Vitality, perceived social support and disease activity determine the performance of social roles in recently diagnosed multiple sclerosis: A longitudinal analysis

Abstract Background: Multiple sclerosis (MS) is the most common neurological disease with disabling consequences. Social support is an important aspect of performance among patients and attention to perceived social support as a factor influencing health promotion is essential. Therefore, this study was performed with the aim to determine the relationship between spiritual well-being and perceived social support in patients with MS.Methods: This cross-sectional and correlational study was conducted on 120 patients with MS. The participants were over 18 years of age and referred to the MS Clinic of Kashani Hospital, Isfahan‎, Iran. The subjects were selected using convenience sampling. Data were collected using questionnaires and analyzed using descriptive and inferential statistics in SPSS software. P-values of less than 0.05 were considered significant.Results: The mean (SD) disease duration and age of participants were 8.1 (5.9) and 33.67 (8.7) years, respectively. Moreover, 75.9% of the participants were women and 76.1% were married. The mean score of spiritual well-being was 87.08. The mean score of perceived social support was 61.52 (14.9). Pearson correlation test indicated a direct relationship between spiritual well-being and the total score of perceived social support (r = 0.415, P < 0.001) and the emotional (r = 0.328, P = 0.004) and informational (r = 0.311, P = 0.006) dimensions, but not the instrumental dimension (r = 0.197, P = 0.081). Multiple linear regression analysis showed a significant correlation between spiritual health and social support in the emotional dimension (P < 0.05)Conclusion: This study confirmed the relation between perceived social support and spiritual well-being of people with MS. Thus, it is necessary that perceived social support, as a strong predictor of spiritual health status, is considered in the designing of health promotion interventions for patients with MS.

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Translation and cultural adaptation of the Multidimensional Scale of Perceived Social Support for Greece

Health Psychology Research ◽

10.4081/hpr.2015.1061 ◽

2015 ◽

Vol 3 (1) ◽

Cited By ~ 2

Author(s):

Paraskevi Theofilou

Keyword(s):

Multiple Sclerosis ◽

Social Support ◽

Cultural Adaptation ◽

Perceived Social Support ◽

Greek Version ◽

Back Translation ◽

Translation And Cultural Adaptation

Recently, there is a surge of interest in the use of the Multidimensional Scale of Perceived Social Support (MSPSS) to measure perceived social support across cultures. The objective of this study was to translate and make the cultural adaptation of the Greek version of the MSPSS. The study counted with a sample of 10 patients diagnosed with multiple sclerosis. The process involved the following steps of translation back translation and semantic evaluation. The former revealed good acceptance of the translated version of the instrument, which participants considered having items of easy understanding. After completing the process of validation in the country, the instrument will become available to Greek researchers to measure social support, as well as to compare results from Greece to that of other cultures in which the instrument has already been validated.

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Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2018.09.039 ◽

2019 ◽

Vol 27 ◽

pp. 46-51 ◽

Cited By ~ 13

Author(s):

Audrey Henry ◽

Ayman Tourbah ◽

Gauthier Camus ◽

Romain Deschamps ◽

Laurence Mailhan ◽

...

Keyword(s):

Multiple Sclerosis ◽

Social Support ◽

Perceived Social Support ◽

Anxiety And Depression ◽

Mediating Effects

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Longitudinal Analysis of Depressive Symptoms, Perceived Social Support, and Alcohol Use among HIV-Infected Men Who Inject Drugs in Northern Vietnam

Substance Use & Misuse ◽

10.1080/10826084.2020.1732422 ◽

2020 ◽

Vol 55 (8) ◽

pp. 1237-1245 ◽

Cited By ~ 2

Author(s):

Rebecca B. Hershow ◽

Nisha C. Gottfredson ◽

Tran Viet Ha ◽

Viet Anh Chu ◽

Kathryn E. Lancaster ◽

...

Keyword(s):

Social Support ◽

Depressive Symptoms ◽

Alcohol Use ◽

Longitudinal Analysis ◽

Perceived Social Support ◽

Northern Vietnam

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Factors associated with perceived social support of patients with multiple sclerosis

Current Journal of Neurology ◽

10.18502/cjn.v20i2.6741 ◽

2021 ◽

Author(s):

Aikaterini Papa ◽

Ioannis Koutelekos ◽

Spyridoula Stefanidou ◽

Chrysa Chrysovitsanou ◽

Maria Polikandrioti

Keyword(s):

Multiple Sclerosis ◽

Social Support ◽

Family Environment ◽

Perceived Social Support ◽

Significant Others ◽

Cross Sectional Study ◽

Daily Activities ◽

Cross Sectional ◽

Factors Associated ◽

The Central Nervous System

Background: Multiple sclerosis (MS) is an inflammatory chronic disease of the central nervous system (CNS) which is related with unpredictable course and increasing disability. Social support as an available interpersonal resource may help patients with MS. The purpose of the present study was to evaluate perceived social support in patients with MS as well as the associated factors. Methods: The sample of this cross-sectional study included 200 patients with MS. Data collection was performed by the completion of the Multidimensional Scale of Perceived Social Support (MSPSS) and a questionnaire which included patients' characteristics. Results: Patients reported to perceive high support from significant others and their family (median: 24.0 and 23.5, respectively) and less from their friends (median: 20). Moreover, a statistically significant association was found between social support from significant others and marital status (P = 0.010), modification of daily activities (P = 0.018), difficulties with social and family environment (P ≤ 0.001 and P ≤ 0.001, respectively), frequent urination (P = 0.015), and whether they easily forgot (P = 0.049), characterized themselves as anxious (P = 0.049), and believed in God (P = 0.002). Also, a statistically significant association was fond between social support from family and relation with health professionals (P = 0.041), difficulties with social and family environment (P = 0.003 and P ≤ 0.001, respectively), and whether they considered themselves as anxious (P = 0.050), and they believed in God (P ≤ 0.001). Furthermore, a statistically significant association was found between support from friends and modification of daily activities (P = 0.010), help in daily activities (P = 0.016), need for movement assistance (P = 0.001), difficulties with social and family environment (P ≤ 0.001 and P = 0.005, respectively), and whether they considered themselves anxious (P = 0.046). Conclusion: Factors associated with perceived social support should be evaluated when planning holistic care to patients with MS.

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Longitudinal analysis of serum neurofilament light chain: A potential therapeutic monitoring biomarker for multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458519840757 ◽

2019 ◽

Vol 26 (6) ◽

pp. 659-667 ◽

Cited By ~ 4

Author(s):

Jae-Won Hyun ◽

Yeseul Kim ◽

Gayoung Kim ◽

Su-Hyun Kim ◽

Ho Jin Kim

Keyword(s):

Multiple Sclerosis ◽

Disease Activity ◽

Single Molecule ◽

Light Chain ◽

Longitudinal Analysis ◽

Therapeutic Monitoring ◽

Multiple Time ◽

Neurofilament Light Chain ◽

Neurofilament Light ◽

Potential Biomarker

Objectives: Serum neurofilament light chain (sNfL) has been proposed a potential biomarker in multiple sclerosis (MS) based on mainly cross-sectional observations in Western population. To clarify clinical implication of sNfL, we longitudinally analysed sNfL levels at multiple time points in Korean MS patients undergoing alemtuzumab therapy. Methods: Between 2016 and 2018, 144 sera from 17 MS patients treated with alemtuzumab at National Cancer Centre and 35 sera from 35 age- and gender-matched healthy controls (HCs) were collected for a longitudinal study with a mean 21-month follow-up. The sera were measured for sNfL levels using single molecule array. Patients were classified into two groups: evidence of disease activity (EDA) or no evidence of disease activity (NEDA). Results: During alemtuzumab therapy, sNfL levels in EDA patients were significantly higher than those in NEDA patients and HCs ( p < 0.001). In longitudinal analysis, the sNfL levels were consistently low in NEDA patients, while it consistently increased in radiologically and/or clinically active status in EDA patients. All sNfL levels in radiologically and/or clinically active status samples were higher than those in inactive status samples. Conclusion: These results suggest that sNfL is a promising monitoring biomarker for personalized therapeutics in MS patients.

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