Chapter Two of Hume’s Scepticism charts the development of Academic scepticism from Cicero and Augustine, through the Middle Ages and the Renaissance, and into early modernity. The exposition is organized around sceptical ideas that anticipated or may have influenced David Hume, who describes himself an ‘academical’ sceptic. The chapter also sets out Cicero’s influence upon Hume, scepticism at the college in La Flèche where Hume wrote much of A Treatise of Human Nature, and Hume’s self-conception of Academic scepticism. Accounts of sceptical ideas in Marin Mersenne, Simon Foucher, John Locke, Pierre-Daniel Huet, and Pierre Bayle set the stage for Hume’s own Academicism. The chapter closes with a five-point General Framework defining Academic Scepticism.