Compensation in pancreatic beta-cell function in subjects with glucokinase mutations

Diabetes ◽  
1994 ◽  
Vol 43 (5) ◽  
pp. 718-723 ◽  
Author(s):  
J. Sturis ◽  
I. J. Kurland ◽  
M. M. Byrne ◽  
E. Mosekilde ◽  
P. Froguel ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Pancreatic Beta Cell Function ◽  
Glucokinase Mutations

Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM

Diabetes ◽  
1996 ◽  
Vol 45 (11) ◽  
pp. 1572-1579 ◽  
Author(s):  
K. Berkowitz ◽  
R. Peters ◽  
S. L. Kjos ◽  
J. Goico ◽  
A. Marroquin ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
High Risk ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Pancreatic Beta Cell Function

scholarly journals Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Haoyong Yu ◽  
Ruixia Li ◽  
Lei Zhang ◽  
Haibing Chen ◽  
Yuqian Bao ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Beta Cell ◽  
Total Cholesterol ◽  
Beta Cell Function ◽  
Cell Function ◽  
Total Cholesterol Level ◽  
Pancreatic Beta Cell ◽  
Elevated Serum ◽  
Diabetic Patients ◽  
Pancreatic Beta Cell Function

CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.

scholarly journals Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115433 ◽  
Author(s):  
Donna L. Nile ◽  
Audrey E. Brown ◽  
Meutia A. Kumaheri ◽  
Helen R. Blair ◽  
Alison Heggie ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Age Related ◽  
Mitochondrial Dna Depletion ◽  
Pancreatic Beta Cell Function ◽  
The Impact

scholarly journals OR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Shivraj Grewal ◽  
Andin Fosam ◽  
Liam Chalk ◽  
Arjun Deven ◽  
Mari Suzuki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Beta Cell ◽  
Primary Aldosteronism ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Pancreatic Beta Cell Function

scholarly journals Circulating C-Peptide: Measurement and Clinical Application

1981 ◽  
Vol 18 (3) ◽  
pp. 125-130 ◽  
Author(s):  
J Peter Ashby ◽  
Brian M Frier
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Plasma Insulin ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Plasma Insulin Concentration ◽  
C Peptide ◽  
Clinical Disorders ◽  
Pancreatic Beta Cell Function ◽  
Secretory Capacity

Pancreatic beta-cell function is usually assessed by the measurement of plasma insulin concentration in various clinical situations. However, the advent of an assay for the measurement of connecting-peptide (C-peptide) concentration in plasma has provided a further method for the assessment of the secretory capacity of the pancreatic beta cell in clinical disorders, particularly in the investigation of hypoglycaemia. The metabolism and immunoassay methodology of C-peptide are reviewed, and its application in clinical practice is outlined.

Prenatal androgen excess impairs beta cell function by decreased Sirtuin3 expression

2021 ◽  
Author(s):  
Yu Zhou ◽  
Min Gong ◽  
Yingfei Lu ◽  
Jianquan Chen ◽  
Rong Ju
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Female Offspring ◽  
Sirtuin 3 ◽  
Prenatal Testosterone ◽  
Pancreatic Beta Cell Function ◽  
Prenatal Androgen

Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially on pancreatic beta cell function, is rarely investigated. Our current study mainly focused on the effects of prenatal testosterone exposure on glucose metabolism and pancreatic beta cell function in aged female offspring. By using maternal mice and their female offspring as animal models, we found that prenatal androgen treatment induced obesity and glucose intolerance in aged offspring. These influences were accompanied by decreased fasting serum insulin concentration, elevated serum triglyceride and testosterone concentrations. Glucose stimulated insulin secretion in pancreatic beta cells of aged female offspring was also affected by prenatal testosterone exposure. We further confirmed that increased serum testosterone contributed to down regulation of Sirtuin 3 expression, activated oxidative stress and impaired pancreatic beta cell function in aged female offspring. Moreover, over-expression of Sirtuin 3 in islets isolated from female offspring treated with prenatal testosterone normalized the oxidative stress level, restored cyclic adenosine monophosphate and adenosine triphosphate generation, which finally improved glucose stimulated insulin secretion in beta cells. Taken together, these results demonstrated that prenatal testosterone exposure caused metabolic disturbance in aged female offspring via suppression of Sirtuin 3 expression and activation of oxidative stress in pancreatic beta cells.

Role of the Interaction Between Nck1 and PERK in Pancreatic Beta Cell Function and Survival

2021 ◽  
Vol 45 (7) ◽  
pp. S34
Author(s):  
Laure Monteillet ◽  
Émilie Courty ◽  
Nathalie Jouvet ◽  
Marco Gasparrini ◽  
Cindy Baldwin ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Pancreatic Beta Cell Function
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