Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation

OBJECTIVE Total pancreatectomy with islet autotransplantation (TPIAT) is indicated to alleviate debilitating pancreas-related pain and mitigate diabetes in patients with acute recurrent and chronic pancreatitis when medical/endoscopic therapies fail. Our aim was to evaluate predictors of insulin requirement at 1 year following TPIAT in a cohort of children. RESEARCH DESIGN AND METHODS This was a review of 43 pediatric patients followed after TPIAT for 1 year or longer. Primary outcome was insulin use at 1 year, categorized as follows: insulin independent, low insulin requirement (<0.5 units/kg/day), or high insulin requirement (≥0.5 units/kg/day). RESULTS At 1 year after TPIAT, 12 of 41 (29%) patients were insulin independent and 21 of 41 (51%) had low and 8 of 41 (20%) had high insulin requirement. Insulin-independent patients were younger than those with low and high insulin requirement (median age 8.2 vs. 14.6 vs. 13.1 years, respectively; P = 0.03). Patients with insulin independence had a higher number of transplanted islet equivalents (IEQ) per kilogram body weight (P = 0.03) and smaller body surface area (P = 0.02), compared with those with insulin dependence. Preoperative exocrine insufficiency was associated with high insulin requirement (P = 0.03). Higher peak C-peptide measured by stimulated mixed-meal tolerance testing (MMTT) at 3 and 6 months post-TPIAT was predictive of lower insulin requirement at 1 year (P = 0.006 and 0.03, respectively). CONCLUSIONS We conclude that insulin independence following pediatric TPIAT is multifactorial and associated with younger age, higher IEQ per kilogram body weight transplanted, and smaller body surface area at time of operation. Higher peak C-peptide measured by MMTT following TPIAT confers a higher likelihood of low insulin requirement.

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Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation

10.2337/figshare.17072708 ◽

2022 ◽

Author(s):

Sarah E. Swauger ◽

Lindsey N. Hornung ◽

Deborah A. Elder ◽

Appakalai N. Balamurugan ◽

David S. Vitale ◽

...

Keyword(s):

Surface Area ◽

Body Surface ◽

Total Pancreatectomy ◽

Insulin Requirement ◽

Lower Body ◽

Insulin Independence ◽

C Peptide ◽

High Insulin ◽

Islet Autotransplantation ◽

One Year

Objective: Total pancreatectomy with islet autotransplantation (TPIAT) is indicated to alleviate debilitating pancreas-related pain and mitigate diabetes in patients with acute recurrent and chronic pancreatitis when medical/endoscopic therapies fail. Our aim was to evaluate predictors of insulin requirement at one year following TPIAT in a cohort of children. Research Design and Methods: This was a review of 43 pediatric patients followed after TPIAT for one year or longer. Primary outcome was insulin use at one year, categorized as: insulin independent, low (< 0.5 u/kg/day) or high insulin (≥ 0.5 u/kg/day) requirement. Results: At one year after TPIAT, 12/41 (29%) patients were insulin independent, 21/41 (51%) had low and 8/41 (20%) had high insulin requirement. Insulin independent patients were younger than those with low and high insulin requirement (median age 8.2 vs. 14.6 vs. 13.1 years, respectively; p=0.03). Patients with insulin independence had higher transplanted IEQ/kg (p=0.03) and lower body surface area (p=0.02), compared to those with insulin dependence. Preoperative exocrine insufficiency was associated with high insulin requirement (p=0.03). Higher peak C-peptide measured by stimulated mixed meal tolerance testing (MMTT) at 3 and 6 months post-TPIAT was predictive of lower insulin requirement at one year (p=0.006 and 0.03, respectively). Conclusions: We conclude that insulin independence following pediatric TPIAT is multifactorial and associated with younger age, higher IEQ/kg transplanted and lower body surface area at time of operation. Higher peak C-peptide measured by MMTT following TPIAT confers a higher likelihood of low insulin requirement.

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Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation

10.2337/figshare.17072708.v1 ◽

2022 ◽

Author(s):

Sarah E. Swauger ◽

Lindsey N. Hornung ◽

Deborah A. Elder ◽

Appakalai N. Balamurugan ◽

David S. Vitale ◽

...

Keyword(s):

Surface Area ◽

Body Surface ◽

Total Pancreatectomy ◽

Insulin Requirement ◽

Lower Body ◽

Insulin Independence ◽

C Peptide ◽

High Insulin ◽

Islet Autotransplantation ◽

One Year

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New formula for predicting standard liver and spleen volumes in Chinese adults

10.21203/rs.2.15790/v1 ◽

2019 ◽

Author(s):

Longbao Yang ◽

Gang Zhao ◽

Xinxing Tantai ◽

Cailan Xiao ◽

Caifeng Yang ◽

...

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Liver Volume ◽

Body Height ◽

Spleen Volume ◽

Chinese Adults ◽

Volume Formula

Abstract BACKGROUNDThe liver volume and spleen volum are useful index for cirrhosis patients with esphageal varices. But the calculation of the volume is time-consuming and boring. To solve the problem, we successfully established the liver and spleen volume formula using the body surface area. We compared the liver volume formula with other four formulas, which be proved with highest accuracy and lowest error. Until now, except for the new spleen volume formula in the research, there are few reports about it.AIMTo obtain a reference range of morphological indices, and to establish a formula to accurately predict the standard liver and spleen volumes in Chinese adults.METHODSComputed tomography was used to calculate the estimated total liver volume and spleen volume of 305 Chinese adults without any diseases which could influence the volumes of these two organs. Gender, age, body height, body weight, body surface area and body mass index were determined. Correlation analysis and step-wise multiple linear regression analysis were performed to evaluate the impact of each parameter on the liver and spleen volumes, and then a formula to predict the liver and spleen volumes was established. Finally, the results obtained with the new liver volume formula with existing formulas in a validation group were compared.RESULTSThe average liver and spleen volume values were 1043.18 ± 244.60 cm3 and 175.07 ± 88.15 cm3, respectively. Age, body height, body weight, body surface area and body mass index were significantly correlated with liver and spleen volume. Body surface area showed the strongest correlation with liver volume and spleen volume( p<0.005 and p<0.001). Based on these results, new formulas to calculate the standard liver volume and standard spleen volume were established.CONCLUSIONSCompared the new liver volume formula with the existing formula, it is found that the new liver volume is more accurate. And the accuracy of the spleen volume formula is acceptable. Core tip: To solve the problem of time-consuming and boring in calculating the liver and spleen volume, we successfully established the liver and spleen volume formula can be used in Chinese adult. Though there are some reports about the liver volume, but it is different in spleen volume. The liver volume and spleen volume radio is an useful index to predict the esophageal varices and bleeding risk for cirrhosis patients. Only liver volume formula is not enough, the finding of the spleen volume is very meaningful.

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Efficacy of body weight vs body surface area-based prednisolone regimen in nephrotic syndrome

Clinical and Experimental Nephrology ◽

10.1007/s10157-020-01875-y ◽

2020 ◽

Vol 24 (7) ◽

pp. 622-629 ◽

Cited By ~ 1

Author(s):

Biswanath Basu ◽

Suman Bhattacharyya ◽

Shilpita Barua ◽

Abhisek Naskar ◽

Birendranath Roy

Keyword(s):

Body Weight ◽

Nephrotic Syndrome ◽

Surface Area ◽

Body Surface Area ◽

Body Surface

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Changes in body weight and body surface area in strain 13 guinea pigs infected with pichinde virus

Life Sciences ◽

10.1016/0024-3205(89)90526-2 ◽

1989 ◽

Vol 44 (2) ◽

pp. 95-101 ◽

Cited By ~ 3

Author(s):

C.T. Liu

Keyword(s):

Body Weight ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Guinea Pigs ◽

Pichinde Virus

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Carbohydrate Metabolism of Hypophysectomized Dogs as Studied With Radioactive Glucose

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1956.187.1.25 ◽

1956 ◽

Vol 187 (1) ◽

pp. 25-31 ◽

Cited By ~ 28

Author(s):

R. Steele ◽

J. S. Wall ◽

R. C. de Bodo ◽

N. Altszuler

Keyword(s):

Body Weight ◽

Carbohydrate Metabolism ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Specific Activity ◽

Constant Infusion ◽

Minute Period ◽

Endogenous Glucose ◽

Low Rate

Minute amounts of uniformly labeled C14 glucose were administered intravenously to unanesthetized normal and hypophysectomized dogs, in the postabsorptive state, as an initial priming injection, followed by a constant infusion. From the observed specific activity of the plasma glucose during the 60–180-minute period of the constant infusion, the following parameters of carbohydrate metabolism were determined: a) the size of the glucose pool, b) the glucose space and c) the rate of turnover of the glucose pool. The rate of total CO2 production was also determined. The rate of total CO2 production, per square meter of body surface area, was found to be less in the hypophysectomized dog than in the normal one. The glucose pool, per kilogram body weight, was found to be smaller in the hypophysectomized dog than in the normal one. The glucose space, expressed as percentage of body weight, was found to be similar in the two types of animals. The rate of turnover of the glucose pool in the hypophysectomized dog, presented as grams glucose per square meter of body surface area per hour, was found to be less in the hypophysectomized dog than in the normal one. The low rate of glucose uptake by the tissues which was observed to prevail in the hypophysectomized dog is believed to reflect an adjustment in the secretion of insulin to conform to the limited availability of endogenous glucose which results from the removal of the pituitary gland.

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Establishing Standards for Studying Renal Function in Mice through Measurements of Body Size-Adjusted Creatinine and Urea Levels

BioMed Research International ◽

10.1155/2014/872827 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

Wellington Francisco Rodrigues ◽

Camila Botelho Miguel ◽

Marcelo Henrique Napimoga ◽

Carlo Jose Freire Oliveira ◽

Javier Emilio Lazo-Chica

Keyword(s):

Renal Function ◽

Body Weight ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Measurement Techniques ◽

The Body ◽

Urea Concentration ◽

Time Points ◽

Average Factor

Strategies for obtaining reliable results are increasingly implemented in order to reduce errors in the analysis of human and veterinary samples; however, further data are required for murine samples. Here, we determined an average factor from the murine body surface area for the calculation of biochemical renal parameters, assessed the effects of storage and freeze-thawing of C57BL/6 mouse samples on plasmatic and urinary urea, and evaluated the effects of using two different urea-measurement techniques. After obtaining 24 h urine samples, blood was collected, and body weight and length were established. The samples were evaluated after collection or stored at −20°C and −70°C. At different time points (0, 4, and 90 days), these samples were thawed, the creatinine and/or urea concentrations were analyzed, and samples were restored at these temperatures for further measurements. We show that creatinine clearance measurements should be adjusted according to the body surface area, which was calculated based on the weight and length of the animal. Repeated freeze-thawing cycles negatively affected the urea concentration; the urea concentration was more reproducible when using the modified Berthelot reaction rather than the ultraviolet method. Our findings will facilitate standardization and optimization of methodology as well as understanding of renal and other biochemical data obtained from mice.

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