2169-P: A Gene Expression Network Analysis of the Pancreatic Islets from Lean and Obese Mice Identifies Complement 1q-Like-3 Secreted Protein as a Regulator of Beta-Cell Function

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2169-P
Author(s):  
JAMES KOLTES ◽  
ITIKA ARORA ◽  
RAJESH GUPTA ◽  
DAN C. NGUYEN ◽  
SUSHANT BHATNAGAR
Keyword(s):  
Gene Expression ◽  
Network Analysis ◽  
Beta Cell ◽  
Pancreatic Islets ◽  
Beta Cell Function ◽  
Cell Function ◽  
Secreted Protein ◽  
Obese Mice ◽  
Gene Expression Network

scholarly journals The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Trine Maxel ◽  
Kamille Smidt ◽  
Charlotte C. Petersen ◽  
Bent Honoré ◽  
Anne K. Christensen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Secretion ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Zinc Transporter

scholarly journals EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes

2007 ◽  
Vol 35 (Database) ◽  
pp. D751-D755 ◽  
Author(s):  
J. M. Mazzarelli ◽  
J. Brestelli ◽  
R. K. Gorski ◽  
J. Liu ◽  
E. Manduchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Development ◽  
Web Resource

scholarly journals d-Glyceraldehyde Causes Production of Intracellular Peroxide in Pancreatic Islets, Oxidative Stress, and Defective Beta Cell Function via Non-mitochondrial Pathways

2004 ◽  
Vol 279 (36) ◽  
pp. 37316-37323 ◽  
Author(s):  
Hiroki Takahashi ◽  
Phuong Oanh T. Tran ◽  
Eric LeRoy ◽  
Jamie S. Harmon ◽  
Yoshito Tanaka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Pancreatic Islets ◽  
Beta Cell Function ◽  
Cell Function

scholarly journals MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 534
Author(s):  
Jamie M. R. Tarlton ◽  
Steven Patterson ◽  
Annette Graham
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Lipid Metabolism ◽  
Beta Cell ◽  
Beta Cells ◽  
Beta Cell Function ◽  
Cell Function ◽  
Therapeutic Strategies ◽  
Predictive Analysis

Alterations in lipid metabolism within beta cells and islets contributes to dysfunction and apoptosis of beta cells, leading to loss of insulin secretion and the onset of type 2 diabetes. Over the last decade, there has been an explosion of interest in understanding the landscape of gene expression which influences beta cell function, including the importance of small non-coding microRNA sequences in this context. This review sought to identify the microRNA sequences regulated by metabolic challenges in beta cells and islets, their targets, highlight their function and assess their possible relevance as biomarkers of disease progression in diabetic individuals. Predictive analysis was used to explore networks of genes targeted by these microRNA sequences, which may offer new therapeutic strategies to protect beta cell function and delay the onset of type 2 diabetes.

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