Normal saline versus balanced-salt solution as intravenous fluid therapy during neurosurgery: effects on acid-base balance and electrolytes

2017 ◽  
Vol 61 (3) ◽  
Author(s):  
Mohamed Hafizah ◽  
Chian Y. LIU ◽  
Joanna S. Ooi
Keyword(s):  
Fluid Therapy ◽  
Salt Solution ◽  
Normal Saline ◽  
Intravenous Fluid ◽  
Acid Base Balance ◽  
Acid Base ◽  
Intravenous Fluid Therapy ◽  
Base Balance

scholarly journals Comparative Trial of Continuous Flow Enteral and Intravenous Fluid Therapy in Horses

2021 ◽  
Vol 8 ◽  
Author(s):  
Domingos C. R. Dias ◽  
José D. Ribeiro Filho ◽  
Rinaldo B. Viana ◽  
Thereza C. C. Bittencourt ◽  
Fernanda T. D. R. Dantas ◽  
...  
Keyword(s):  
Fluid Therapy ◽  
Continuous Flow ◽  
Urine Volume ◽  
Comparative Trial ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Intravenous Fluid ◽  
Acid Base Balance ◽  
Acid Base ◽  
Intravenous Fluid Therapy

Continuous flow enteral fluid therapy with isotonic and hypotonic enteral electrolyte solutions are as safe and effective as intravenous fluid therapy. The aim of this study was to carry out a comparative assessment between continuous flow enteral and intravenous (IV) fluid therapy in adult experimentally dehydrated horses. Six experimentally dehydrated adult mares were used in a study carried out in a 6 × 3 crossover design, which each animal received three different treatments (isotonic enteral fluid therapy—EsISO, hypotonic enteral fluid therapy—EsHYPO and intravenous fluid therapy with Lactate Ringer Solution—LR IV, all in continuous flow). Solutions were administered at a rate of 15 mL−1.kg−1.h−1 for 8 h, after 36 h of water and food deprivation. Serum and urinary biochemical assessment; urinary volume, pH and specific gravity; and blood gas analysis were measured at −36, 0, 2, 4, 6, and 8 h. The dehydration period (DP) caused discrete hydroelectrolytic and acid base imbalances. The EsISO, EsHYPO and LR IV increased blood volume. Enteral solutions restored the imbalances yielded by the DP and all treatments increased urine volume. Also, the EsHYPO and LR IV showed no effects in acid base balance, while EsISO showed slightly acidifying effect. The present study certifies the efficacy and safety of isotonic and hypotonic continuous flow enteral fluid therapy in comparison to IV fluid therapy in dehydrated horses.

scholarly journals Choice of Drug for Intravenous Fluid Therapy in the Early Postoperative Period in Children

2020 ◽  
Vol 16 (5) ◽  
pp. 30-36
Author(s):  
V. V. Lazarev ◽  
Zh. D. Sulaimanova ◽  
L. E. Tsypin ◽  
G. P. Brusov ◽  
T. V. Eryasheva
Keyword(s):  
Phase Angle ◽  
Fluid Therapy ◽  
Postoperative Period ◽  
Potassium Level ◽  
Early Postoperative Period ◽  
Nacl Solution ◽  
Acid Base Balance ◽  
Acid Base ◽  
Intravenous Fluid Therapy ◽  
Base Balance

The choice of drug for initial fluid therapy in the early postoperative period is important in terms of clinical efficacy and cost-effectiveness of the combination treatment.The aim of the study was to compare the effects of a succinate-containing solution and 0.9% NaCl solution when used as a drug of initial intravenous fluid therapy in early postoperative period in children.Materials and methods. A prospective randomized trial was conducted with participation of 43 patients having ASA II—III score after elective surgical interventions with a duration of 1-3 hours. In Group I («N») (n=23) the patients received continuous infusion of 0.9% NaCl solution in the early postoperative period (within 3 hours after the operation), in Group 2 («R») (n=20) continuous infusion of a succinate-containing solution was administered in 2.3 (1.6; 2.8) mode. The inter- and intragroup differences during the study were estimated by the changes of water-electrolyte and acid-base balance, basal metabolism, and phase angle (estimated integral index of cellular membranes condition) values. The data were recorded during the 5 stages of the study: 1 — immediately upon ICU admission (baseline), 2 — 60 minutes, 3 — 90 minutes, 4 — 120 minutes, 5 — 180 minutes after the ICU admission.Results. Significant differences in plasma potassium level between the groups 60 minutes (P=0.01) and 180 minutes (P=0.04) after the initiation of drugs infusion were found. In group N, at the 2nd stage, a 7% decrease in the potassium level was observed, while in group R, it increased by 2.1% as compared with the baseline. By the end of the study, potassium level decreased by 6.9% in group N and by 6.5% in group R. The intragroup differences were significant in Group N at the 2nd (P=0.02) and 5th (P=0.01) stages. In group R, no significant differences vs the baseline were found at any stage. In all cases, the values were within the reference values. In group N, at the 2nd stage the sodium concentration increased compared with the 1st stage by 2.1% (P=0.01). In group R, at the 5th stage, a significant decrease of Cl- concentration by 2.7% (P=0.01) was observed. The acid-base status showed a trend towards mixed acidosis at the 2nd stage in both groups, with the similarly significant pH reduction by 1.3% vs the baseline, whereas at 5th stage the decrease of pH was more significant in Group N (by 1.2% vs the baseline) than in Group R (by 0.9%) (P=0.01). In group N, the phase angle value was found to decrease by 8.6% at the 2nd stage and by 6% at the 5th stage (P=0.01). In group R no significant differences in the phase angle values were found.Conclusion. The succinate-containing solution has more favorable effect on the water-electrolyte and blood acid-base balance, as well as the state of cell membranes compared with the 0.9% NaCl solution.

scholarly journals Effects of a new intravenous electrolyte solution for veterinary therapy on the electrolyte and acid-base balances of healthy horses

2016 ◽  
Vol 46 (8) ◽  
pp. 1479-1485 ◽  
Author(s):  
Priscilla Fajardo Valente Pereira ◽  
José Antonio Bessegatto ◽  
Gabriela de Castro Bregadioli ◽  
Stéfany Lia Oliveira Camilo ◽  
Nathali Adrielli Agassi de Sales ◽  
...  
Keyword(s):  
Electrolyte Solution ◽  
Fluid Therapy ◽  
Repeated Measures ◽  
Venous Blood ◽  
Isotonic Saline ◽  
Acid Base Balance ◽  
Acid Base ◽  
Before And After ◽  
Base Balance ◽  
Clinical Changes

ABSTRACT: The effects of a new intravenous electrolyte solution for veterinary therapy on electrolyte and acid-base balances of horses were evaluated, assessing the potential of the use of this solution as a rational alternative in fluid therapy. Eight healthy adult horses, including 4 males and 4 females, received two treatments in a cross-over design: isotonic saline solution (IS) and a test solution (TS) containing 145mEq of Na+, 5mEq of K+, 4mEq of Ca++, 2mEq of Mg++, 96mEq of Cl-, 60mEq of lactate, 50g of dextrose, and 4mg of cyanocobalamin per liter. Solutions were IV infused in a volume corresponding to 5% of BW, over 3 hours. Venous blood samples were taken 5 times before and after the infusion (at 0, 3, 6, 9 e 24h), for pHv, pCO2v, HCO3 -v, BEv, Na+, K+, Cl-, Ca++, Ca, P, Mg, glucose and L-lactate measurements, and AG and SID calculations. The data were analyzed through repeated measures ANOVA. The IS caused mild acidifying effect by increasing Cl- and decreasing plasma SID. In contrast, the TS induced mild and transient hypochloremia without changes in acid-base balance. Hyperglycemia was present at the end of the TS infusion and reversed 6 hours later. The horses did not exhibit any clinical changes. We concluded that TS is an option for fluid therapy in horses.

scholarly journals Comparative analysis of using balanced and normal saline solutions as an intraoperative therapy in newborns

2019 ◽  
Vol 9 (2) ◽  
pp. 41-49 ◽  
Author(s):  
Marianna M. Nasser ◽  
Yurii I. Kucherov ◽  
Yuliya V. Zhirkova
Keyword(s):  
Normal Saline ◽  
Saline Solution ◽  
Infusion Therapy ◽  
Hemodynamic Parameters ◽  
Acid Base Balance ◽  
Metabolic Disturbances ◽  
Acid Base ◽  
Group I ◽  
Base Balance ◽  
Group Ii

The purpose of the study was to compare the values of acid base balance, electrolytic and hemodynamic parameters in newborns depending on the composition of intraoperative infusion therapy. The study was done in 60 newborns who were given Staerofundin ISO basic infusion (10 ml/kg/hour) in group I (n=31) and normal saline solution in group II (n=29) during a surgery.Results: following the surgery, no differences in pH values were observed between the groups, moderate metabolic disturbances were found. In Group II, levels of bicarbonates decreased from 22.2 to 20.5 (р=0.047). By the end of the surgery, normal electrolyte composition was found more frequently in group I (29%) as compared to group II (20%). Hypopotassemia (34.5% and 22.6%), hyperpotassemia (44.8% and 25.8%) and hyperchloremia (63% and 51.7%) were found more frequently in group II as compared to group I, respectively. To achieve the target level of blood pressure, the bolus was injected to 29% (n=9) of children from group I and 17.2% (n=5) of children from group II. Adrenergic agonists were used in 42% of children from group I and 27.6% of children from group II (р=0,038). There were no differences between the cumulative doses.Conclusion. Sterofundin and normal saline solution demonstrated equivalent values of effectiveness and produced similar effect on the values of acid base balance, electrolytic and hemodynamic parameters during the intraoperative period in newborns.

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