496-P: Large-Scale Association of Basal Metabolic Rate and Blood Glucose Outcomes in People with Type 2 Diabetes

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 496-P
Author(s):  
YDO WEXLER ◽  
DAN GOLDNER
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Large Scale

scholarly journals Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes

2020 ◽  
Vol 8 (1) ◽  
pp. e001381
Author(s):  
Sebastian Maciak ◽  
Diana Sawicka ◽  
Anna Sadowska ◽  
Sławomir Prokopiuk ◽  
Sylwia Buczyńska ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Risk Factor ◽  
Blood Glucose ◽  
Metabolic Rate ◽  
Body Mass ◽  
Basal Metabolic Rate ◽  
High Fat Diet ◽  
High Fat

IntroductionIdentification of physiological factors influencing susceptibility to insulin resistance and type 2 diabetes (T2D) remains an important challenge for biology and medicine. Numerous studies reported energy expenditures as one of those components directly linked to T2D, with noticeable increase of basal metabolic rate (BMR) associated with the progression of insulin resistance. Conversely, the putative link between genetic, rather than phenotypic, determination of BMR and predisposition to development of T2D remains little studied. In particular, low BMR may constitute a considerable risk factor predisposing to development of T2D.Research design and methodsWe analyzed the development of insulin resistance and T2D in 20-week-old male laboratory mice originating from three independent genetic line types. Two of those lines were subjected to divergent, non-replicated selection towards high or low body mass-corrected BMR. The third line type was non-selected and consisted of randomly bred animals serving as an outgroup (reference) to the selected line types. To induce insulin resistance, mice were fed for 8 weeks with a high fat diet; the T2D was induced by injection with a single dose of streptozotocin and further promotion with high fat diet. As markers for insulin resistance and T2D advancement, we followed the changes in body mass, fasting blood glucose, insulin level, lipid profile and mTOR expression.ResultsWe found BMR-associated differentiation in standard diabetic indexes between studied metabolic lines. In particular, mice with low BMR were characterized by faster body mass gain, blood glucose gain and deterioration in lipid profile. In contrast, high BMR mice were characterized by markedly higher expression of the mTOR, which may be associated with much slower development of T2D.ConclusionsOur study suggests that genetically determined low BMR makeup involves metabolism-specific pathways increasing the risk of development of insulin resistance and T2D.

scholarly journals Body Composition and Basal Metabolic Rate in Women with Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Marina de Figueiredo Ferreira ◽  
Filipe Detrano ◽  
Gabriela Morgado de Oliveira Coelho ◽  
Maria Elisa Barros ◽  
Regina Serrão Lanzillotti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Composition ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Adult Women ◽  
Cross Sectional ◽  
Significant Difference

Objective.The aim of this study was to determine which of the seven selected equations used to predict basal metabolic rate most accurately estimated the measured basal metabolic rate.Methods.Twenty-eight adult women with type 2 diabetes mellitus participated in this cross-sectional study. Anthropometric and biochemical variables were measured as well as body composition (by absorptiometry dual X-ray emission) and basal metabolic rate (by indirect calorimetry); basal metabolic rate was also estimated by prediction equations.Results.There was a significant difference between the measured and the estimated basal metabolic rate determined by the FAO/WHO/UNU(Pvalue<0.021)and Huang et al.(Pvalue≤0.005)equations.Conclusion.The calculations using Owen et al’s. equation were the closest to the measured basal metabolic rate.

scholarly journals Large-scale survey of rates of achieving targets for blood glucose, blood pressure, and lipids and prevalence of complications in type 2 diabetes (JDDM 40)

2016 ◽  
Vol 4 (1) ◽  
pp. e000294 ◽  
Author(s):  
Hiroki Yokoyama ◽  
Mariko Oishi ◽  
Hiroshi Takamura ◽  
Katsuya Yamasaki ◽  
Shin-ichiro Shirabe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Large Scale ◽  
Large Scale Survey

scholarly journals Basal metabolic rate in Brazilian patients with type 2 diabetes: comparison between measured and estimated values

2019 ◽  
Vol 63 (1) ◽  
pp. 53-61
Author(s):  
Thais Steemburgo ◽  
Camila Lazzari ◽  
Juliano Boufleur Farinha ◽  
Tatiana Pedroso de Paula ◽  
Luciana Vercoza Viana ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Rate ◽  
Basal Metabolic Rate

Caffeine and glucose homeostasis during rest and exercise in diabetes mellitus

2013 ◽  
Vol 38 (8) ◽  
pp. 813-822 ◽  
Author(s):  
Dessi P. Zaharieva ◽  
Michael C. Riddell
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Homeostasis ◽  
Large Scale ◽  
Blood Glucose Concentration ◽  
Warning Signs ◽  
Glucose Disposal ◽  
Caffeine Intake ◽  
Rest And Exercise

Caffeine is a substance that has been used in our society for generations, primarily for its effects on the central nervous system that causes wakefulness. Caffeine supplementation has become increasingly more popular as an ergogenic aid for athletes and considerable scientific evidence supports its effectiveness. Because of their potential to alter energy metabolism, the effects of coffee and caffeine on glucose metabolism in diabetes have also been studied both epidemiologically and experimentally. Predominantly targeting the adenosine receptors, caffeine causes alterations in glucose homeostasis by decreasing glucose uptake into skeletal muscle, thereby causing elevations in blood glucose concentration. Caffeine intake has also been proposed to increase symptomatic warning signs of hypoglycemia in patients with type 1 diabetes and elevate blood glucose levels in patients with type 2 diabetes. Other effects include potential increases in glucose counterregulatory hormones such as epinephrine, which can also decrease peripheral glucose disposal. Despite these established physiological effects, increased coffee intake has been associated with reduced risk of developing type 2 diabetes in large-scale epidemiological studies. This review paper highlights the known effects of caffeine on glucose homeostasis and diabetes metabolism during rest and exercise.

The relationship between intertemporal choice and blood glucose control in type 2 diabetes

2018 ◽  
Author(s):  
Hyun Ju Lee ◽  
Mi-Kyung Kim ◽  
Yang Tae Kim ◽  
Hye soon Kim ◽  
Nan Hee Cho
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Control ◽  
Intertemporal Choice ◽  
Blood Glucose Control ◽  
The Relationship
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