Introduction. Gastroenteropancreatic neuroendocrine tumors comprise a
heterogeneous group of neoplasms that originate from the cells of the diffuse
endocrine system within the gastrointestinal tract and pancreas. The
diagnostic procedures and therapy of patients with gastroenteropancreatic
neuroendocrine tumors is complex and requires a multidisciplinary approach.
Case Report. A 51-year-old patient visited a Gastroenterology Outpatient
Clinic for examination complaining of redness, facial swelling and frequent
watery diarrhea since the age of 48 years. The clinical examination revealed
subicterus, systolic murmur, and hepatomegaly. The patient received an
extensive examination that included specific laboratory tests and various
imaging techniques (endoscopy, radiology, cardiology, nuclear imaging) at the
regional medical center. He was referred to a tertiary medical center,
including the national Center for the Treatment of Neuroendocrine Tumors, and
a metastatic neuroendocrine tumor, most likely affecting the ileum, was
established. After preoperative cardiac and anesthesiological assessments, an
elective surgical procedure was performed, with a
pathohistological/immunohistochemical confirmation of a grade 1
neuroendocrine tumor of the ileum. Conclusion. The process of diagnosing
gastroenteropancreatic neuroendocrine tumors, after the onset of symptoms, is
often long, associated with comorbidities, and requires a multidisciplinary
approach to diagnosis, treatment and monitoring.