Pathogenesis and Prevention of the Dawn Phenomenon in Diabetic Patients Treated with CSII

Diabetes ◽  
1986 ◽  
Vol 35 (1) ◽  
pp. 78-82 ◽  
Author(s):  
V. A. Koivisto ◽  
H. Yki-Jarvinen ◽  
E. Helve ◽  
S.-L. Karonen ◽  
R. Pelkonen
Keyword(s):  
Diabetic Patients ◽  
Dawn Phenomenon

scholarly journals Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver

Endocrinology ◽  
2015 ◽  
Vol 157 (2) ◽  
pp. 463-469 ◽  
Author(s):  
Hitoshi Ando ◽  
Kentaro Ushijima ◽  
Shigeki Shimba ◽  
Akio Fujimura
Keyword(s):  
Blood Glucose ◽  
Circadian Clock ◽  
Mrna Expression ◽  
Hepatic Glucose Production ◽  
Critical Role ◽  
Fasting Blood Glucose ◽  
Glucose Production ◽  
Diabetic Patients ◽  
Dark Phase ◽  
Dawn Phenomenon

Abstract Fasting blood glucose (FBG) and hepatic glucose production are regulated according to a circadian rhythm. An early morning increase in FBG levels, which is pronounced among diabetic patients, is known as the dawn phenomenon. Although the intracellular circadian clock generates various molecular rhythms, whether the hepatic clock is involved in FBG rhythm remains unclear. To address this issue, we investigated the effects of phase shift and disruption of the hepatic clock on the FBG rhythm. In both C57BL/6J and diabetic ob/ob mice, FBG exhibited significant daily rhythms with a peak at the beginning of the dark phase. Light-phase restricted feeding altered the phase of FBG rhythm mildly in C57BL/6J mice and greatly in ob/ob mice, in concert with the phase shifts of mRNA expression rhythms of the clock and glucose production–related genes in the liver. Moreover, the rhythmicity of FBG and Glut2 expression was not detected in liver-specific Bmal1-deficient mice. Furthermore, treatment with octreotide suppressed the plasma growth hormone concentration but did not affect the hepatic mRNA expression of the clock genes or the rise in FBG during the latter half of the resting phase in C57BL/6J mice. These results suggest that the hepatic circadian clock plays a critical role in regulating the daily FBG rhythm, including the dawn phenomenon.

Non-insulin-dependent diabetic patients (NIDDMs) do not demonstrate the dawn phenomenon at presentation

1988 ◽  
Vol 5 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Jameal A. Atiea ◽  
Jiten P. Vora ◽  
David R. Owens ◽  
Steve Luzio ◽  
G.F. Read ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Dawn Phenomenon ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

The Dawn Phenomenon in non-Insulin Dependent Diabetic Patients

1985 ◽  
Vol 69 (s12) ◽  
pp. 70P-70P
Author(s):  
J.A. Atiea ◽  
R.E.J Ryder ◽  
J. Vora ◽  
D.R. Owens ◽  
M.A. Mir ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Dawn Phenomenon ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Pathogenesis and prevention of the dawn phenomenon in diabetic patients treated with CSII

Diabetes ◽  
1986 ◽  
Vol 35 (1) ◽  
pp. 78-82 ◽  
Author(s):  
V. A. Koivisto ◽  
H. Yki-Jarvinen ◽  
E. Helve ◽  
S. L. Karonen ◽  
R. Pelkonen
Keyword(s):  
Diabetic Patients ◽  
Dawn Phenomenon

Dawn Phenomenon: Its Frequency in Non-Insulin-Dependent Diabetic Patients on Conventional Therapy

Diabetes Care ◽  
1987 ◽  
Vol 10 (4) ◽  
pp. 461-465 ◽  
Author(s):  
J. A. Atiea ◽  
R. R. J. Ryder ◽  
J. Vora ◽  
D. R. Owens ◽  
S. D. Luzio ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Diabetic Patients ◽  
Dawn Phenomenon ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Effects of Exercise on Blood Glucose and Glycemic Variability in Type 2 Diabetic Patients with Dawn Phenomenon

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Xin Zheng ◽  
Yanyan Qi ◽  
Lina Bi ◽  
Wenli Shi ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Aerobic Exercise ◽  
Glycemic Variability ◽  
Hypoglycemic Agents ◽  
Moderate Intensity ◽  
Diabetic Patients ◽  
Glucose Excursion ◽  
Dawn Phenomenon ◽  
Type 2 Diabetic

Background. The dawn phenomenon (DP) is the primary cause of difficulty in blood glucose management in type 2 diabetic (T2D) patients, and the use of oral hypoglycemic agents has shown weak efficacy in controlling DP. Thus, this study is aimed at investigating the effect of moderate-intensity aerobic exercise before breakfast on the blood glucose level and glycemic variability in T2D patients with DP. Methods. A total of 20 T2D patients with DP confirmed via continuous glucose monitoring (CGM) participated in the current study. After collecting baseline measurements by CGM as a control, CGM was reinstalled and 30 minutes of moderate-intensity aerobic exercise was performed prior to breakfast. Dawn blood glucose increase, blood glucose levels, and glycemic variability were measured before and after exercise. Results. Dawn blood glucose increase (ΔGlu, 1.25±0.84vs.2.15±1.07, P=0.005), highest blood glucose value before breakfast (Gmax, 8.01±1.16vs. 8.78±1.09, P=0.005), and mean blood glucose (MBG, 7.80±0.97vs. 8.37±0.95, P=0.001) were all lower, and time in range (TIR, 90.75±12.27vs. 83.5±15.41, P=0.015) was higher after exercise than before exercise. Among the glycemic variability indicators, blood glucose standard deviation (SD, 1.1±0.5vs. 1.48±0.63, P=0.001), coefficient of variation (CV, 14.14±5.94vs.17.69±7.46, P=0.006), mean amplitude of glucose excursion (MAGE, 2.71±1.52vs.3.73±1.98, P=0.006), and largest amplitude of glucose excursion (LAGE, 4.97±2.07vs.6.41±2.36, P=0.002) were all decreased following exercise. Conclusions. Acute moderate-intensity aerobic exercise before breakfast reduced the morning rise of blood glucose in T2D patients, partially counteracting DP. Furthermore, exercise significantly reduced blood glucose fluctuations and improved blood glucose control throughout the day. We recommend that T2D patients with DP take moderate-intensity aerobic exercise before breakfast to improve DP and glycemic control.

Studies on the pathogenesis of the dawn phenomenon in insulin-dependent diabetic patients

Metabolism ◽  
1984 ◽  
Vol 33 (5) ◽  
pp. 458-464 ◽  
Author(s):  
Wolfgang Kerner ◽  
Ignacio Navascués ◽  
Angel A. Torres ◽  
Ernst F. Pfeiffer
Keyword(s):  
Diabetic Patients ◽  
Dawn Phenomenon ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

A Comparison Between Sterological Point Counting and Digitizing Tablets

1985 ◽  
Vol 43 ◽  
pp. 666-667
Author(s):  
John M. Basgen ◽  
Eileen N. Ellis ◽  
S. Michael Mauer ◽  
Michael W. Steffes
Keyword(s):  
Electron Microscopy ◽  
Kidney Tissue ◽  
Volume Density ◽  
Diabetic Patients ◽  
Normal Kidney ◽  
Point Counting ◽  
Normal Kidney Tissue ◽  
Biopsy Specimens ◽  
Mitochondrial Volume ◽  
Kidney Lesions

To determine the efficiency of methods of quantitation of the volume density of components within kidney biopsies, techniques involving a semi-automatic digitizing tablet and stereological point counting were compared.Volume density (Vv) is a parameter reflecting the volume of a component to the volume that contains the component, e.g., the fraction of cell volume that is made up of mitochondrial volume. The units of Vv are μm3 /μm3.Kidney biopsies from 15 patients were used. Five were donor biopsies performed at the time of kidney transplantation (patients 1-5, TABLE 1) and were considered normal kidney tissue. The remaining biopsies were obtained from diabetic patients with a spectrum of diabetic kidney lesions. The biopsy specimens were fixed and embedded according to routine electron microscogy protocols. Three glomeruli from each patient were selected randomly for electron microscopy. An average of 12 unbiased and systematic micrographs were obtained from each glomerulus and printed at a final magnification of x18,000.

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