Inhibition of SGLT-2 rescues bone marrow cell traffic for vascular repair. Role of glucose control and ketogenesis

Diabetes ◽  
2021 ◽  
pp. db201045
Author(s):  
Mattia Albiero ◽  
Serena Tedesco ◽  
Francesco Ivan Amendolagine ◽  
Marianna D'Anna ◽  
Ludovica Migliozzi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cell ◽  
Glucose Control ◽  
Marrow Cell ◽  
Vascular Repair

Sex-Based Differences in Vascular Repair With Bone Marrow Cell Therapy: Relevance of Regulatory and Th2-type Cytokines

2008 ◽  
Vol 40 (2) ◽  
pp. 641-643 ◽  
Author(s):  
A.G. Zenovich ◽  
A. Panoskaltsis-Mortari ◽  
G.J. Caron ◽  
A.G. Kolb ◽  
R. Fremming ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Therapy ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Vascular Repair ◽  
Bone Marrow Cell Therapy

An apoptotic endonuclease activated either by decreasing pH or by increasing calcium

1996 ◽  
Vol 109 (9) ◽  
pp. 2393-2399 ◽  
Author(s):  
M.K. Collins ◽  
I.J. Furlong ◽  
P. Malde ◽  
R. Ascaso ◽  
J. Oliver ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Line ◽  
Dna Fragmentation ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Isolated Nuclei ◽  
Neutral Ph ◽  
Decreasing Ph

DNA fragmentation in isolated nuclei from the murine IL3-dependent bone marrow cell line BAF3 could be stimulated either by decreasing pH below 6.5 or by adding microM calcium at neutral pH. An endonuclease which could also be stimulated either by a decrease in pH, to 6.5, or by the presence of microM calcium at neutral pH, was purified 10(4)-fold from nuclei of BAF3 cells. Digestion of DNA with the purified enzyme resulted in 5′-terminal hydroxyl and 3′-terminal phosphate ends. These characteristics are distinct from those described for other mammalian endonucleases. The possible role of this enzyme in genome digestion during apoptosis is discussed.

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