52-OR: Risk Factors and Incidence over Time for Lower Extremity Amputations in Persons with Type 1 Diabetes: An Observational Cohort Study of 46,008 Patients from the Swedish National Diabetes Registry

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 52-OR
Author(s):  
SARA HALLSTRÖM ◽  
ANN-MARIE SVENSSON ◽  
ALDINA PIVODIC ◽  
ARNDIS F. OLAFSDOTTIR ◽  
MAGNUS LONDAHL ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Lower Extremity ◽  
Observational Cohort Study ◽  
Diabetes Registry ◽  
Observational Cohort ◽  
Over Time

scholarly journals Risk Factors for Atrial Fibrillation in People With Type 1 Diabetes: An Observational Cohort Study of 36,258 Patients From the Swedish National Diabetes Registry

Diabetes Care ◽  
2019 ◽  
Vol 42 (8) ◽  
pp. 1530-1538 ◽  
Author(s):  
Sara Hallström ◽  
Aldina Pivodic ◽  
Annika Rosengren ◽  
Arndís F. Ólafsdóttir ◽  
Ann-Marie Svensson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Diabetes Registry ◽  
Observational Cohort

scholarly journals Risk factors and incidence over time for lower extremity amputations in people with type 1 diabetes: an observational cohort study of 46,088 patients from the Swedish National Diabetes Registry

Diabetologia ◽  
2021 ◽  
Author(s):  
Sara Hallström ◽  
Ann-Marie Svensson ◽  
Aldina Pivodic ◽  
Arndís F. Ólafsdóttir ◽  
Magnus Löndahl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Lower Extremity ◽  
Renal Dysfunction ◽  
Diabetes Registry ◽  
Male Sex ◽  
The Impact ◽  
Over Time ◽  
Age And Sex

Abstract Aims/hypothesis The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. Methods Individuals with type 1 diabetes registered in the Swedish National Diabetes Registry with no previous amputation from 1 January 1998 and followed to 2 October 2019 were included. Time-updated Cox regression and gradient of risk per SD were used to evaluate the impact of risk factors on the incidence of amputation. Age- and sex-adjusted incidences were estimated over time. Results Of 46,088 people with type 1 diabetes with no previous amputation (mean age 32.5 years [SD 14.5], 25,354 [55%] male sex), 1519 (3.3%) underwent amputation. Median follow-up was 12.4 years. The standardised incidence for any amputation in 1998–2001 was 2.84 (95% CI 2.32, 3.36) per 1000 person-years and decreased to 1.64 (95% CI 1.38, 1.90) per 1000 person-years in 2017–2019. The incidence for minor and major amputations showed a similar pattern. Hyperglycaemia and renal dysfunction were the strongest risk factors for amputation, followed by older age, male sex, cardiovascular comorbidities, smoking and hypertension. Glycaemic control and age- and sex-adjusted renal function improved during the corresponding time period as amputations decreased. Conclusions/interpretation The incidence of amputation and of the most prominent risk factors for amputation, including renal dysfunction and hyperglycaemia, has improved considerably during recent years for people with type 1 diabetes. This finding has important implications for quality of life, health economics and prognosis regarding CVD, indicating a trend shift in the treatment of type 1 diabetes. Graphical abstract

scholarly journals Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies

Diabetologia ◽  
2019 ◽  
Vol 62 (7) ◽  
pp. 1143-1153 ◽  
Author(s):  
Karl Kristensen ◽  
Linda E. Ögge ◽  
Verena Sengpiel ◽  
Karin Kjölhede ◽  
Annika Dotevall ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Pregnant Women ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Observational Cohort Study ◽  
Observational Cohort

scholarly journals Clinical Effects and Safety of Direct-Acting Insulin Analogs in Patients with Type 1 Diabetes: A Nation-Wide Observational Cohort Study

2016 ◽  
Vol 7 (3) ◽  
pp. 561-573 ◽  
Author(s):  
Vincent Lak ◽  
Ann-Marie Svensson ◽  
Mervete Miftaraj ◽  
Stefan Franzén ◽  
Björn Eliasson
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Clinical Effects ◽  
Insulin Analogs ◽  
Acting Insulin ◽  
Observational Cohort ◽  
Direct Acting
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