1331-P: OGTT Glucose-Response-Curve (GRC) in Islet Cell Antibody-Positive (Ab+) vs. -Negative (Ab-) Obese Youth Clinically Diagnosed with Type 2 Diabetes (CDX-T2D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1331-P
Author(s):  
JOON YOUNG KIM ◽  
NOUR GEBARA ◽  
HALA TFAYLI ◽  
FIDA BACHA ◽  
SILVA A. ARSLANIAN
Keyword(s):  
Type 2 Diabetes ◽  
Islet Cell ◽  
Response Curve ◽  
Islet Cell Antibody ◽  
Glucose Response ◽  
Obese Youth ◽  
Cell Antibody

scholarly journals Phenotypic Type 2 Diabetes in Obese Youth: Insulin Sensitivity and Secretion in Islet Cell Antibody-Negative Versus -Positive Patients

Diabetes ◽  
2008 ◽  
Vol 58 (3) ◽  
pp. 738-744 ◽  
Author(s):  
H. Tfayli ◽  
F. Bacha ◽  
N. Gungor ◽  
S. Arslanian
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Islet Cell ◽  
Islet Cell Antibody ◽  
Obese Youth ◽  
Cell Antibody

scholarly journals The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth

Diabetes Care ◽  
2016 ◽  
Vol 39 (8) ◽  
pp. 1431-1439 ◽  
Author(s):  
Joon Young Kim ◽  
Sara F. Michaliszyn ◽  
Alexis Nasr ◽  
SoJung Lee ◽  
Hala Tfayli ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Response Curve ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Glucose Response ◽  
Obese Youth

scholarly journals Glucose Response Curve and Type 2 Diabetes Risk in Latino Adolescents

Diabetes Care ◽  
2012 ◽  
Vol 35 (9) ◽  
pp. 1925-1930 ◽  
Author(s):  
J. Y. Kim ◽  
D. K. Coletta ◽  
L. J. Mandarino ◽  
G. Q. Shaibi
Keyword(s):  
Type 2 Diabetes ◽  
Response Curve ◽  
Diabetes Risk ◽  
Latino Adolescents ◽  
Glucose Response

scholarly journals Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin

2021 ◽  
Vol 9 (1) ◽  
pp. e002264
Author(s):  
Kristina M Utzschneider ◽  
Naji Younes ◽  
Neda Rasouli ◽  
Joshua I Barzilay ◽  
Mary Ann Banerji ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Response Curve ◽  
Cell Function ◽  
Curve Shape ◽  
Β Cell ◽  
Glucose Response ◽  
C Peptide ◽  
Β Cell Function ◽  
Early Late

IntroductionThe shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.Research design and methodsThis is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed <10 years who underwent 2-hour 75 g OGTT at baseline as part of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Insulin sensitivity (homeostasis model of insulin sensitivity, HOMA2-S) and β-cell function (early, late, and total incremental insulin and C peptide responses adjusted for HOMA2-S) were calculated. Glucose curve shape was classified as monophasic, biphasic, or continuous rise.ResultsThe monophasic profile was the most common (67.8% monophasic, 5.5% biphasic, 26.7% continuous rise). The monophasic subgroup was younger, more likely male and white, and had higher body mass index (BMI), while the continuous rise subgroup was more likely female and African American/black. HOMA2-S and fasting glucose did not differ among the subgroups. The biphasic subgroup had the highest early, late, and total insulin and C peptide responses (all p<0.05 vs monophasic and continuous rise). Compared with the monophasic subgroup, the continuous rise subgroup had similar early insulin (p=0.3) and C peptide (p=0.6) responses but lower late insulin (p<0.001) and total insulin (p=0.008) and C peptide (p<0.001) responses.ConclusionsBased on the large multiethnic GRADE cohort, sex, race, age, and BMI were found to be important determinants of the shape of the glucose response curve. A pattern of a continuously rising glucose at 2 hours reflected reduced β-cell function and may portend increased glycemic failure rates.Trial registration numberNCT01794143.

1746-P: Obese Youth with Type 1 Diabetes (T1D) Have Worse Hepatic Insulin Resistance (IR) Than Youth with Type 2 Diabetes (T2D)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1746-P
Author(s):  
PATTARA WIROMRAT ◽  
MELANIE CREE-GREEN ◽  
BRYAN C. BERGMAN ◽  
KALIE L. TOMMERDAHL ◽  
AMY BAUMGARTNER ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Hepatic Insulin Resistance ◽  
Obese Youth

Relation between insulin antibody and complement-fixing islet cell antibody at clinical diagnosis of IDDM

Diabetes ◽  
1986 ◽  
Vol 35 (5) ◽  
pp. 620-622 ◽  
Author(s):  
J. Karjalainen ◽  
M. Knip ◽  
A. Mustonen ◽  
J. Ilonen ◽  
H. K. Akerblom
Keyword(s):  
Clinical Diagnosis ◽  
Islet Cell ◽  
Islet Cell Antibody ◽  
Insulin Antibody ◽  
Cell Antibody

Islet cell proteins defined by monoclonal islet cell antibody HISL-19

Diabetes ◽  
1986 ◽  
Vol 35 (3) ◽  
pp. 300-305 ◽  
Author(s):  
S. Srikanta ◽  
K. Krisch ◽  
G. S. Eisenbarth
Keyword(s):  
Islet Cell ◽  
Islet Cell Antibody ◽  
Cell Antibody
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