The role of diffusion tensor imaging in assessing the microstructural integrity of white matter in spinal cord concussions

ObjectiveTo examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine.MethodsInterictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library.ResultsInterictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01).ConclusionWe report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.

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Altered white matter microstructural integrity revealed by voxel-wise analysis of diffusion tensor imaging in welders with manganese exposure

NeuroToxicology ◽

10.1016/j.neuro.2010.11.004 ◽

2011 ◽

Vol 32 (1) ◽

pp. 100-109 ◽

Cited By ~ 30

Author(s):

Yangho Kim ◽

Kyoung Sook Jeong ◽

Hui-Jin Song ◽

Jae-Jun Lee ◽

Jee-Hye Seo ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

White Matter ◽

Diffusion Tensor ◽

Manganese Exposure ◽

Microstructural Integrity

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Identification of Severities of Spinal Cord Injury during Acute Phase in Rats by Diffusion Tensor Imaging

10.21203/rs.3.rs-17760/v1 ◽

2020 ◽

Author(s):

Beike Chen ◽

Qiang Tan ◽

Weikang Zhao ◽

Qiming Yang ◽

Hongyan Zhang ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Diffusion Tensor Imaging ◽

White Matter ◽

Diffusion Tensor ◽

Motor Evoked Potentials ◽

Ex Vivo ◽

Female Rats ◽

Aneurysm Clip ◽

Cord Injury

Abstract Background: Diffusion tensor imaging (DTI) was an effective method to identify subtle changes to normal‐appearing white matter (WM). Here we analyzed the DTI data with other examinations, including motor evoked potentials (MEPs), histopathological images, and behavioral results, to reflect the lesion development in different degrees of spinal cord injury (SCI) in acute and subacute stage. Method: Except for 2 Sprague -Dawley rats died from anesthesia accident, the rest 42 female rats were randomized into 3 groups: control (n=6), moderate group (n=18), and severe group (n=18). Moderate (a 50-g aneurysm clip with 0.4-mm thickness spacer) or severe (a 50-g aneurysm clip with no spacer) contusion SCI at T8 vertebrae were induced. Then the electrophysiological assessments via MEPs, behavioral deterioration via the Basso, Beattie, and Bresnaha (BBB) scores, DTI data, and histopathology examination were analyzed. Results: In this study, we found that the damage of WM myelin, MEPs amplitude, BBB scores and the decreases in values of fractional anisotropy (FA) and axial diffusivity (AD) were more obvious in the severe injury group than that of the moderate group. Additionally, the FA and AD values could identify the extent of SCI in subacute and early acute SCI respectively, reﬂected in the robust correlations with MEPs and BBB scores. While the values of radial diffusivity (RD) showed no significant changes. Conclusions: Our data confirmed that DTI was a valuable in ex vivo imaging tool to identify damaged white matter tracts after graded SCI in rat, which may provide useful information for the early identification of the severity of SCI.

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Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis

Neurology ◽

10.1212/wnl.0000000000009363 ◽

2020 ◽

Vol 94 (18) ◽

pp. e1876-e1884 ◽

Cited By ~ 2

Author(s):

Abhishek Lenka ◽

Madhura Ingalhalikar ◽

Apurva Shah ◽

Jitender Saini ◽

Shyam Sundar Arumugham ◽

...

Keyword(s):

White Matter ◽

Parkinson Disease ◽

Diffusion Tensor ◽

Cross Sectional Study ◽

Cross Sectional ◽

Inferior Longitudinal Fasciculus ◽

Microstructural Integrity ◽

Tesla Scanner ◽

Diffusion Tensor Imaging Dti

ObjectiveThe objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI).MethodsThis cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients.ResultsThe severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract.ConclusionThis study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research.

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