scholarly journals A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes

Diabetes ◽  
2006 ◽  
Vol 55 (12) ◽  
pp. 3358-3365 ◽  
Author(s):  
G. Placha ◽  
G. D. Poznik ◽  
J. Dunn ◽  
A. Smiles ◽  
B. Krolewski ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Extended Families ◽  
Genome Wide ◽  
A Genome

Evaluation of serum cystatin C as an indicator of early renal function decline in type 2 diabetes

2014 ◽  
Vol 27 (1) ◽  
pp. 60 ◽  
Author(s):  
AmeerS. Seleem ◽  
NabilA. El-Kafrawy ◽  
AhmedA. Shohaib ◽  
SamarM. Kamal El-Deen ◽  
HaniEl Barbary
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Renal Function Decline

scholarly journals Serum cystatin C is associated with subclinical atherosclerosis in patients with type 2 diabetes: A retrospective study

2017 ◽  
Vol 15 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Yu Kyung Chung ◽  
Young Ju Lee ◽  
Kye Whon Kim ◽  
Ryu Kyoung Cho ◽  
Seung Min Chung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Retrospective Study ◽  
Cystatin C ◽  
Subclinical Atherosclerosis ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients

2017 ◽  
Vol 3 (10) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cystatin C ◽  
Significant Positive Correlation ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Albumin Excretion

Objective This study aimed to find the effect of serum Cystatin C in early diabetic nephropathy.Method This study was conducted in Al Kindy Teaching Hospital during the period from December, 2015 to June, 2016. The study included 90 subjects (30 males and 30 females) with diabetic type 2 and 30 healthy control. Age is between 30 and 70 years. Patients were with no history of liver disease, thyroid or other endocrine diseases through clinical interviewing. They were divided in to three groups. 30 healthy controls, 30 patients with type 2 diabetes mellitus with no albuminuria (albumin excretion in urine <30 μg/ml ) and 30 patients with type 2 diabetes mellitus with micro albuminuria (albumin excretion in urine >30 μg/ml ).Results There were no significant differences in age, body mass index (BMI) among the studied groups (p > 0.05). Serum Cystatin C levels showed significant difference (p < 0.001) among studied groups, it was significantly higher in micro albuminuria than the other two groups. There was highly significant positive correlation between Cystatin C and serum creatinine (r = 0.697, p < 0.001), and a significant negative correlation between Cystatin C and GFR (r = − 0.455, p = 0.011) and show significant positive correlation between Cystatin C and urine albumin (r = 0.526, p = 0.003 ) in type 2 diabetic patients with micro albuminuria.Conclusion Cystatin C is negatively correlated with the amount of GFR, so that Cystatin C considered reliable and sensitive marker for identifyingchanges in GFR. In type 2 diabetes mellitus with micro albuminuria serum Cystatin C level considered predict marker for renal failure.

scholarly journals Assessment of Cystatin C and Microalbumin as Biomarkers for Nephropathy in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 10 (25) ◽  
pp. 1866-1870
Author(s):  
Bhuneshwar Yadav ◽  
Shashidhar K.N ◽  
Raveesha A ◽  
Muninarayana C.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Elevated Serum ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin

BACKGROUND Increased levels of urinary biomarkers can be detected in type 2 diabetic patients before the onset of significant albuminuria and may be used as an early marker of renal injury in diabetic nephropathy (DN) which would play a significant role for the effective management and treatment approaches in diabetic care. We wanted to evaluate cystatin C and microalbumin as effective early biomarkers in assessing nephropathy in patients with type 2 diabetes mellitus in this study. METHODS A cross-sectional study was conducted among 180 subjects grouped into healthy controls, clinically proven T2DM without nephropathy and type 2 DM with nephropathy comprising 60 participants in each group. Fasting and postprandial blood samples and urine samples were collected and analysed by standard methods. eGFR was calculated using CKD-EPI 2012 equation. IBM - SPSS version 20 was used for statistical analysis. RESULTS Diabetic nephropathy patients had significantly elevated serum cystatin C and microalbumin (2.43 ± 0.59, 700.5 ± 591.8 mg / L, respectively), compared to T2DM (0.98 ± 0.26, 63.7 ± 102.9 mg / L, respectively), and the control study subjects (0.81 ± 0.16, 11.15 ± 8.9 mg / L, respectively). Serum cystatin C showed AUC of 0.994 (95 % CI, 0.986 - 1.00) whereas microalbumin showed 0.944 (95 % CI, 0.907 - 0.981). Serum cystatin C showed a sensitivity of 96.7 % and a specificity of 91.7 % at a cutoff point of 1.34 mg / L whereas at a cut-off point of 138.5 mg / L for microalbumin, the sensitivity and specificity were 90 % and 83.3 % respectively. CONCLUSIONS Serum cystatin C and microalbumin both could be considered as markers for early detection of nephropathy in T2DM patients. The more prominent rise in serum cystatin C values provide an earlier diagnosis of diabetic nephropathy among T2DM patients. KEY WORDS Biomarker, Type 2 Diabetes Mellitus, Cystatin C, Diabetic Nephropathy, Microalbumin

Serum cystatin C as an indicator for early detection of diabetic nephropathy in type 2 diabetes mellitus

2019 ◽  
Vol 13 (1) ◽  
pp. 374-381 ◽  
Author(s):  
Mohamed Shawky Elsayed ◽  
Ayman El Badawy ◽  
Abdelmon'em Ahmed ◽  
Rasha Omar ◽  
Amr Mohamed
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Early Detection ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

Usefulness of serum cystatin C in Japanese patients with type 2 diabetes mellitus and nephropathy

2009 ◽  
Vol 83 (2) ◽  
pp. e58-e61 ◽  
Author(s):  
Tetsuya Kimura ◽  
Hiroki Ikeda ◽  
Jun Fujikawa ◽  
Kazuhiro Nomura ◽  
Tomohisa Aoyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cystatin C ◽  
Japanese Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin
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