scholarly journals The Host Inflammatory Response Promotes Liver Metastasis by Increasing Tumor Cell Arrest and Extravasation

2007 ◽  
Vol 170 (5) ◽  
pp. 1781-1792 ◽  
Author(s):  
Patrick Auguste ◽  
Lucia Fallavollita ◽  
Ni Wang ◽  
Julia Burnier ◽  
Andreas Bikfalvi ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Inflammatory Response ◽  
Tumor Cell ◽  
Cell Arrest ◽  
Host Inflammatory Response

scholarly journals AB0713 PERIODONTAL DISEASES AND ITS ASSOCIATION WITH ANKYLOSING SPONDYLITIS/SPA: A SYSTEMATIC REVIEW

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1652.1-1652
Author(s):  
A. Pandey ◽  
V. Ravindran ◽  
M. Pandey ◽  
R. Rajak ◽  
V. Pandey
Keyword(s):  
Systematic Review ◽  
Ankylosing Spondylitis ◽  
Connective Tissue ◽  
Inflammatory Response ◽  
Periodontal Disease ◽  
Close Association ◽  
Case Control ◽  
Clinical Attachment Loss ◽  
Tnf Α ◽  
Host Inflammatory Response

Background:A close association between periodontal disease and Ankylosing spondylitis (AS) has long been specualted. Both diseases are characterized by dysregulation of the host inflammatory response, leading to further destruction of soft and hard connective tissue with there being evidence of increased levels of TNF-α and various interleukins in both patients of AS and periodontitis.Objectives:The aim of this systematic review was to appraise the available literature exploring the relationship between AS and periodontal disease.Methods:We searched Medline & Embase databases (from their inception till October 2019) using appropriate combinations of following search items with limits ‘(English, Human)’; Ankylosing spondylitis, spondyloarthritis, spondyloarthropathies, spondyloarthritides, spinal disease, musculoskeletal disease, Rheumatic disease AND periodontitis, periodontal disease, periodontoses, parodontoses, chronic periodontitis, gum disease, gingivitis, oral health, dental health, plaque index, bleeding on probing, probing pocket depth, clinical attachment loss. This search was supplemented by the manual search of bibliographies of articles selected and conferences proceedings of EULAR. Only be reviews, observational study of cross-sectional, cohort or case control type on adult patients with AS were selected. Data was extracted from a predesigned proforma. A close association between periodontal disease and Ankylosing spondylitis (AS) has long been specualted. Both diseases are characterized by dysregulation of the host inflammatory response, leading to further destruction of soft and hard connective tissue with there being evidence of increased levels of TNF-α and various interleukins in both patients of AS and periodontitis.Results:A total number of 984 articles were identified and 12 were selcted for detailed appraisal (Figure 1, PRISMA flow chart). They were all case control studies. The prevalence of periodontitis ranged from 38% to 88% in patients with AS whereas in the control group from 26% to 71 % in controls. Out of 12 studies, two showed significant changes in Plaque Index (PI), two studies showed altered Pocket Probing Depth (PPD), three showed significant increased in Clinical Attachment Loss (CAL) and increased Bleeding On Probing (BOP) was seen in 2 studies. In 7 studies, periodontitis was seen in a significant number of patients with AS (P<0.05). All studies reported that the prevalence of periodontal disease in AS patients was higher as compared to non-AS patients.Conclusion:Our systematic review found an association between AS and periodontal disease. Patients with AS show higher prevalence of periodontitis and a poor oral hygiene as compared to healthy controls. At practice level, this systematic review underscores the need for a collaboration between dentists and rheumatologist.Disclosure of Interests:None declared

PPE11 of Mycobacterium tuberculosis can alter host inflammatory response and trigger cell death

2019 ◽  
Vol 126 ◽  
pp. 45-55 ◽  
Author(s):  
Xuan Peng ◽  
Tao Luo ◽  
Xiaoqian Zhai ◽  
Chunxi Zhang ◽  
Jing Suo ◽  
...  
Keyword(s):  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Inflammatory Response ◽  
Trigger Cell Death ◽  
Host Inflammatory Response

scholarly journals Coating Polyurethane with Palmitoleic Acid and Bovine Serum Albumin to Prevent the Host Response to Foreign Materials

2020 ◽  
Vol 16 (4) ◽  
pp. 5-13 ◽  
Author(s):  
Sheherbano Hussain ◽  
Zoha Babar ◽  
Jimmy Hadid ◽  
Jacqueline McLaughlin
Keyword(s):  
Bovine Serum Albumin ◽  
Inflammatory Response ◽  
Serum Albumin ◽  
Medical Devices ◽  
Bovine Serum ◽  
Host Response ◽  
Palmitoleic Acid ◽  
Implanted Medical Devices ◽  
Foreign Materials ◽  
Host Inflammatory Response

Macrophages are cells of the immune system that play a pivotal role in the host inflammatory response by attacking and engulfing any foreign molecule not seen as ‘self.’ They also help regulate the host response by releasing a variety of cytokines and growth factors that act as signals to other cells to amplify the host response. However, the host response causes degradation of implanted medical devices composed of polyurethane as well as other synthetic materials which it does not identify as self. Research was undertaken to investigate the potential of coating polyurethane with the self-like molecules palmitoleic acid and albumin to reduce or prevent the body’s host response from damaging implanted medical devices. Using an in vitro THP-1 bioassay, polyurethane films coated with palmitoleic acid and bovine serum albumin showed a reduction in macrophage adherence. The individually coated palmitoleic acid and bovine serum albumin films significantly reduced the number of cells attached to the films with increasing concentration while the films coated with the conjugate of both showed no statistical difference. This suggests the potential role of self-like molecules in reducing the inflammatory response to foreign materials. KEYWORDS: Macrophages; host inflammatory response; THP-1; prosthetics; palmitoleic acid; bovine serum albumin; cytokines; immune system

scholarly journals Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

2010 ◽  
Vol 9 (1) ◽  
Author(s):  
Mario Dell'Agli ◽  
Germana V Galli ◽  
Michela Bulgari ◽  
Nicoletta Basilico ◽  
Sergio Romeo ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Punica Granatum ◽  
Host Inflammatory Response ◽  
Fruit Rind

scholarly journals Peri-Implant Diseases and Host Inflammatory Response Involving Mast Cells: A Review

2011 ◽  
Vol 24 (3) ◽  
pp. 557-566 ◽  
Author(s):  
A. Zizzi ◽  
S.D. Aspriello ◽  
C. Rubini ◽  
G. Goteri
Keyword(s):  
Mast Cells ◽  
Inflammatory Response ◽  
Host Inflammatory Response

Host Inflammatory Response to Infection

2014 ◽  
pp. 471-480 ◽  
Author(s):  
Jide Wang ◽  
Thomas G. Blanchard ◽  
Peter B. Ernst
Keyword(s):  
Inflammatory Response ◽  
Host Inflammatory Response
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