing on pancreatic and small bowel NETs.

scholarly journals Comprehensive Treatment of Mediastinal Neuroendocrine Tumor: A Case Report

2021 ◽  
Author(s):  
Qi Yu ◽  
Zhen Li ◽  
Xinwei Han
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Neuroendocrine Tumors ◽  
Tumor Recurrence ◽  
Transcatheter Arterial Chemoembolization ◽  
Comprehensive Treatment ◽  
Drug Eluting ◽  
Arterial Chemoembolization

Abstract Neuroendocrine tumors in the mediastinum are relatively rare. We report a patient with mediastinal neuroendocrine tumor that was successfully resected after descending stage by drug-eluting embolic transcatheter arterial chemoembolization had been performed. No tumor recurrence was found in the 1-year follow-up after surgical resection.

Neuroendocrine tumor of the periappendicular area of the cecum bottom – a case report

2021 ◽  
Vol 75 (1) ◽  
pp. 68-71
Author(s):  
Lukáš Bača ◽  
Róbert Psár ◽  
Martin Hanousek ◽  
Petr Fojtík
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Enteroendocrine Cells ◽  
Special Group ◽  
Slow Growing

Neuroendocrine tumors are slow-growing neoplasms, histologically based on enteroendocrine cells. They are tumors with different degrees of differentiation, uncertain bio­logical nature and metastatic ability. Their most common localization is the gastrointestinal tract, with a special group of the neuroendocrine tumors of appendix, which are incidentally found after appendectomy. In case report, we would like to present a case of a patient with neuroendocrine tumors of appendix dia­gnosed by colonoscopy.

Imaging and Contrast-enhanced Ultrasound features of duodenal neuroendocrine tumor: A case report

2020 ◽  
Vol 76 (1) ◽  
pp. 27-32
Author(s):  
Yan-Qun Zhang ◽  
Jie-Xian Wen ◽  
Rong-Kui Luo ◽  
Hai-Xia Yuan ◽  
Wen-Ping Wang
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Endocrine Cells ◽  
Contrast Enhanced Ultrasound ◽  
Duodenal Neoplasms ◽  
Contrast Enhanced ◽  
Duodenal Neuroendocrine Tumors ◽  
Ultrasound Features

Duodenal neuroendocrine tumors are rare neoplasms arising from endocrine cells. Here we present a case of 32-year-old woman with Duodenal neuroendocrine tumors, report the imaging and contrast-enhanced Ultrasound (CEUS) features and review previous literatures of neuroendocrine tumors, which may be valuable for the differential diagnosis of duodenal neoplasms.

Gastroenteropancreatic neuroendocrine tumors: clinicopathological evaluation at Shifa International Hospital, Islamabad. A single centre experience

2020 ◽  
pp. 1-14
Author(s):  
Nadira Mamoon ◽  
Hania Naveed ◽  
Mariam Abid ◽  
Humaira Nasir ◽  
Imran Nazir Ahmad ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Neuroendocrine Carcinoma ◽  
World Health ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Single Centre Experience ◽  
Who 2010 Classification ◽  
Well Differentiated ◽  
Grade 3 ◽  
Health Organization

Abstract Objective: Clinicopathological features of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have rarely been studied in the Pakistani population. We investigated the clinical characteristics of these tumors according to the updated World Health Organization (WHO) 2010 classification. Methods: The data of Shifa International Hospital, Islamabad was retrospectively analysed for pathologically confirmed GEP-NETs from January 2013 to March 2018. Results: One hundred and eighteen patients (mean age, 52.2 years; male, 55.1%) were identified. 83.1% of the patients were symptomatic including5.1% functional tumors. Pancreas (28%) was the most frequent primary site noted. The most common histologic type was well differentiated neuroendocrine tumor (WDNET) in 81.4% followed by neuroendocrine carcinoma (NEC) in 16.1%. 45.8% cases of WDNET were grade 1, 27.1% were grade 2, and 8.5% were grade 3.15.3% had distant metastasis at the time of diagnosis with liver (77.7%) as the most common metastatic site. Synaptophysin positivity was seen in 96.8% of grade 1 & grade 2 WDNET, 100% of grade 3 WDNET and 92.3% of NEC and chromogranin was positive in 94.2% of grade 1 &grade 2 WDNET, 83.3% of grade 3 WDNET and 45.4% of NEC. Conclusion: GEP-NETs showed a wide clinicopathological spectrum. Pancreas is the most site of involvement by the GEP-NET however grade 3 WDNET had a predilection for the colon. Small cell carcinomas were commonly observed in esophagus. Keywords: Gastroenteropancreatic neuroendocrine tu­mor, well differentiated neuroendocrine tumor, neuroendocrine carcinoma. Continuous...

scholarly journals Localization of Neuroendrocrine Tumors Using Somatostatin Receptor Imaging with Indium-111-Pentetreotide (OctreoScan)

1997 ◽  
Vol 4 (1) ◽  
pp. 1-3 ◽  
Author(s):  
E. Christopher Ellison ◽  
William J. Schirmer ◽  
John O. Olsen ◽  
Rodney V. Pozderac ◽  
George Hinkle ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Imaging Techniques ◽  
Somatostatin Receptor ◽  
Somatostatin Receptors ◽  
Receptor Imaging ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Primary Tumors ◽  
Duodenal Tumor ◽  
Computed Tomography Scanning ◽  
Indium 111

Background Many imaging methods have been used to detect neuroendocrine tumors of the gastrointestinal system. There is no gold standard for identifying the location of primary tumors and their potential metastases, and most conventional imaging techniques cannot detect tumors less than 1.0 cm in size. Methods The authors have investigated the use of 111In-pentetreotide as an imaging agent for abdominal neuroendocrine tumors. Results The agent is cleared rapidly by the kidneys and is primarily excreted intact with a biologic half-life of six hours. The largest radiation burden is to the spleen and kidneys. A nine-center study conducted in Europe involved 365 patients with gastroenteropancreatic neuroendocrine tumors that were also imaged by other methods. The results of 111In-pentetreotide were in agreement with those obtained by other methods for 79% of tumor locations. An additional 110 tumor localizations were detected that were not seen with conventional methods. The smallest gastrinoma imaged by 111In-pentetreotide was a 4-mm duodenal tumor. Conclusions Scintigraphy with 111In-pentetreotide is effective in visualizing various somatostatin receptors characteristic of neuroendocrine tumors of the gastrointestinal tract. Insulinomas, however, are not well imaged. Concurrent computed tomography scanning is advised to minimize the risk of missing liver metastases.

scholarly journals A Rare Case of Chronic Diarrhea in a Pediatric Patient

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A988-A988
Author(s):  
Priya S Srivastava ◽  
Kevin Yen ◽  
Robert Lindquist ◽  
Arun Rangaswami ◽  
Doruk Ozgediz ◽  
...  
Keyword(s):  
Family History ◽  
Neuroendocrine Tumor ◽  
Vasoactive Intestinal Peptide ◽  
Neuroendocrine Tumors ◽  
Chronic Diarrhea ◽  
Uterine Cancer ◽  
Secretory Diarrhea ◽  
Watery Diarrhea ◽  
History Of ◽  
Well Differentiated

Abstract Background: VIPoma, also known as Watery Diarrhea-Hypokalemia- achlorhydria (WDHA) Syndrome is a rare manifestation of multiple endocrine neoplasia syndrome type 1 (MEN1). Vasoactive intestinal peptide, part of the secretin-glucagon family, may be overexcreted in tumors associated with MEN1 and results in diarrhea that persists while fasting, resulting in massive secretion of water and electrolytes. First-line treatment is surgical resection. Clinical Case: We present a 13-year-old male with a past medical history of chronic diarrhea for four years who was transferred from an outside hospital for severe diarrhea and associated electrolyte derangements, including hypokalemia of <1.0 mmol/L (3.5-5.0 mmol/L), sodium of 120 (135-145 mmol/L), and chloride of 84 mmol/L (101-110 mmol/L). Family history was significant for pancreatic, breast, thyroid, stomach, parathyroid, and uterine cancer, as well as hyperparathyroidism and nephrolithiasis. The patient had been admitted to the hospital before for a similar episode of acute on chronic diarrhea but was treated for infectious diarrhea during that admission. CT enterography was obtained during this hospitalization and it revealed multiple solid and heterogeneous appearing pancreatic masses in the head and tail of the pancreas. Work-up was significant for pancreatic polypeptide of 1,523 pg/mL (92-752 pg/mL) and vasoactive intestinal peptide of 1,105 pg/mL (<75 pg/mL). Pancreatic biopsy revealed a grade 2 pancreatic neuroendocrine tumor. Genetic testing revealed a known pathogenic mutation in the menin gene p.R526 (c. 1579>T, pArg527). A pylorus-preserving total pancreatectomy, duodenectomy, cholecystectomy, and splenectomy was performed and surgical pathology revealed a well-differentiated grade 1 neuroendocrine tumor in the head of the pancreas and a well-differentiated grade 2 neuroendocrine tumor in the tail of the pancreas. Since the surgery, the patient currently has no signs of other neuroendocrine tumors associated with MEN1 but continues to follow-up for regular screening for other tumors associated with MEN1. Clinical Lessons: 1. VIPoma, also known as Watery Diarrhea- Hypokalemia- Achlorhydria Syndrome, is characterized by secretory diarrhea that persists while fasting. 2. VIPoma should be considered in patients with a history of chronic diarrhea and a significant family history of neuroendocrine tumors.

scholarly journals Role of Endoscopic Ultrasound in Gastroenteropancreatic Neuroendocrine Tumors and Update on Their Treatment

2013 ◽  
Vol 47 (1) ◽  
pp. 54-60
Author(s):  
Vishal Sharma ◽  
Surinder Singh Rana ◽  
Deepak Kumar Bhasin
Keyword(s):  
Neuroendocrine Tumors ◽  
Endoscopic Ultrasound ◽  
Imaging Techniques ◽  
Somatostatin Analogs ◽  
Neuroendocrine Cells ◽  
Molecular Therapy ◽  
Long Term Results ◽  
Gi Tract ◽  
Gastroenteropancreatic Neuroendocrine Tumors

ABSTRACT The gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare tumors and include all tumors arising from the gastrointestinal (GI) or pancreatic neuroendocrine cells. They can occur anywhere in the GI tract with the small intestine, pancreas and rectum being the common GI sites. Because of nonspecific symptoms they are difficult to diagnose and diagnosis is often delayed by years. Advancement in cross-sectional imaging techniques and advent of radionuclide-labeled somatostatin analogs have improved our accuracy of diagnosis and staging GEP NETs. Endoscopic ultrasound (EUS) with its unique combination of endoscopy and ultrasound provides high resolution images of GI tract wall as well as the surrounding solid parenchymal organs and therefore is an important investigation for the diagnosis and staging of GEP NETs. Surgery is the treatment of choice with good long-term results in patients with localized GEP-NETs. Control of symptoms in functional NETs is warranted to improve the quality of life of the patient. Somatostatin and its analogs like octreotide and lanreotide have been used to control symptoms because of functional NETs. The management of metastatic GEP NETs includes control of symptoms and therapy to decrease/stop tumor growth that includes somatostatin and its analogs and chemotherapy. Newer therapeutic modalities like peptide receptor radionuclide therapy (PRRT) and molecular therapy hold considerable promise. How to cite this article Rana SS, Sharma V, Bhasin DK. Role of Endoscopic Ultrasound in Gastroenteropancreatic Neuroendocrine Tumors and Update on Their Treatment. J Postgrad Med Edu Res 2013;47(1):54-60.

scholarly journals Calcified Liver Metastases from a Neuroendocrine Tumor of the Lung (Atypical Carcinoid) – A Case Report

2017 ◽  
Vol 03 (02) ◽  
pp. E89-E90
Author(s):  
Rolf Reiter ◽  
Jochen Maul ◽  
Jan Preis ◽  
Hendrik Blaeker ◽  
Zarko Grozdanovic
Keyword(s):  
Case Report ◽  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Incidence Rate ◽  
Surgical Resection ◽  
Neuroendocrine Tumors ◽  
Medical Management ◽  
Atypical Carcinoid ◽  
Rare Tumors ◽  
Peripheral Location

Pulmonary neuroendocrine tumors (NETs) are rare tumors with an incidence rate of 0.2–2/100 000 population/year in Western countries (M. E. Caplin et al. Ann Oncol 2015; 26:1604–20). They account for 1–2% of all neoplasms of the lung and constitute one-fourth to one-third of all NETs. Atypical carcinoids are far less common than typical carcinoids and predominantly occur in male smokers aged 50 –70 years. Most pulmonary NETs are asymptomatic due to their peripheral location. Surgical resection is the treatment of choice. Medical management should take hormone-related symptoms into account.

Sign in / Sign up

Export Citation Format

Share Document