Evaluation of Hepatic Steatosis and Fibrosis Using Transient Elastography in Partial Lipodystrophy Patients

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 259-LB
Author(s):  
FÁBIO F. DOS SANTOS ◽  
LUIZ FELLIPE C. VIOLA ◽  
FELIPE O. MATSUURA ◽  
CYNTHIA M. VALERIO ◽  
AMELIO F. GODOY-MATOS ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Partial Lipodystrophy

scholarly journals Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3070
Author(s):  
Valentina Cossiga ◽  
Vincenzo Lembo ◽  
Maria Guarino ◽  
Concetta Tuccillo ◽  
Federica Morando ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Receptor ◽  
Hepatic Steatosis ◽  
Plant Extracts ◽  
Elaeis Guineensis ◽  
Transient Elastography ◽  
Coffea Canephora ◽  
Receptor Expression ◽  
Model Assessment ◽  
Alcoholic Fatty Liver

Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and diabetes. A reduction in insulin receptor (IR) expression has been reported in these patients. The aims of this study were to evaluate the effects of a mixture of plant extracts consisting of Berberis aristata, Elaeis guineensis and decaffeinated green coffee by Coffea canephora on the improvement of glycaemic profile, through the modulation of IR levels, and of hepatic steatosis in NAFLD patients. Forty-nine patients with a grade of steatosis S1-S2 were randomly allocated to the treatment with plant extracts or placebo for six months. Hepatic steatosis was evaluated using transient elastography with CAP (controlled attenuation parameter). Glucose, insulin, and IR levels were measured in serum samples. At the end of the study, patients treated with plant extracts displayed a significant reduction of serum glucose (p < 0.001), insulin levels (p < 0.01), homeostatic model assessment for insulin resistance (HOMA-IR) index (p < 0.001), and CAP value (p < 0.01) compared to placebo. Moreover, the IR expression was increased significantly in the plant extracts group compared to the placebo group (p < 0.05). The combination of plant extracts increases serum IR levels, determining amelioration of glycemic profile and improvement of hepatic steatosis in NAFLD patients.

Hepatic Steatosis in Dunnigan-Type Familial Partial Lipodystrophy

2005 ◽  
Vol 100 (10) ◽  
pp. 2218-2224 ◽  
Author(s):  
Angelika Ludtke ◽  
Janine Genschel ◽  
Georg Brabant ◽  
Jurgen Bauditz ◽  
Matthias Taupitz ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Partial Lipodystrophy ◽  
Familial Partial Lipodystrophy

Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography

2012 ◽  
Vol 32 (6) ◽  
pp. 902-910 ◽  
Author(s):  
Robert P. Myers ◽  
Aaron Pollett ◽  
Richard Kirsch ◽  
Gilles Pomier-Layrargues ◽  
Melanie Beaton ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Noninvasive Method ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values

2018 ◽  
Vol 56 (01) ◽  
pp. 36-42 ◽  
Author(s):  
Johanna Galaski ◽  
Lisa Schulz ◽  
Jenny Krause ◽  
Ansgar Lohse
Keyword(s):  
Liver Biopsy ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Histological Grade ◽  
Histological Evaluation ◽  
Clinical Parameters ◽  
Diagnostic Validity ◽  
Ultrasound Guided ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

Abstract Objective The controlled attenuation parameter (CAP) measured by transient elastography allows for the noninvasive assessment of hepatic steatosis. However, discrepant results between CAP values and histological evaluation have been reported in particular with high CAP values. We therefore investigated the diagnostic validity of high CAP measurements. Methods Forty patients with liver disease and CAP measurements > 300 dB/m that underwent ultrasound-guided or minilaparoscopic liver biopsy were retrospectively enrolled. CAP values were compared with the respective histological and macroscopic evaluation and correlated with clinical parameters. Results CAP values > 300 dB/m had an 87.5 % specificity for detection of hepatic steatosis but failed to discriminate between steatosis grade S1 – S3. Discordant results, defined as a discrepancy of at least 2 steatosis grades between transient elastography and liver biopsy, were observed in 40 % of cases. The interquartile range (IQR) of CAP was confirmed as a predictor of discrepant findings. Macroscopic evaluation as part of minilaparoscopy detected hepatic steatosis in 74 % of patients with histological grade S2 – S3 in contrast to only 10 % classified as histological grade S0 – S1. Conclusion High CAP measurements need to be interpreted with care and with regard to clinical parameters, in particular when high IQR values are registered.

Hepatic steatosis as measured by the computed attenuation parameter predicts fibrosis in long-term methotrexate use

2021 ◽  
pp. e20200040
Author(s):  
Marcel Tomaszewski ◽  
Monica Dahiya ◽  
Seyed Amir Mohajerani ◽  
Hanaa Punja ◽  
Hin Hin Ko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regression Analysis ◽  
Hepatic Steatosis ◽  
Multivariate Regression ◽  
Transient Elastography ◽  
Multivariate Regression Analysis ◽  
Attenuation Parameter ◽  
Dermatologic Disease ◽  
Severe Fibrosis

Introduction: To determine predictors of hepatic steatosis by the computed attenuation parameter (CAP) and fibrosis via transient elastography (TE) in persons on methotrexate (MTX) therapy with rheumatologic and dermatologic diseases. Methods: A single-centred retrospective cohort study was performed. Patients on >6 months of MTX for a rheumatologic or dermatologic disease who had undergone TE from January 2015 to September 2019 were included. Multivariate analysis was performed to determine predictors of steatosis and fibrosis. Results: A total of 172 patients on methotrexate were included. Psoriasis was the most frequent diagnosis ( n = 55), followed by rheumatoid arthritis ( n = 45) and psoriatic arthritis ( n = 34). Steatosis (CAP ≥245 dB/m) was present in 69.8% of patients. Multivariate regression analysis revealed that diabetes mellitus (OR 10.47, 95% CI 1.42–75.35), hypertension (OR 5.15, 95% CI 1.75–15.38), and BMI ≥30 kg/m2 (OR 16.47, 95% CI 5.56–45.56) were predictors of steatosis (CAP ≥245 dB/m). Predictors of moderate to severe fibrosis (Metavir ≥F2 = TE ≥8.0kPa) by multivariate regression analysis included moderate to severe steatosis (CAP ≥270 dB/m) (OR 8.36, 95% CI 1.88–37.14), diabetes mellitus (OR 2.85, 95% CI 1.09–7.48), hypertension (OR 5.4, 95% CI 2.23–13.00), dyslipidemia (OR 3.71, 95% CI 1.50–9.18), and moderate alcohol use (OR 3.06, 95% CI 1.2–7.49). Conclusions: In patients on MTX for rheumatologic and dermatologic diseases, hepatic steatosis as measured by CAP was common and moderate to severe steatosis predicted moderate to severe fibrosis.

Open-label Study with Nalmefene as Needed Use in Alcohol-Dependent Patients with Evidence of Elevated Liver Stiffness and/or Hepatic Steatosis

2019 ◽  
Author(s):  
Sebastian Mueller ◽  
Mathias Luderer ◽  
Doris Zhang ◽  
Didier Meulien ◽  
Björn Steiniger Brach ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Heavy Drinking ◽  
Liver Stiffness ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Liver Parameters

Abstract Aims This open-label study in patients with alcohol dependence and evidence of elevated liver stiffness and/or hepatic steatosis was designed to explore the efficacy of nalmefene (18 mg) in reducing alcohol consumption and its subsequent effects on a variety of clinically relevant liver parameters. Methods Adult patients with a diagnosis of alcohol dependence and evidence of elevated liver stiffness and/or hepatic steatosis (liver stiffness >6 kPa or controlled attenuation parameter (CAP) >215 dB/m as measured by transient elastography) were recruited at two study sites in Germany. During the 12-week treatment period, patients were instructed to take nalmefene each day they perceived a risk of drinking alcohol. Results All 45 enrolled patients took at least one dose of nalmefene and 39 completed the study. After 12 weeks of study treatment with nalmefene patients showed a reduction in alcohol consumption of −13.5 days/month heavy drinking days and −45.8 g/day total alcohol consumption. Most liver parameters showed modest changes at Week 12; there was a 13% decrease in liver stiffness and 10% reduction in CAP values. Results indicated non-significant negative associations between alcohol consumption and liver stiffness and/or CAP over this 12-week study. Nalmefene was generally well tolerated, and most adverse events were mild or moderate, the most frequent being dizziness. Conclusions Patients treated with nalmefene for 12 weeks had reductions in alcohol consumption by ~50% relative to baseline and showed trends to improvement in liver stiffness and CAP.

scholarly journals Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Francesco Paparo ◽  
Giovanni Cenderello ◽  
Matteo Revelli ◽  
Lorenzo Bacigalupo ◽  
Mariangela Rutigliani ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Diagnostic Accuracy ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Liver Steatosis ◽  
Liver Stiffness ◽  
Diagnostic Value ◽  
Proton Density ◽  
Time Interval ◽  
Fat Fraction

Objective.To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard.Methods.Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days.Results.Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18–81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r=0.754, 95% CI 0.637 to 0.836,P<0.0001), and the correlation was influenced by neither the liver stiffness nor the T2*decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P<0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) forS≥1and 0.929 (95% CI 0.847 to 0.975) forS=2.Conclusions.Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.

Sign in / Sign up

Export Citation Format

Share Document