scholarly journals Clinical Efficacy of 25% Potassium Oxalate Solution of Dentin Hypersensitivity after Periodontal Therapy.

1993 ◽  
Vol 35 (1) ◽  
pp. 162-171
Author(s):  
Hiroshi ITO ◽  
Takashi YOSHIHAMA ◽  
Hiroshi NAKAYA ◽  
Kyuichi KAMOI
Keyword(s):  
Clinical Efficacy ◽  
Periodontal Therapy ◽  
Dentin Hypersensitivity ◽  
Potassium Oxalate ◽  
Oxalate Solution

scholarly journals Clinical Efficacy of Repeated Applications of Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1178
Author(s):  
Oi Leng Tan ◽  
Syarida Hasnur Safii ◽  
Masfueh Razali
Keyword(s):  
Systematic Review ◽  
Drug Delivery ◽  
Clinical Efficacy ◽  
Grey Literature ◽  
Periodontal Therapy ◽  
Local Drug Delivery ◽  
Control Group ◽  
Cochrane Central Register ◽  
Nonsurgical Periodontal Therapy ◽  
Repeated Applications

The aim of this systematic review is to compare the clinical efficacy of repeated applications of local drug delivery and adjunctive agents (LDAs) in nonsurgical periodontal therapy (NSPT) compared to subgingival mechanical debridement (SMD) alone. The Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, EMBASE, Web of Science, hand-searched literature and grey literature databases were searched for randomized controlled clinical trials (RCTs) with a minimum of 6-month follow-up. The outcomes of interest were changes in probing pocket depth and clinical attachment level as well as patient-centred outcomes. Of 1094 studies identified, 16 RCTs were included in the qualitative analysis. Across 11 different adjuncts analysed, only two studies utilizing minocycline gel/ointment and antimicrobial photodynamic therapy (aPDT) with indocyanine green photosensitizer had statistically significant differences in primary outcomes when compared to their control groups. Only one study on aPDT methylene blue 0.005% had compared single versus multiple applications against its control group. A mean range of 0.27–3.82 mm PD reduction and −0.09–2.82 mm CAL gain were observed with repeated LDA application. Considerable clinical heterogeneity and methodological flaws in the included studies preclude any definitive conclusions regarding the clinical efficacy of repeated LDA applications. Future RCTs with a direct comparison between single and repeated applications should be conducted to confirm or refute the clinical advantages of repeated LDA application in the nonsurgical management of periodontitis.

Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis

2019 ◽  
Vol 82 ◽  
pp. 11-21 ◽  
Author(s):  
Cristiane de Melo Alencar ◽  
Brennda Lucy Freitas de Paula ◽  
Mariangela Ivette Guanipa Ortiz ◽  
Marcela Baraúna Magno ◽  
Cecy Martins Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Dentin Hypersensitivity

scholarly journals Does a pretreatment with a dentine hypersensitivity mouth-rinse compensate the pain caused by professional mechanical plaque removal? A single-blind randomized controlled clinical trial

2020 ◽  
Author(s):  
Sonja H. M. Derman ◽  
Eva-Maria Lantwin ◽  
Anna Greta Barbe ◽  
Michael J. Noack
Keyword(s):  
Rating Scale ◽  
Periodontal Therapy ◽  
Point Of View ◽  
Controlled Clinical Trial ◽  
Mouth Rinse ◽  
Potassium Oxalate ◽  
Plaque Removal ◽  
Mouth Rinses ◽  
Supportive Periodontal Therapy ◽  
Dentinal Hypersensitivity

Abstract Objectives Pain is affecting acceptance of supportive periodontal therapy and primary periodontitis prevention. Our objective was to evaluate the efficacy of a 1-week pre-treatment use of dentinal-hypersensitivity-reducing mouth-rinses (DHM) in periodontal maintenance (SPT) or dental prophylaxis patients. Material and methods One hundred fifty-five participants attending for professional mechanical plaque removal (PMPR) were randomly assigned to use a mouth-rinse twice daily for 1 week prior to their next PMPR. Rinses were containing either potassium oxalate (n = 52), arginine (n = 52), or herbal extracts (n = 51). At baseline and reassessment, procedural pain was assessed by visual analogue scale (VAS) and verbal rating scale (VRS). Self-reported efficacy was documented. Results No inter-group differences were estimated between both test groups and the control for baseline and reassessment means (VAS, VRS). In the SPT group, VAS reduction and self-reported efficacy were found (p < 0.05). Conclusion The 1-week use of DHM failed to show a predictable effect on discomfort during PMPR overall. Around 20% of the patients showed a quantifiable benefit from both test mouth-rinses, whereas more than 50% reported a subjective pain reduction. Focusing patients undergoing supportive periodontal therapy, quantifiable effects were found for both test groups. From a patient’s point of view, DHM might be a suitable adjunct to enhance procedural comfort, especially in patients with a history of periodontitis. Clinical relevance The 1-week use of the dentinal-hypersensitivity-reducing mouth-rinses prior to professional-mechanical-plaque-removal showed to be a suitable adjunct to enhance procedural comfort during instrumentation, especially in patients undergoing supportive periodontal therapy. Registration number: DRKS00010811

A long-term evaluation of experimental potassium oxalate concentrations on dentin hypersensitivity reduction: A triple-blind randomized clinical trial

2019 ◽  
Vol 89 ◽  
pp. 103180
Author(s):  
Alexia da Mata Galvão ◽  
Livia Fávaro Zeola ◽  
Guilherme Faria Moura ◽  
Daniela Navarro Ribeiro Teixeira ◽  
Ramon Corrêa de Queiroz Gonzaga ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dentin Hypersensitivity ◽  
Potassium Oxalate ◽  
Term Evaluation

scholarly journals Effect of iron gel on dentin permeability

2011 ◽  
Vol 22 (3) ◽  
pp. 198-202 ◽  
Author(s):  
Sílvia Helena de Carvalho Sales-Peres ◽  
João Victor Donazan Reinato ◽  
André de Carvalho Sales-Peres ◽  
Juliane Avansini Marsicano
Keyword(s):  
Hydraulic Conductance ◽  
Smear Layer ◽  
Iron Sulfate ◽  
Dentin Hypersensitivity ◽  
Third Molars ◽  
Potassium Oxalate ◽  
Significance Level ◽  
Dentin Permeability ◽  
Gel Ph

This study evaluated in vitro the effect of an experimental gel containing iron on the reduction of hydraulic conductance of dentin. Thirty-six 1-mm-thick dentin discs obtained from extracted human third molars were divided into 3 groups of 10 specimens each. The groups corresponded to the following experimental materials: 1.23% acidulated phosphate fluoride gel, pH 4.1; 3% potassium oxalate gel, pH 4.1 (Oxa-Gel®); and iron sulfate gel (10 mmol/L FeSO4), pH 4.1. The gels were applied to dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. Data were analyzed statistically by ANOVA and Tukey's test at 5% significance level. There was no significant differences (p<0.05) among the groups in any of the conditions for hydraulic conductance reduction, except for smear layer presence. The active agents reduced dentin permeability, but they produced significantly lower (p<0.05) reduction in hydraulic conductance when compared to presence of smear layer. The effectiveness in reducing dentin permeability was not significantly different (p>0.05) among the gels. This study suggests that the iron gel promoted reduction in dentin permeability comparable to that of the other agents and thus may be considered a good clinical alternative for the treatment of dentin hypersensitivity.

scholarly journals Comparative In Vitro Effect of TiF4 to NaF and Potassium Oxalate on Reduction of Dentin Hydraulic Conductance

2014 ◽  
Vol 39 (4) ◽  
pp. 427-432 ◽  
Author(s):  
M Calabria ◽  
R Porfirio ◽  
S Fernandes ◽  
L Wang ◽  
M Buzalaf ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Hydraulic Conductance ◽  
Smear Layer ◽  
Acid Etching ◽  
Dentin Hypersensitivity ◽  
Potassium Oxalate ◽  
Titanium Tetrafluoride ◽  
Dentin Permeability ◽  
Vitro Effect

SUMMARY Dentin hypersensitivity (DH) is related to an increase in dentin permeability. This study tested the effect of titanium tetrafluoride (TiF4) compared with sodium fluoride (NaF) and potassium oxalate gel on reducing hydraulic conductance (Lp) from the perspective of diminishing dentin permeability. The Lp of the dentin disks (1.0 ± 0.2 mm) was evaluated using Flodec. The maximum Lp values of each disk were taken after phosphoric acid etching (15 seconds) and randomly allocated to seven groups (n=8) according to the treatments. The minimum (smear layer) and the maximum (after acid etching) Lp values were recorded. Treatments were performed for 4 minutes as follows: 1) NaF varnish 2) and solution (2.45% F, pH 5.0), 3) TiF4 varnish and 4) solution (2.45% F, pH 1.0), 5) 3% potassium oxalate gel, 6) free fluoride varnish (placebo, pH 5.0), 7) and no treatment (control). The Lp after each treatment was assessed. Samples were exposed to an erosive challenge (6% citric acid, pH 2.1, 1 minute), and the final Lp was recorded. The data were statistically analyzed using repeated measures two-way analysis of variance (p&lt;0.05). All treatments were effective in reducing dentin Lp compared with the control immediately after the application. However, only potassium oxalate and NaF varnish significantly differed from placebo varnish (p&lt;0.0001). The same results were found after the erosive challenge. Therefore, the TiF4 was less effective than the NaF varnish and potassium oxalate gel in reducing dentin permeability. Using this experimental model, both NaF varnish and potassium oxalate gel reduced the Lp similarly to the presence of smear layer.

scholarly journals Effects of non-surgical periodontal therapy on periodontal clinical data in periodontitis patients with rheumatoid arthritis: a meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yu Huang ◽  
Zheng Zhang ◽  
Youli Zheng ◽  
Zhulan Zhao ◽  
Yang Zhong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Publication Bias ◽  
Clinical Efficacy ◽  
Clinical Data ◽  
Random Effect ◽  
Random Effect Model ◽  
Periodontal Therapy ◽  
Sensitivity Analyses ◽  
Controlled Trials ◽  
Cochrane Central Register

Abstract Backgrounds To date, there is still no consensus about the clinical efficacy of non-surgical periodontal therapy in rheumatoid arthritis (RA) patients with periodontitis. Therefore, the aim of this study was to summarize clinical data regarding the efficacy of scaling and root planing (SRP) in patients with RA and periodontitis compared to non-RA periodontitis patients. Methods We selected randomized controlled trials (RCTs) that compared periodontal clinical data in RA as compared to non-RA periodontitis patients by searching Embase, PubMed and Cochrane Central Register of Controlled Trials and by manually retrieving from the earliest records to March 8, 2021. The overall effect size of plaque index (PI), gingival index (GI), attachment loss (AL), probing depth (PD) and bleeding on probing (BOP) were calculated by either a fixed or random-effect model, and subgroup analyses were conducted according to the different time points of follow-up. Two investigators extracted the data and assess the accuracy of the obtained results with 95% of Confidence Intervals (CI). Cochrane Collaboration's tool was responsible for the evaluation of the literature quality and the inter-study heterogeneity was evaluated by Q test and I2 statistic. Sensitivity analyses were applied for results with heterogeneity. Publication bias was determined by Begg's test, Egger's test and the trim-and-fill method. Results Seven RCTs including 212 patients eventually met the inclusion criteria for the study. As the primary results, the change of PD was not statistically significant and in the secondary results changes of PI, GI, AL and BOP were also not statistically significant in RA patients with periodontitis compared to non-RA periodontitis patients. In subgroup analysis, a larger BOP reduction at 3 months, PI and AL reduction at 6 months were observed in patients with RA and periodontitis group. The results of sensitivity analyses had no significant effect. No evidence of potential publication bias was tested. There were some limitations due to the small number of eligible RCTs. Conclusions SRP is equally effective in RA as compared to non-RA periodontitis patients. It suggests RA does not affect the clinical efficacy of non-surgical periodontal therapy. These results could serve evidence-based practice.

scholarly journals Effects of Non-surgical Periodontal Therapy on Periodontal Clinical Data in Periodontitis Patients With Rheumatoid Arthritis: a Meta-analysis

2021 ◽  
Author(s):  
Yu Huang ◽  
Zheng Zhang ◽  
Youli Zheng ◽  
Zhulan Zhao ◽  
Yang Zhong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Publication Bias ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Periodontal Therapy ◽  
Sensitivity Analyses ◽  
Cochrane Central Register ◽  
Randomized Controlled Clinical Trials

Abstract Backgrounds: To date, there is still no consensus about the clinical efficacy of non-surgical periodontal therapy in rheumatoid arthritis (RA) patients with periodontitis. Therefore, the overall aim of this study was to summarize available data regarding the clinical efficacy of scaling and root planing (SRP) in patients with RA and periodontitis compared to patients with periodontitis alone.Methods: A meta-analysis of existing randomized controlled clinical trials (RCTs) was conducted. The eligible RCTs were selected through Embase, PubMed and Cochrane Central Register of Controlled Trials and manual retrieval from the earliest records to March 15, 2020 to extract data. The overall effect size of plaque index (PI), gingival index (GI), attachment loss (AL), probing depth (PD) and bleeding on probing (BOP) were calculated by either a fixed or random-effect model, and subgroup analyses were conducted according to the different time points of follow-up. Cochrane Collaboration's tool was responsible for the evaluation of the literature quality and the inter-study heterogeneity was evaluated by Q test and I2 statistic. The authors applied sensitivity analysis for results with heterogeneity. Publication bias was determined by Begg's test, Egger's test and the trim-and-fill method.Results: Eight RCTs eventually met the inclusion criteria for the study. The overall outcomes concerned PI, GI, PD, Al and BOP were 0.42(95% CI 0.02, 0.81), 0.03(95% CI -0.03, 0.10),-0.06mm (95% CI -0.18, 0.06), 0.16mm (95% CI-0.03, 0.36) and 4.15(95% CI -0.26, 8.55), respectively. In subgroup analysis, a larger BOP reduction at 3 months, PI and AL reduction at 6 months were observed in patients with RA and periodontitis group. The results of sensitivity analyses had no significant effect. No evidence of potential publication bias was tested.Conclusions: The authors conclude that SRP is equally effective in patients with periodontitis and RA than in periodontitis ones. This result suggests RA does not affect the clinical efficacy of non-surgical periodontal therapy.

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