167-OR: Activation of Myocardial Mitochondria Akt1 Improved Diabetic Cardiomyopathy and Body Composition—The Heart as a Metabolic Organ

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 167-OR
Author(s):  
YU-HAN CHEN ◽  
ALBERT TA ◽  
HSIAOCHEN LEE ◽  
HUGO YOU-HSIEN LIN ◽  
YUMAY CHEN ◽  
...  
Keyword(s):  
Body Composition ◽  
Diabetic Cardiomyopathy ◽  
Myocardial Mitochondria

scholarly journals Characterisation of the Myocardial Mitochondria Structural and Functional Phenotype in a Murine Model of Diabetic Cardiomyopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Alex M. Parker ◽  
Mitchel Tate ◽  
Darnel Prakoso ◽  
Minh Deo ◽  
Andrew M. Willis ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Low Dose ◽  
Body Weight Gain ◽  
Left Ventricular ◽  
Complex Iii ◽  
Diabetic Mice ◽  
High Fat ◽  
V Protein ◽  
Myocardial Mitochondria ◽  
Increased Risk

People affected by diabetes are at an increased risk of developing heart failure than their non-diabetic counterparts, attributed in part to a distinct cardiac pathology termed diabetic cardiomyopathy. Mitochondrial dysfunction and excess reactive oxygen species (ROS) have been implicated in a range of diabetic complications and are a common feature of the diabetic heart. In this study, we sought to characterise impairments in mitochondrial structure and function in a recently described experimental mouse model of diabetic cardiomyopathy. Diabetes was induced in 6-week-old male FVB/N mice by the combination of three consecutive-daily injections of low-dose streptozotocin (STZ, each 55 mg/kg i.p.) and high-fat diet (42% fat from lipids) for 26 weeks. At study end, diabetic mice exhibited elevated blood glucose levels and impaired glucose tolerance, together with increases in both body weight gain and fat mass, replicating several aspects of human type 2 diabetes. The myocardial phenotype of diabetic mice included increased myocardial fibrosis and left ventricular (LV) diastolic dysfunction. Elevated LV superoxide levels were also evident. Diabetic mice exhibited a spectrum of LV mitochondrial changes, including decreased mitochondria area, increased levels of mitochondrial complex-III and complex-V protein abundance, and reduced complex-II oxygen consumption. In conclusion, these data suggest that the low-dose STZ-high fat experimental model replicates some of the mitochondrial changes seen in diabetes, and as such, this model may be useful to study treatments that target the mitochondria in diabetes.

Characterising the Myocardial Mitochondria Phenotype in a Murine Model of Diabetic Cardiomyopathy

2021 ◽  
Vol 30 ◽  
pp. S118
Author(s):  
A. Parker ◽  
M. Tate ◽  
D. Prakoso ◽  
M. Deo ◽  
A. Willis ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Murine Model ◽  
Myocardial Mitochondria

Physical activity and body composition of adolescent boys

JAMA ◽  
1966 ◽  
Vol 197 (11) ◽  
pp. 891-893 ◽  
Author(s):  
L. P. Novak
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Adolescent Boys

The effect of liver cirrhosis on body composition in a Brazilian sample

2001 ◽  
Vol 120 (5) ◽  
pp. A262-A262
Author(s):  
F FIGUEIREDO ◽  
M KONDO ◽  
M CHARLTON
Keyword(s):  
Body Composition ◽  
Liver Cirrhosis ◽  
Brazilian Sample

514 Prognostic significance of bioelectrical evaluation of body composition in chronic heart failure

2003 ◽  
Vol 2 (1) ◽  
pp. 105
Author(s):  
F MASSARI ◽  
P GUIDA ◽  
F MASTROPASQUA ◽  
M IACOVIELLO ◽  
B RIZZON ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Composition ◽  
Chronic Heart Failure ◽  
Prognostic Significance

The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

2018 ◽  
Vol 88 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
Zahra Shakibay Novin ◽  
Saeed Ghavamzadeh ◽  
Alireza Mehdizadeh
Keyword(s):  
Amino Acids ◽  
Weight Loss ◽  
Body Composition ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Waist To Hip Ratio ◽  
Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

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