Insulin adsorbance to polyvinylchloride surfaces with implications for constant-infusion therapy

Diabetes ◽  
1976 ◽  
Vol 25 (1) ◽  
pp. 72-74 ◽  
Author(s):  
L. Peterson ◽  
J. Caldwell ◽  
J. Hoffman
Neurosurgery ◽  
1991 ◽  
Vol 29 (5) ◽  
pp. 739-742 ◽  
Author(s):  
Joel W. Winer ◽  
Robert H. Rosenwasser ◽  
Robert H. Rosenwasser

Abstract Controversy exists regarding the optimal means for monitoring the patient receiving pentobarbital therapy during medical coma. Serum pentobarbital levels have been used traditionally to gauge cerebral penetration and efficacy of the drug. These peripheral levels have been assumed to reflect pentobarbital concentrations in the cerebrospinal fluid (CSF) and, therefore, the physiological effect on the central nervous system. To determine the relative accuracy of serum versus CSF pento-barbital levels, continuous electroencephalographic (EEG) monitoring in 10 consecutive patients was studied prospectively. Each patient received pentobarbital therapy for cerebral protection in the face of a traumatic injury. Simultaneous serum and CSF pentobarbital levels were obtained 1) before and after the initial barbiturate bolus, 2) every 12 hours during constant infusion therapy, and 3) before and after subsequent boluses necessary because of elevated intracranial pressure (ICP) (ICP > 15 mm Hg) or loss of burst suppression by continuous EEG monitoring (defined as greater than five bursts per minute). ICP and relevant clinical events were recorded hourly. Serum and CSF levels ranged from 33 to 74 mg/L and 4 to 54 mg/L, respectively. There was poor correlation between serum and CSF pentobarbital levels at any given time, although patients remained in burst suppression 73% of the time during their therapy. The EEG monitoring not only provided dynamic physiological monitoring, but it also permitted the lowest pentobarbital dose to maintain burst suppression for a specific patient's metabolism, reducing the likelihood of toxicity. In conclusion, CSF pentobarbital levels are of no greater accuracy than serum pentobarbital levels in predicting physiological effect. Constant EEG monitoring remains the best modality by showing the presence of burst suppression moment-to-moment and thus establishing the minimal necessary dose.


Diabetes ◽  
1976 ◽  
Vol 25 (1) ◽  
pp. 72-74 ◽  
Author(s):  
L. Peterson ◽  
J. Caldwell ◽  
J. Hoffman

1969 ◽  
Vol 33 (4) ◽  
pp. 581-584
Author(s):  
H Sasaki ◽  
T Wakutani ◽  
S Oda ◽  
Y Yamazaki

2006 ◽  
Vol 95 (3) ◽  
pp. 312-317 ◽  
Author(s):  
Anders Erikson ◽  
Håkan Forsberg ◽  
Magnus Nilsson ◽  
Marianne Åström ◽  
Jan-Eric Månsson

2018 ◽  
Vol 23 (02) ◽  
pp. 60-61
Author(s):  
Helena Thiem

Schmier J et al. Costs of Providing Infusion Therapy for Rheumatoid Arthritis in a Hospitalbased Infusion Center Setting. Clin Ther 2017; 39: 1600–1617 Für betroffene Patienten hat die rheumatoide Arthritis lebenslang schwerwiegende Folgen. Eine angemessene Therapie ist deshalb unabdingbar. In den Vereinigten Staaten wird eine Vielzahl dieser Patienten stationär anhand einer Infusionstherapie behandelt. Die Autoren ermitteln für vier gängige Präparate, mit welchen Kosten diese Behandlung für die Krankenhäuser verbunden ist.


1987 ◽  
Vol 58 (04) ◽  
pp. 1068-1072 ◽  
Author(s):  
P Toulon ◽  
J F Vitoux ◽  
C Leroy ◽  
T Lecomte ◽  
M Roncato ◽  
...  

SummaryWe compared in six patients successively treated with an unfractionated heparin (UFH) and a low molecular weight heparin (LMWH) the variations in plasma anti-Xa activity, measured in a chromogenic assay, during a 36 h constant infusion. The values varied in a wider range during UHF infusion, but remained in the therapeutic range except once in one patient. No circadian rhythm could be demonstrated in our six patients. LMWH infusion yielded very constant anti-Xa circulating activities. In both cases, there were no significant modifications of three proteins with high heparin affinity (antithrombin III, heparin cofactor II, histidine-rich glycoprotein).Our results suggest that the circadian rhythm of the biological activities previously observed in patients treated with constant heparin infusion using clotting method is due to other factors than heparin itself.


2020 ◽  
Vol 99 (5) ◽  
pp. 493-497
Author(s):  
M. M. Aslanova ◽  
T. V. Gololobova ◽  
K. Yu. Kuznetsova ◽  
Tamari R. Maniya ◽  
D. V. Rakitina ◽  
...  

Introduction. The purpose of our work was to justify the need to improve the legislative, regulatory and methodological framework and preventative measures in relation to the spread of parasitic infections in the provision of medical care. There is a wide range of pathogens of parasitic infestations that are transmitted to humans through various medical manipulations and interventions carried out in various medical institutions. Contaminated care items and furnishings, medical instruments and equipment, solutions for infusion therapy, medical personnel’s clothing and hands, reusable medical products, drinking water, bedding, suture and dressing materials can serve as a major factor in the spread of parasitic infections in the provision of medical care. Purpose of research is the study of the structure and SMP of parasitic origin, circulating on the objects of the production environment in multi-profile medical and preventive institutions of stationary type in order to prevent the occurrence of their spread within medical institutions. Material and methods. The material for the study was flushes taken from the production environment in 3 multi-profile treatment and prevention institutions of inpatient type: a multi-specialty hospital, a maternity hospital and a hospital specializing in the treatment of patients with intestinal diseases for the eggs of worms and cysts of pathogenic protozoa. Results. During the 2-year monitoring of medical preventive institutions, a landscape of parasitic contamination was found to be obtained from the flushes taken from the production environment objects in the premises surveyed as part of the research work. Discussions. In the course of research, the risk of developing ISMP of parasitic origin was found to be determined by the degree of epidemiological safety of the hospital environment, the number and invasiveness of treatment and diagnostic manipulations and various medical technologies. Conclusion. It is necessary to conduct an expert assessment of regulatory and methodological documents in the field of epidemiological surveillance and sanitary and hygienic measures for the prevention of medical aid related infections of parasitic origin, to optimize the regulatory and methodological base, to develop a number of preventive measures aimed at stopping the spread of parasitic infections in the medical network.


2017 ◽  
Vol 1 (2) ◽  
pp. 73-76
Author(s):  
Ilgın YILDIRIM ŞİMŞİR ◽  
Vildan ÖZKAN DERVİŞ ◽  
Şevki ÇETİNKALP

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