scholarly journals Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes: The BABYDIET study

Diabetes Care ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 1301-1305 ◽  
Author(s):  
S. Hummel ◽  
M. Pfluger ◽  
M. Hummel ◽  
E. Bonifacio ◽  
A.-G. Ziegler
Keyword(s):  
Type 1 Diabetes ◽  
Intervention Study ◽  
Dietary Intervention ◽  
Islet Autoimmunity ◽  
Dietary Intervention Study ◽  
Increased Risk

Associations of growth patterns and islet autoimmunity in children with increased risk for type 1 diabetes: a functional analysis approach

2016 ◽  
Vol 18 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Christina Yassouridis ◽  
Friedrich Leisch ◽  
Christiane Winkler ◽  
Anette-Gabriele Ziegler ◽  
Andreas Beyerlein
Keyword(s):  
Functional Analysis ◽  
Type 1 Diabetes ◽  
Growth Patterns ◽  
Analysis Approach ◽  
Islet Autoimmunity ◽  
Increased Risk

scholarly journals Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study

Diabetologia ◽  
2019 ◽  
Vol 63 (2) ◽  
pp. 278-286 ◽  
Author(s):  
Markus Mattila ◽  
◽  
Iris Erlund ◽  
Hye-Seung Lee ◽  
Sari Niinistö ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Type 1 Diabetes ◽  
Vitamin C ◽  
Data Availability ◽  
Islet Autoimmunity ◽  
Plasma Ascorbic Acid ◽  
Background Population ◽  
Increased Risk ◽  
Nested Case Control

Abstract Aims/hypothesis We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification. Results Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). Conclusions/interpretation Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. Data availability The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy.

scholarly journals Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children

Diabetologia ◽  
2017 ◽  
Vol 61 (1) ◽  
pp. 193-202 ◽  
Author(s):  
Helena Elding Larsson ◽  
◽  
Kristian F. Lynch ◽  
Maria Lönnrot ◽  
Michael J. Haller ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Autoimmunity ◽  
Increased Risk

scholarly journals Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Brittni N. Frederiksen ◽  
Andrea K. Steck ◽  
Miranda Kroehl ◽  
Molly M. Lamb ◽  
Randall Wong ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cox Regression ◽  
Islet Autoimmunity ◽  
Candidate Snps ◽  
Age Related ◽  
Increased Risk ◽  
Restricted Cubic Splines ◽  
Candidate Loci ◽  
Hispanic White

Previously, we examined 20 non-HLA SNPs for association with islet autoimmunity (IA) and/or progression to type 1 diabetes (T1D). Our objective was to investigate fourteen additional non-HLA T1D candidate SNPs for stage- and age-related heterogeneity in the etiology of T1D. Of 1634 non-Hispanic white DAISY children genotyped, 132 developed IA (positive for GAD, insulin, or IA-2 autoantibodies at two or more consecutive visits); 50 IA positive children progressed to T1D. Cox regression was used to analyze risk of IA and progression to T1D in IA positive children. Restricted cubic splines were used to model SNPs when there was evidence that risk was not constant with age.C1QTNF6(rs229541) predicted increased IA risk (HR: 1.57, CI: 1.20–2.05) but not progression to T1D (HR: 1.13, CI: 0.75–1.71). SNP (rs10517086) appears to exhibit an age-related effect on risk of IA, with increased risk before age 2 years (age 2 HR: 1.67, CI: 1.08–2.56) but not older ages (age 4 HR: 0.84, CI: 0.43–1.62).C1QTNF6(rs229541), SNP (rs10517086), andUBASH3A(rs3788013) were associated with development of T1D. This prospective investigation of non-HLA T1D candidate loci shows that some SNPs may exhibit stage- and age-related heterogeneity in the etiology of T1D.

scholarly journals Association between change in self-reported sugar intake and a sugar biomarker (δ13C) in children at increased risk for type 1 diabetes

2020 ◽  
Vol 9 ◽  
Author(s):  
Martha M. Henze ◽  
Elizabeth A. Bemis ◽  
Jennifer A. Seifert ◽  
Randi K. Johnson ◽  
Fran Dong ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Prospective Cohort ◽  
Intervention Study ◽  
Added Sugar ◽  
Sugar Intake ◽  
Time Points ◽  
Increased Risk ◽  
Dietary Sugar

Abstract We examined whether change in added sugar intake is associated with change in δ13C, a novel sugar biomarker, in thirty-nine children aged 5–10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δ13C in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake was associated with change in the δ13C biomarker, where for every 1-g increase in added sugar intake between the two time points, there was an increase in δ13C of 0⋅0082 (P = 0⋅0053), independent of change in HbA1c and δ15N. The δ13C biomarker may be used as a measure of compliance in an intervention study of children under the age of 10 years who are at increased risk for type 1 diabetes, in which the goal was to reduce dietary sugar intake.

scholarly journals Autoantibodies to N-Terminally Truncated GAD65(96–585): HLA Associations and Predictive Value for Type 1 Diabetes

2021 ◽  
Author(s):  
Petra M Pöllänen ◽  
Taina Härkönen ◽  
Jorma Ilonen ◽  
Jorma Toppari ◽  
Riitta Veijola ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Predictive Value ◽  
Dietary Intervention ◽  
Venous Blood ◽  
Islet Cell Antibodies ◽  
Acid Decarboxylase ◽  
Prediction And Prevention ◽  
Increased Risk ◽  
Combining Data

Abstract Objective To evaluate the role of autoantibodies to N-terminally truncated glutamic acid decarboxylase GAD65(96–585) (t-GADA) as a marker for type 1 diabetes (T1D) and to assess the potential HLA-associations with such autoantibodies. Design In this cross-sectional study combining data from the Finnish Pediatric Diabetes Register, the Type 1 Diabetes Prediction and Prevention (DIPP) Study, the DIABIMMUNE Study, and the Early Dietary Intervention and Later Signs of Beta-Cell Autoimmunity (EDIA) Study, venous blood samples from 760 individuals (53.7% males) were analyzed for t-GADA, autoantibodies to full-length GAD65 (f-GADA), and islet cell antibodies. Epitope-specific GAD autoantibodies were analyzed from 189 study participants. Results T1D had been diagnosed in 174 (23%) participants. Altogether 631 (83%) individuals tested positive for f-GADA and 451 (59%) for t-GADA at a median age of 9.0 years (range 0.2–61.5). t-GADA demonstrated higher specificity (46%) and positive predictive value (30%) for T1D than positivity for f-GADA alone (15% and 21%, respectively). Among participants positive for f-GADA, those who tested positive for t-GADA carried more frequently HLA genotypes conferring increased risk for T1D than those who tested negative for t-GADA (77 vs. 53%; P<0.001). Conclusions Autoantibodies to N-terminally truncated GAD improve the screening for T1D compared to f-GADA and may facilitate the selection of participants for clinical trials. HLA class II-mediated antigen presentation of GAD(96–585)-derived or structurally similar peptides might comprise an important pathomechanism in T1D.

Omega-3 Polyunsaturated Fatty Acid Intake and Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes

JAMA ◽  
2007 ◽  
Vol 298 (12) ◽  
pp. 1420 ◽  
Author(s):  
Jill M. Norris ◽  
Xiang Yin ◽  
Molly M. Lamb ◽  
Katherine Barriga ◽  
Jennifer Seifert ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Islet Autoimmunity ◽  
Fatty Acid Intake ◽  
Omega 3 ◽  
Acid Intake ◽  
Increased Risk

scholarly journals Gluten Intake and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in Children at Increased Risk of the Disease: The Diabetes Autoimmunity Study in the Young (DAISY)

Diabetes Care ◽  
2019 ◽  
Vol 42 (5) ◽  
pp. 789-796 ◽  
Author(s):  
Nicolai A. Lund-Blix ◽  
Fran Dong ◽  
Karl Mårild ◽  
Jennifer Seifert ◽  
Anna E. Barón ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Autoimmunity ◽  
Increased Risk

scholarly journals Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity

2020 ◽  
Vol 124 (2) ◽  
pp. 173-180
Author(s):  
Katariina Koivusaari ◽  
Essi Syrjälä ◽  
Sari Niinistö ◽  
Hanna-Mari Takkinen ◽  
Suvi Ahonen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Fermented Milk ◽  
Population Based ◽  
Food Composition ◽  
Islet Autoimmunity ◽  
Milk Consumption ◽  
Milk Products ◽  
Increased Risk ◽  
Fermented Milk Products

AbstractSeveral prospective studies have shown an association between cows’ milk consumption and the risk of islet autoimmunity and/or type 1 diabetes. We wanted to study whether processing of milk plays a role. A population-based birth cohort of 6081 children with HLA-DQB1-conferred risk to type 1 diabetes was followed until the age of 15 years. We included 5545 children in the analyses. Food records were completed at the ages of 3 and 6 months and 1, 2, 3, 4 and 6 years, and diabetes-associated autoantibodies were measured at 3–12-month intervals. For milk products in the food composition database, we used conventional and processing-based classifications. We analysed the data using a joint model for longitudinal and time-to-event data. By the age of 6 years, islet autoimmunity developed in 246 children. Consumption of all cows’ milk products together (energy-adjusted hazard ratio 1·06; 95 % CI 1·02, 1·11; P = 0·003), non-fermented milk products (1·06; 95 % CI 1·01, 1·10; P = 0·011) and fermented milk products (1·35; 95 % CI 1·10, 1·67; P = 0·005) was associated with an increased risk of islet autoimmunity. The early milk consumption was not associated with the risk beyond 6 years. We observed no clear differences based on milk homogenisation and heat treatment. Our results are consistent with the previous studies, which indicate that high milk consumption may cause islet autoimmunity in children at increased genetic risk. The study did not identify any specific type of milk processing that would clearly stand out as a sole risk factor apart from other milk products.

Gluten Intake and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in Children at Increased Risk of Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 136-OR ◽  
Author(s):  
NICOLAI A. LUND-BLIX ◽  
FRAN DONG ◽  
KARL MARILD ◽  
ANNA E. BARON ◽  
JENNIFER A. SEIFERT ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Autoimmunity ◽  
Increased Risk ◽  
Risk Of Disease
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