scholarly journals Iga nephropathy

2004 ◽  
Vol 132 (1-2) ◽  
pp. 41-43
Author(s):  
Gordana Basta-Jovanovic
Keyword(s):  
Electron Microscopy ◽  
Nephrotic Syndrome ◽  
Light Microscopy ◽  
Iga Nephropathy ◽  
Immune Complex ◽  
Clinical Manifestations ◽  
Glomerular Disease ◽  
Glomerular Mesangium ◽  
Immune Deposits

IgA nephropathy is glomerular disease first described in 1968 by Berger, named after him Morbus Berger. The disease is characterized by the presence of IgA dominant or codominant imunoglobuline deposits in glomerular mesangium which can be demostrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or microskopic, isolated or combined with proteinuria which can be of nephrotic range. In some cases nephrotic syndrome can be the first clinical presentatio. In 10% renal insuficiency can be present at the onset of the disease. By light microscopy IgA can manifest any of the histologie phenotypes of immune complex mediated prolifferative glomerulonephritis. According to light microscopy findings a classification systeme have been used to categorize the histologie patterns of IgA nephropathy. Glomerular changes in IgA nephropathy are prolifferative and can be focal or diffuse accompanied by crescentic formation in many cases. Immune deposits seen by electron microscopy appear as electron dense deposites most numerous in mesangium.

scholarly journals Immune Complex-positive Glomerulonephritis in Antineutrophil Cytoplasmic Antibody-positive Patients

2017 ◽  
Vol 51 (4) ◽  
pp. 166-169
Author(s):  
Kusum Joshi ◽  
Parikshaa Gupta ◽  
Seema Chhabra ◽  
Priyanka Bhagat ◽  
Shreekant Bharti ◽  
...  
Keyword(s):  
Light Microscopy ◽  
Immune Complex ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Immunoglobulin M ◽  
Direct Immunofluorescence ◽  
Immune Deposits ◽  
Renal Biopsies

ABSTRACT Antineutrophil cytoplasmic antibody (ANCA)-positive glomerulonephritis (GN) has traditionally been considered pauci-immune (PI); however, various reports have demonstrated the presence of immune reactants in a subset of these cases. The study was done to evaluate the prevalence of immune deposits in ANCApositive GN by direct immunofluorescence (DIF). Renal biopsies of 35 patients with ANCA-positive GN were retrospectively analyzed for light microscopic and DIF findings to look for the presence of immune reactants and to correlate these with the corresponding histologic features. Twenty-seven cases (77.2%) showed PI-GN while 8 (22.8%) cases showed. 2+ positivity for one or more immune reactants in the mesangium and/or capillary loops and were categorized as ANCA-positive immune complex GN. Of these, seven were positive for perinuclear (P-ANCA) and one for cytoplasmic (C-ANCA). Immunoglobulin M (IgM) was the most frequent immunoglobulin. On light microscopy, these cases exhibited significantly increased mesangial cellularity (p = 0.033) and more number of normal glomeruli as compared with PI cases (p = 0.015). How to cite this article Bhagat P, Bharti S, Gupta P, Minz RW, Joshi K, Chhabra S. Immune Complex-positive Glomerulonephritis in Antineutrophil Cytoplasmic Antibody-positive Patients. J Postgrad Med Edu Res 2017;51(4):166-169.

scholarly journals Spectrum of Biopsy Proven Glomerular Disease in Children at Kanti Children’s Hospital

2015 ◽  
Vol 34 (3) ◽  
pp. 225-229 ◽  
Author(s):  
N Khatun ◽  
KP Bista ◽  
C Mahaseth
Keyword(s):  
Nephrotic Syndrome ◽  
Lupus Nephritis ◽  
Renal Disease ◽  
Iga Nephropathy ◽  
Kidney Biopsy ◽  
Demographic Data ◽  
Glomerular Disease ◽  
Children's Hospital ◽  
Steroid Dependent ◽  
Children’S Hospital

Introduction: Glomerular disease is one of the most common forms of renal disease and can have many different clinical presentations. However there is variation in the prevalence in the type of glomerular disease according to geographical location and race of population. The aim of the study was to find the overall distribution pattern of glomerular disease based on renal biopsies. Material and Methods: The medical records of all children who underwent kidney biopsy (n=29) between January 2012-june 2014 were analyzed. In this retrospective study we review children from Kanti Children’s Hospital, Nephrology Department. Demographic data including age, sex and indication of kidney biopsy as well as complication of the procedures were recorded. Result: A total number of thirty one biopsies were done. Two children were excluded from the study due to inadequate tissue and artifacts defects in preservative. The remaining twenty nine biopsies were included in the study and analyzed. Renal disease was found nearly equal in both male and female (51.72% vs. 48.27%).Mean age was 10.95±3.30 years. Maximum number of biopsies (75.86%) was performed between 10- 15 years. The most common indication of the kidney biopsy was nephrotic syndrome (steroid resistant nephrotic syndrome and steroid dependent nephrotic syndrome, 31.02% followed by lupus nephritis 27.58%.The most common glomerular disease were focal segmental glomerulosclerosis and lupus nephritis both contribute 27.58%. Among lupus nephritis class III was found more common (44.44%) in children. IgA nephropathy was also contribute (17.24%) in all glomerular disease. Regarding the kidney biopsy complication gross hematuria was observed in 6.89% of children which was self-limited. Conclusion: FSGS and lupus nephritis is becoming the most common glomerular disease in children attending the Kanti Children Hospital. IgA nephropathy was also contribute the glomerular disease in the children. J Nepal Paediatr Soc 2014;34(3):225-229   DOI: http://dx.doi.org/10.3126/jnps.v34i3.11162  

scholarly journals A Pattern of Glomerular Diseases in Egyptian Children: A Single-center Experience

2021 ◽  
Vol 9 (B) ◽  
pp. 1305-1312
Author(s):  
Hoda Atef Abdelsattar Ibrahim ◽  
Aya Amin ◽  
Ahmed Zeid ◽  
Samar Sabry ◽  
Hesham Safouh
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Glomerular Disease ◽  
Diffuse Mesangial Sclerosis ◽  
Gross Hematuria ◽  
Glomerular Diseases ◽  
Nephritic Syndrome ◽  
Study Results ◽  
Egyptian Children ◽  
Membranous Gn

BACKGROUND: Findings indicative of the glomerular disease are proteinuria, hematuria, nephrotic syndrome (NS), hypertension, and renal insufficiency. These presentations can be used to define different clinical patterns that resemble different underlying etiologies. METHODS: This study is a cross-sectional study enrolled in Children Hospital Cairo University. The study participants were recruited on two stages, retrospective and prospective stages. In the retrospective stage, all eligible patients across 5 years (between 2011 and 2015) with any glomerular disease were included in the study. In addition, prospectively, the new cases a long 6 months (from February 2016 till July 2016) with glomerular diseases were included in the study. RESULTS: A total of 594 cases with different glomerular diseases were identified. Cases were two groups: The retrospective group that involved 543 cases and the prospective group that included 51 cases. In the retrospective part of the study, the most common presentations were NS (68%), nephritis (16.4%), gross hematuria (10.5%), and nephrotic/nephritic syndrome (3.5%). The most common biopsies in the retrospective study were NS: MCNS (27.3%), NS: focal segmental glomerulosclerosis (FSGS) (23.4%), NS: Mesangioproliferative GN (9.4%), NS: Membranous GN (2.3%), Crescentric GN (3.9%), Membranous GN (0.8%), MPGN (0.8%), congenital nephrotic syndrome (CNS):Diffuse Mesangial Sclerosis (3.9%), CNS: Finnish type (2.3%), Alport (4.7%), IgA nephropathy (3.9%), IgM nephropathy (1.6%), lupus nephritis (LN) (3.1%), Thin basement membrane disease (3.1%), and others (9.4%) In the prospective study, the most common presentations were NS (76.5%), nephritis (11.8%), nephrotic/nephritic syndrome (7.8%), and gross hematuria (3.9%). The biopsies results were mainly NS: FSGS (33.3%) and NS: MCNS (33.3%). Other biopsies results in the prospective part were NS: Mesangioproliferative GN (16.7%), LN (8.3%), and IgA nephropathy (8.3%). CONCLUSION: The most common glomerular disease in childhood is NS. The most common pathology of glomerular diseases is minimal change NS.

Immunoglobulin A-dominant post-infectious glomerulonephritis

2018 ◽  
Author(s):  
Bernardo Rodriguez-Iturbe ◽  
Mark Haas
Keyword(s):  
Electron Microscopy ◽  
Staphylococcus Aureus ◽  
Nephrotic Syndrome ◽  
Risk Factor ◽  
Iga Nephropathy ◽  
Immunoglobulin A ◽  
Renal Lesion ◽  
Crescent Formation ◽  
Histological Features ◽  
Post Infectious

Immunoglobulin A (IgA)-dominant post-infectious glomerulonephritis is usually associated with infections with Staphylococcus aureus. It is most commonly seen in patients over 60, and particularly in men. The renal lesion is acute and severe, and commonly includes crescent formation, although the described histological features vary widely. IgA is the dominant immunoglobulin and in later phases when capillary deposits are resolving it may be impossible to distinguish the condition from IgA nephropathy without the use of electron microscopy. Diabetes appears to be a risk factor. Complement levels are frequently low but may be normal. Clinically there is often severe nephrotic syndrome and hypertension may be less prominent.

Sensorineural deafness associated with IgA nephropathy

1989 ◽  
Vol 103 (4) ◽  
pp. 412-412 ◽  
Author(s):  
N. L. Ataya
Keyword(s):  
Renal Biopsy ◽  
Iga Nephropathy ◽  
Immune Complex ◽  
Sensorineural Deafness ◽  
Immune Complex Glomerulonephritis ◽  
Glomerular Mesangium ◽  
Subsequent Onset

AbstractIgA nephropathy is an immune complex glomerulonephritis in which examination of the renal biopsy by immu-nofluorescence reveals IgA as the predominant antibody deposited in the glomerular mesangium (Clarkson et al., 1984). It was first described by Berger in 1969. The disease is more common in males and occurs generally during the second or third decades of life (Emancipator et al., 1985). A case of established IgA nephropathy with subsequent onset of sensorineural deafness is described.

Minimal-change nephropathy and focal segmental glomerulosclerosis

2010 ◽  
pp. 3978-3985
Author(s):  
Dwomoa Adu
Keyword(s):  
Electron Microscopy ◽  
Nephrotic Syndrome ◽  
Epithelial Cell ◽  
Basement Membrane ◽  
Light Microscopy ◽  
Outer Surface ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Immune Mediated ◽  
Inflammatory Drugs

Minimal-change nephrotic syndrome (MCNS) is an immune-mediated condition, usually of unknown cause, but which can sometimes be associated with Hodgkin’s disease or the use of nonsteroidal anti-inflammatory drugs. On light microscopy the glomeruli appear normal or small, and on electron microscopy there is effacement of epithelial-cell foot processes over the outer surface of the glomerular basement membrane. MCNS is the cause of about 80% of cases of nephrotic syndrome in children and 20% in adults....

Minimal change disease

2019 ◽  
pp. 175-224
Author(s):  
Claudio Ponticelli ◽  
Richard J Glassock ◽  
Rosanna Coppo
Keyword(s):  
Electron Microscopy ◽  
Nephrotic Syndrome ◽  
Light Microscopy ◽  
Renal Biopsy ◽  
Minimal Change Disease ◽  
The Elderly ◽  
Minimal Change ◽  
Common Cause ◽  
Foot Process

This chapter discusses minimal change disease (MCD), which is chiefly characterized clinically by episodes of nephrotic syndrome (NS) and presents with massive proteinuria, hypo-albuminaemia, hyperlipidaemia, and generalized oedema, Morphologically, it is characterized by no or only minimal glomerular abnormalities in a renal biopsy examined by light microscopy and immunofluorescence, while there is diffuse effacement of the podocyte foot process by electron microscopy. MCD is the most common cause of NS in children but it may also develop at any age, including in the elderly. This chapter covers the pathology, presentation, and treatment of MCD, including practical tips for the practitioner.

scholarly journals Iga nephropathy: clinical-morphologic correlation

2003 ◽  
Vol 131 (7-8) ◽  
pp. 290-293
Author(s):  
Gordana Basta-Jovanovic ◽  
Radovan Bogdanovic ◽  
Sanja Radojevic ◽  
Vidosava Nesic
Keyword(s):  
Iga Nephropathy ◽  
Clinical Manifestations ◽  
Glomerular Disease ◽  
Morphologic Correlation ◽  
Morphologic Changes

IgA nephropathy is glomerular disease caracterized by the presence morphologic changes as wella as the prognosis is in correlation with of IgA dominant or codominant imunoglobuline deposits in glomer-the amount of proteinuria. The prognosis is better in children. ular mesangium which can be demostrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or mikroskopic, isolated or combined with proteinuria, which can be of nephrotic range. The prognosis o the disease is better if presented with haematuria. Intensity of????.

Two- or three-way observations of the identical cell elements within the same sections by LM, TEM and/or SEM

1978 ◽  
Vol 36 (2) ◽  
pp. 82-83 ◽  
Author(s):  
Nakazo Watari ◽  
Yasuaki Hotta ◽  
Yoshio Mabuchi
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Fine Structure ◽  
Light Microscopy ◽  
Thin Sections ◽  
Transmission Electron ◽  
Identical Cell ◽  
Electron Microscopes ◽  
Scanning Electron

It is very useful if we can observe the identical cell elements within the same sections by light microscopy (LM), transmission electron microscopy (TEM) and/or scanning electron microscopy (SEM) sequentially, because, the cell fine structure can not be indicated by LM, while the color is; on the other hand, the cell fine structure can be very easily observed by EM, although its color properties may not. However, there is one problem in that LM requires thick sections of over 1 μm, while EM needs very thin sections of under 100 nm. Recently, we have developed a new method to observe the same cell elements within the same plastic sections using both light and transmission (conventional or high-voltage) electron microscopes.In this paper, we have developed two new observation methods for the identical cell elements within the same sections, both plastic-embedded and paraffin-embedded, using light microscopy, transmission electron microscopy and/or scanning electron microscopy (Fig. 1).

Tumor Diagnosis

1982 ◽  
Vol 40 ◽  
pp. 262-265
Author(s):  
Bruce Mackay
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Differential Diagnosis ◽  
Light Microscopy ◽  
Clinical Examination ◽  
Ultrastructural Study ◽  
Diagnostic Procedures ◽  
Specific Diagnosis ◽  
Transmission Electron ◽  
Microscopic Diagnosis

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.

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