AbstractThis article reports a case in which a patient, an adult black male, was diagnosed as having sialadenosis of an idiopathic type, since clinical, computed tomography and laboratory examinations did not disclose any other abnormalities that could be associated with the glandular swelling. As this condition is quite harmless, requiring no intervention, unless for aesthetic reason, the patient was dismissed, being monitored sporadically. But after 8 months since the first consultation, the patient was diagnosed as having an advanced esophageal squamous cell carcinoma, and eventually died of this disease. This report, therefore, raises the question whether there was any relation with the sialadenosis and the esophageal carcinoma. This question is very speculative, but it stands as a notice for clinicians in future cases of idiopathic sialadenosis to evaluate the patient for an underlying malignant disease.